Intraocular Calcidiol: Uncovering a role for vitamin D in the eye.
J Steroid Biochem Mol Biol. 2019 Nov 14:105536. doi: 10.1016/j.jsbmb.2019.105536.
Vision category starts with:
- 18 Myopia studies in VitaminDWiki as of Sept 2022
- An ocular disease can be associated with low vitamin D and 1 of 5 poor vitamin D genes – June 2022
- Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 2019
- Vitamin D treats and prevents a variety of eye problems (need 70 ng) – June 2018
- Age-Related Macular Degeneration - many studies
- Vitamin D and Myopia, AMD, Diabetic Retinopathy, Uveitis, Glaucoma, VDR etc. – May 2015
- Tears often have 25 % higher levels of vitamin D than does blood
- Cataracts prevented and perhaps treated by Vitamin D - 2015
- All people with Cataracts had low vitamin D levels – April 2019
- Vitamin D and Age-Related Macular Degeneration (and 2 AMD meta-analyses) – Oct 2017
- Diabetic Retinopathy associated with low Vitamin D - many studies
- 7+ studies of Glaucoma and Vitamin D
CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
CYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
53 items in CYP27B1 category 313 articles in the Genetics 470 articles in Vitamin D Receptor 169 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
Vitamin D blood test misses CYP27B1 and other genes
Note: the Vitamin D levels in the abstract appear to be in error
Typical Vitamin D levels in blood are 50X to 500X larger Download the PDF from sci-hub via VitaminDWiki
Rullo J1, Pennimpede T2, Far PM3, Strube YN3, Irrcher I3, Urton T3, Bona M3, Gonder T3, Campbell R3, Ten Hove M3, Sharma S3, Farmer J4, Petkovich M5.
1 Queen's University, Department of Ophthalmology, Kingston, Ontario, Canada. jrullo at qmed.ca
2 Queen's University, Department of Laboratory and Molecular Pathology, Kingston, Ontario, Canada.
3 Queen's University, Department of Ophthalmology, Kingston, Ontario, Canada.
4 Queen's University, Department of Ophthalmology, Kingston, Ontario, Canada; +Dept of Laboratory and Molecular Pathology
5 Queen's University, Department of Biomedical and Molecular Sciences, Kingston, Ontario, Canada.Vitamin D has emerged as a potentially important molecule in ophthalmology. To date, all ophthalmic data pertaining to vitamin D has been restricted primarily to tear and serum analysis in human patients. Considering the isolated nature of the eye, we sought to determine the presence of intraocular vitamin D in ocular disease.
METHODS:
25-hydroxyvitamin D3 (25(OH)D3) concentrations were measured in the eye and blood of 120 participants undergoing ophthalmic procedures. Ocular localization of the 1,25-dihydroxyvitamin D3-generating (CYP27B1) and deactivating (CYP24A1) hydroxylases was performed by immunohistochemistry. Gene expression of CYP27B1, CYP24A1 and VEGF-A was measured in eyes from patients with and without disease.RESULTS:
25(OH)D3 was quantified in 112 ocular samples. In 40 cataract patient samples, the average 25(OH)D3 concentration was 0.057 ng/mL, compared to 72 retinal disease patient samples, average of 0.502 ng/mL (p < 0.001).
Intraocular 25(OH)D3 did not correlate with serum levels of 25(OH)D3.
There was no difference between the level of 25(OH)D3 measured in the aqueous and vitreous humour.
The vitamin D-specific CYPs 27B1 and 24A1, strongly localized to- complementary regions of the ciliary body,
- retinal pigment epithelium and
- neural retina.
Gene expression analysis confirmed retinal CYP27B1 correlated strongly with VEGF-A in eyes from diabetic patients (r = 0.92, p < 0.001).
CONCLUSIONS:
Our data confirms that vitamin D is present in the humours of the human eye and that local synthesis/degradation is possible via the ocular CYP27B1 and CYP24A1. This argues for a functional role for local vitamin D production and signaling in the eye and suggests that vitamin D may be an important intraocular mediator in disease pathogenesis.Eye vitamin D may not be associated with blood VitD, but is associated with CYP27B1 and CYP24A1 – Nov 20192253 visitors, last modified 07 Jul, 2020, This page is in the following categories (# of items in each category)