GC Gene Polymorphisms and Vitamin D-Binding Protein Levels Are Related to the Risk of Generalized Aggressive Periodontitis
Int J Endocrinol. 2016; 2016: 5141089. online 2016 Nov 28. doi: 10.1155/2016/5141089
PMCID: PMC5149651
Wenli Song, 1 Xian'e Wang, 1 Yu Tian, 2 Xin Zhang, 3 Ruifang Lu, 1 and Huanxin Meng 1
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Objective. To explore whether GC (group-specific component) rs17467825, rs4588, and rs7041 polymorphisms are associated with generalized aggressive periodontitis.
Methods. This case-control study recruited 372 patients with generalized aggressive periodontitis (group AgP) and 133 periodontal healthy subjects (group HP). GC rs17467825, rs4588, and rs7041 genotypes and plasmatic vitamin D-binding protein (DBP) were measured. Analysis of single SNP and multiple SNPs was performed and relevance between plasmatic DBP and haplotypes was analyzed.
Results. GC rs17467825 GG genotype was statistically associated with lower risk for generalized aggressive periodontitis under the recessive model (OR = 0.52, 95% CI: 0.30–0.92, p = 0.028). GC rs17467825 and rs4588 had strong linkage disequilibrium with r 2 ≥ 0.8 and D′ ≥ 0.8. Haplotype (GC rs17467825, rs4588)
GC was associated with the less risk for generalized aggressive periodontitis (OR = 0.29, 95% CI: 0.09–0.96, p = 0.043). In group AgP, individuals with combined genotype (GC rs17467825, rs4588) AG+CA had significantly lower plasmatic DBP level than those with the other two combined genotypes (AG+CA versus AA+CC p = 0.007; AG+CA versus GG+AA p = 0.026).
Conclusions. GC rs17467825 genotype GG and haplotype (GC rs17467825, rs4588) GC are associated with generalized aggressive periodontitis. The association may be acquired through regulating DBP levels. The functions of GC gene and DBP in inflammatory disease need to be further studied.
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- “Periodontitis is primarily a chronic infectious disease. With its incidence as high as 47%–68.97%, it is the main cause of tooth loss in adults “
- “It not only affects oral health, function, and aesthetics, but also has strong association with endocrine disturbance (e.g., diabetes mellitus, obesity, and osteoporosis) and cardiovascular disease”
Note by VitaminDWiki: All of these disturbances are associated with low Vitamin D and/or Vitamin D genes - “Previous studies of our group showed that DBP level was significantly elevated in the plasma of patients with generalized aggressive periodontitis than that in healthy controls. It indicated that DBP was closely associated with generalized aggressive periodontitis”