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Vitamin D appears to keep telomeres long (longer life) – Jan 2021

The Relationship Between Vitamin D and Telomere/Telomerase: A Comprehensive Review

J Frailty Aging. 2021;10(1):2-9. doi: 10.14283/jfa.2020.33.
M Zarei 1, M Zarezadeh, F Hamedi Kalajahi, M H Javanbakht

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A portion of the table in the study
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Telomeres are repetitive nucleotide sequences that together with the associated sheltrin complex protect the ends of chromosomes and maintain genomic stability. Evidences from various organisms suggests that several factors influence telomere length regulation, such as telomere binding proteins, telomere capping proteins, telomerase, and DNA replication enzymes. Recent studies suggest that micronutrients, such as vitamin D, folate and vitamin B12, are involved in telomere biology and cellular aging.
In particular, vitamin D is important for a range of vital cellular processes including cellular differentiation, proliferation and apoptosis. As a result of the multiple functions of vitamin D it has been speculated that vitamin D might play a role in telomere biology and genomic stability. In this study, our main goal is investigating the relationship between telomerase enzyme and vitamin D. Findings of this study suggest that higher vitamin D concentrations, which are easily modifiable through nutritional supplementation, are associated with longer LTL, which underscores the potentially beneficial effects of this hormone on aging and age-related diseases.
Vitamin D may reduce telomere shortening through anti-inflammatory and anti-cell proliferation mechanisms. Significant Low levels of telomerase activity create short telomeres, which in turn signal exit from the cell cycle resulting in cell senescence and apoptosis.
In follow-up examination, the patients who remained vitamin D deficient tended to have shorter telomeres than those patients whose 25-hydroxyvitamin D levels were depleted.
Increasing 25-hydroxyvitamin D levels in patients with SLE may be beneficial in maintaining telomere length and preventing cellular aging. Moreover, anti-telomere antibody levels may be a promising biomarker of SLE status and disease activity.


Created by admin. Last Modification: Friday December 18, 2020 19:32:59 GMT-0000 by admin. (Version 5)

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ID Name Comment Uploaded Size Downloads
14736 Telemere Vitamin D studies.jpg admin 18 Dec, 2020 19:03 60.23 Kb 87
14735 Telemeres and Vitamin D sci-hub.pdf PDF 2021 admin 18 Dec, 2020 19:02 564.16 Kb 36
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