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Type II diabetes 2 X more likely if poor Vitamin D Gene (CYP27B1) – Oct 2019

J Diabetes Res. 2019 Sep 8;2019:8289741. doi: 10.1155/2019/8289741. eCollection 2019.

VitaminDWiki

Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 429 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)
    Image

23 items in CYP27B1 category

Genetics has the following chart

Vitamin D blood test misses CYP27B1
Blood Test Misses a lot (VDW 3439)

 Download the PDF from VitaminDWiki
Image

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Hu Z#1,2, Tao S#1, Liu H1, Pan G1, Li B1,3, Zhang Z1,3.
1 Dept. of Occupational and Environmental Health, School of Public Health, Medical College of Soochow University, Suzhou, China.
2 Lishui Center for Disease Control and Prevention, Lishui, China.
3 Dept. of Nutrition and Food Hygiene, School of Public Health, Medical College of Soochow University, Suzhou, China.

OBJECTIVE:
To investigate the effect of single nucleotide polymorphisms (SNPs) of the key genes in vitamin D metabolic pathway on the serum 25(OH)D level after long-term vitamin D3 supplementation and provide a theoretical basis for rational vitamin D3 supplementation in diabetic patients with different genetic backgrounds.

METHODS:
Patients with type 2 diabetes (T2DM) who met the inclusive criteria were given 800 IU of vitamin D3 daily for 30 consecutive months. Serum 25(OH)D levels was measured at enrollment and every 6 months after enrollment. The average value of four-time measurements represented individual serum 25(OH)D level during vitamin D3 supplementation. Multiplex TaqMan genotyping was used to determine the distribution of eight candidate SNPs in genes of DHCR7, CYP2R1, CYP27B1, CYP24A1, and VDR, which are key genes in the vitamin D metabolic pathway, in diabetic patients.

RESULTS:
At baseline, the average serum 25(OH)D level was 22.71 ± 6.87 ng/mL, and 17.9% of patients had a ≥30 ng/mL level. During supplementation, the level of 25(OH)D increased significantly at each time point, and the average 25(OH)D level increased to 30.61 ± 5.04 ng/mL; however, there were 44.6% of patients whose serum 25(OH)D levels were still below 30 ng/mL. In the patients with CYP27B1 (rs10877012) G/T genotype, 71.79% achieved sufficient level of 25(OH)D, which was significantly higher than the other two genotypes (P < 0.05). Compared with those with T/T genotype, the RR of the patients with rs10877012 for <30 ng/mL level was 0.544 (95% CI: 0.291-0.917), and the RR after adjusting age and outdoor activity was 0.560 (95% CI: 0.292-0.970).

CONCLUSION:
The serum 25(OH)D level in patients with diabetes mellitus after long-term vitamin D3 supplementation is associated with CYP27B1 polymorphism. Patients with rs10877012 G/T allele have a better response to vitamin D3 supplementation.

Created by admin. Last Modification: Monday October 7, 2019 15:01:05 GMT-0000 by admin. (Version 7)

Attached files

ID Name Comment Uploaded Size Downloads
12736 Diabetes genes.jpg admin 07 Oct, 2019 10:43 25.24 Kb 7
12735 Diabetes CYP27B1.jpg admin 07 Oct, 2019 10:43 30.89 Kb 7
12734 Diabetes CYP27B1.pdf PDF 2019 admin 07 Oct, 2019 10:42 1.61 Mb 10
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