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Lung cancer – reduced deaths if have a good vitamin D gene (CYP27B1) – Feb 2015

Genetic polymorphisms in the vitamin D pathway in relation to lung cancer risk and survival.

Oncotarget. 2015 Feb 10;6(4):2573-82.
Kong J1,2,3, Xu F1, Qu J1, Wang Y1, Gao M1, Yu H4, Qian B1,3.
1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China.
2Department of Cancer Epigenetics Laboratory, First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
3Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Public Health, Shanghai Jiao Tong U. School of Medicine, Shanghai, China.
4Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.

Studies have suggested that vitamin D may have protective effects against cancer development or tumor progression. To search for additional evidence, we investigated the role of genetic polymorphisms involved in the vitamin D pathway in non-small cell lung cancer (NSCLC). We evaluated common genetic polymorphisms associated with the vitamin D pathway in relation to NSCLC in a case-control study of 603 newly diagnosed NSCLC patients and 661 matched healthy controls. Seven single nucleotide polymorphisms (SNPs) were genotyped, the expression of CYP27B1 and CYP24A1 were measured in 153 tumor samples and their associations with genotypes and patient survival were also analyzed. In the case-control comparison, we found SNP rs3782130 (CYP27B1), rs7041 (GC), rs6068816 and rs4809957 (CYP24A1) associated with NSCLC risk. The risk of NSCLC was increased with the number of risk alleles. CYP27B1 and CYP24A1 expression were significantly different between tumor and normal tissues in NSCLC. High CYP27B1 expression was associated with better overall survival, and the expression was different by the rs3782130 genotype. The study suggests that some genetic polymorphisms involved in the vitamin D pathway may associate with NSCLC risk, and one of the polymorphisms (rs3782130) may affect gene expression and patient survival.

PMID: 25544771
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Notes from the web

About 85% to 90% of lung cancers diagnosis are non-small cell lung cancer (NSCLC)
NSCLCs are relatively insensitive to chemotherapy
Lung cancer in never-smokers is almost universally NSCLC

From Wikipedia

Lung Cancer summary by VitaminDWi

Lung Cancer appears to be prevented/survived if

  1. Live at high altitude
  2. Have a very high level of Vitamin D
    Note: Vitamin D test does NOT notice the effect of the CYP27B1 - which is downstream from the test
    Note: Can increase Vitamin D level in cells (without Kidney or CYP27B1)
       by increasing Magnesium, Omega-3, Resveratrol
  3. Have low level of Vitamin A which blocks Vitamin D

See also VitaminDWiki

Genetics category listing contains the following

248 articles in the Genetics category

see also 311 articles in Vitamin D Receptor, 116 articles in Vitamin D Binding Protein

Vitamin D blood test misses a lot
Blood Test Misses a lot (VDW 3439)

  • Snapshot of the literature by VitaminDWiki - (subject to many future developments)
  • Vitamin D from coming from tissues (vs blood) was speculated to be 50% in 2014, andi in 2017 is speculated to be 90%
  • Note: Good results from a blood test (> 40 ng) does not mean that a good amount of Vitamin D actually gets to cells
  • A Vitamin D test in cells appears feasible (personal communication)
    However test results would vary in each tissue due to multiple genes
  • Good clues that Vitamin D is being restricted from getting to the cells
    1) A vitamin D-related health problem runs in the family
       especially if it is one of 51+ diseases related to Vitamin D Receptor
    2) Slightly increasing Vitamin D show benefits (even if conventional Vitamin D test shows an increase)
    3) Vitamin D Receptor test (<$30) scores are difficult to understand in 2016
        easier to understand the VDR 23andMe test results analyzed by FoundMyFitness in 2018
    4) Back Pain
        probably want at least 2 clues before taking adding vitamin D, Omega-3, Magnesium, Resveratrol, etc
          The founder of VitaminDWiki took action with clues #3&4

Attached files

ID Name Comment Uploaded Size Downloads
6347 CP27B1 lung.jpg admin 16 Jan, 2016 15:20 19.54 Kb 757
6346 Pie_chart_of_lung_cancers.svg admin 16 Jan, 2016 15:18 18.19 Kb 210
6345 Lung cancer genes.pdf PDF 2015 admin 16 Jan, 2016 15:17 1.22 Mb 265
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