Get Multiple Sclerosis while younger if have a poor CYP24A1 vitamin D gene – May 2023

The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients
VitaminDWiki – CYP24A1 contains
VitaminDWiki – Overview MS and vitamin D contains
VitaminDWiki - 21 studies in both categories MS and Genetics (general)
VitaminDWiki - 11 studies in both categories MS and VDR Gene
Multiple Sclerosis has been increasing at younger ages

The CYP24A1 gene variant rs2762943 is associated with low serum 1,25-dihydroxyvitamin D levels in multiple sclerosis patients

Eur J Neurol . 2023 May 14. doi: 10.1111/ene.15866 $14 paywall
Sunny Malhotra # 1, Luciana Midaglia # 1, Omar Chuquisana 2, Nikolaos A Patsopoulos 3 4 5, Roser Ferrer 6, Marina Giralt 6, Nicolas Fissolo 1, Elia Gil-Varea 1, Juan Carlos Triviño 7, Jan D Lünemann 2, Xavier Montalban 1, Manuel Comabella 1

Background: Vitamin D is considered to play a role in multiple sclerosis (MS) etiopathogenesis. We recently identified a polymorphism in the CYP24A1 gene, rs2762943, that was associated with an increased MS risk. CYP24A1 encodes a protein involved in the catabolism of the active form of vitamin D. We investigated the immunological effects of carrying the rs2762943 risk allele, and its role as genetic modifier.

Methods: Serum levels of 25-hydroxyvitamin D (25OHD) and 1,25-dihydroxyvitamin D (1,25(OH)2 D) were measured in a cohort of 167 MS patients. In a subgroup of patients, expression levels of MHC class II and co-stimulatory molecules were determined by flow cytometry, and serum levels of proinflammatory (IFNG, GM-CSF, CXCL13) and anti-inflammatory (IL-10) cytokines and neurofilament light chain were measured by single-molecule array assays. The effect of the rs2762943 polymorphism on disease activity and disability measures was evaluated in 340 MS patients.

Results: Compared to non-carriers, carriers of the rs2762943 risk allele were characterized by reduced levels of 1,25(OH)2 D (p=0.0001), and elevated levels of IFNG (p=0.03) and GM-CSF (p=0.008), whereas no significant differences were observed for the other markers. The presence of the rs2762943 risk allele had no significant impact on disease activity and disability outcomes during follow-up. However, risk allele carriers were younger at disease onset (p=0.04).

Conclusions: These findings suggest that the CYP24A1 rs2762943 polymorphism plays a more important role on MS susceptibility than on disease prognosis, and is associated with lower 1,25(OH)2 D levels and heightened pro-inflammatory environment in MS patients.

VitaminDWiki – CYP24A1 contains

Proper activation	makes sure that Vitamin D does not accumulate in the body
Too much activation	Less vitamin D actually gets to cells, also poor response to Vitamin D
Too little activation	Vitamin D accumulates to toxic levels ( <1 in 10,000 people)

Blood test does not show when a poor CYP24A1 gene stops Vitamin D from getting to cells
Click here for more information
Several Cancers and health problems appear to protect themselves by changing CYP24A1 activation

VitaminDWiki – Overview MS and vitamin D contains

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Fact: Low Vitamin D results in higher risk of getting MS
Increase latitude leads to decreased Vitamin D, which leads to increased risk of MS

There is less of an effect recently - air conditioning now allows people to stay indoors

Dark skinned people are far more likely to get MS (dark skin people typically have low vitamin D)
Elderly (who typically have low vitamin D) are more likely to get MS
Is there increased risk in people who already have diseases associated with low vitamin D - TB, for example ? ? ?
Women typically have 3X increased MS risk then men (note: women typically have 20% lower levels of vitamin D than men)
Exception: women in very sunny climates and dark-skinned women have the same MS risk as men
Obese are 60% more likely to get MS
Multiple Sclerosis 42X more likely if light brown skin and smoke (both associated with low vitamin D) – July 2020
MS recurrence is much higher in spring - the lowest time of the year for vitamin D
increase in clouds/rainfall (which reduces available Vitamin D) is associated with increased risk of MS (Scotland, Western Washington)
MS incidence has increased 70% in a decade while the incidence of vitamin D deficiency doubled
Less MS in those with outdoor occupations PDF file, not a web page
Fact: MS uses up Vitamin D
Fact: Lower vitamin D (due to MS using up Vitamin D while fighting the disease) results in many other health problems (such as broken bones), so depleted vitamin D levels must be restored.
Fact: Increasing levels of Vitamin D is associated with lower MS risk, as well as lower risk of many other diseases
Fact: Vitamin D looks so promising for preventing and treating MS that there were 25 INTERVENTION clinical trials as of Feb 2014
Fact: Vitamin D reduced the MS relapse rate far better than Fingolimod which is now used for that purpose.
- Note: Fingolimod costs $25,000/year while vitamin D, which works better and has no site effects is 1000 times less expensive.
Fact: 98% of the genes affected by Interferon are also affected by Vitamin D
- Note: 1 week of Interferon = $4,700, 1 week of vitamin D 10,000X lower cost
Fact: MS Doctors in Brazil recommending 40-100 ng/mL of Vitamin D
Fact: Many MS forums are recommending vitamin D to treat MS, with some taking 5,000 to 10,000 IU daily
Observation: Risk of going from pre-MS to MS reduced 68 percent with 7100 IU vitamin D – RCT Dec 2012
- This is an observation instead of a fact - it has not yet been confirmed.
Fact: VERY LARGE doses of vitamin D have CURED 2,000 people of MS in Brazil
Controversy: UVB fron sunlight or UVB bulb may be BETTER than Vitamin D for reducing the risk of getting MS
Hypothesis: In addition to Vitamin D there are many other photoproducts produced by UVB that may promote health.