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Hypertension 3.1 X more likely in males with poor CPY24A1 gene (but 2.5 X less likely for females) – May 2019

Sex-specific role of CYP24A1 rs2762939 in the risk of essential hypertension based on the serum vitamin D and total renin concentrations

Genomics, 16 May 2019, https://doi.org/10.1016/j.ygeno.2019.05.013
lVarsha Varakanthama Kiranmayee Alea Ashok Kumar Kurakula Sailoob Balakrishna Nagallac Dinesh Kumar Bharatraja


CYP24A1 normally breaks down excess Vitamin D in the body
CYP24A1 mutation can allow the accumulation of Vitamin D in the body
Excess Vitamin D can result in Calcium problems if Magnesium or water are not increased
   Note: A Vit D test will not detect this problem

Genetics category listing contains the following

262 articles in the Genetics category

see also

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki as of early 2019
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, and by 2017 was speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells rather than blood was feasible (2017 personal communication)
  •    Commercially available 2019
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Search VitaminDWiki for CYP24A1 1150 items as of May 2019


  • Risk of essential hypertension was found to be sex-dependent in the carriers of CC genotype of CYP24A1 rs2762939.
  • In the CC carriers of CYP24A1 rs2762939, females demonstrated a protective role whereas males had higher risk in the genetic predisposition to EH.
  • The levels of 25-hydroxy Vitamin D and total renin concentrations may explain this contrasting risk posed by the CYP24A1 rs2762939 CC variant.

CYP24A1, Vitamin D 24-hydroxylase catabolizes 25-hydroxyvitamin D (25(OH)D) and 1,25-dihydroxyvitamin D to 24-hydroxylated vitamin D products. It is widely known that low Vitamin D can lead to increased renal renin and angiotensin II production, consequently elevating blood pressure or development of essential hypertension (EH). We have conducted an investigation on hypertensives and controls to evaluate the association of the gene variant, CYP24A1 rs2762939 and 25(OH)D in an Indian population with EH. On gender-based stratification, with multivariate logistic analysis after adjustment for covariates, the CYP24A1 rs2762939 CC variant showed a higher risk of EH in males (aOR = 3.141, CI 1.164–8.478, P = .024) while females illustrated an inverse association with EH (aOR = 0.398, CI 0.172–0.092, P = .031). The 25(OH)D levels among the three genotypes of hypertensives substantiate these results. Our results clearly suggest that gender, CYP24A1 rs2762939, and Vitamin D status may play a significant role in disease susceptibility towards EH in Indian population.

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