Obesity represses CYP2R1 , the vitamin D 25‐hydroxylase, in the liver and extrahepatic tissues
Journal of Bone and Mineral Research PLUS https://doi.org/10.1002/jbm4.10397
Mahmoud‐Sobhy Elkhwanky Outi Kummu Terhi T. Piltonen Johanna Laru Laure Morin‐Papunen Maija Mutikainen Pasi Tavi Jukka Hakkola
- For years it had been believed that obese people store vitamin D in fatty tissue.
- This study found that surgically removing fatty tissue in humans increases the activation of the CYP2R1 gene, which results in semi-activation of more Vitamin D
- This could be the reason that more vitamin D appears to increase after weight loss, rather than the theory that fatty tissue stores the Vitamin D
- But, fat surgery also decreases the amount of semi-activated VItamin D in the blood which is activated (CYP27B1)
Overview Obesity and Vitamin D contains the following summary
- FACT: People who are obese have less vitamin D in their blood
- FACT: Obese need a higher dose of vitamin D to get to the same level of vit D
- FACT: When obese people lose weight the vitamin D level in their blood increases
- FACT: Adding Calcium, perhaps in the form of fortified milk, often reduces weight
- FACT: 168 trials for vitamin D intervention of obesity as of Dec 2021
- FACT: Less weight gain by senior women with > 30 ng of vitamin D
- FACT: Dieters lost additional 5 lbs if vitamin D supplementation got them above 32 ng - RCT
- FACT: Obese lost 3X more weight by adding $10 of Vitamin D
- FACT: Those with darker skins were more likely to be obese Sept 2014
- OBSERVATION: Low Vitamin D while pregnancy ==> more obese child and adult
- OBSERVATION: Many mammals had evolved to add fat and vitamin D in the autumn
- and lose both in the Spring - unfortunately humans have forgotten to lose the fat in the Spring
- SPECULATION: Low vitamin D might be one of the causes of obesity – several studies
- SUGGESTION: Probably need more than 4,000 IU to lose weight if very low on vitamin D due to
risk factors such as overweight, age, dark skin, live far from equator,shut-in, etc. - Obesity category has
442 items See also: Weight loss and Vitamin D - many studies Child Obesity and Vitamin D - many studies Obesity, Virus, and Vitamin D - many studies
Obese need more Vitamin D- Normal weight Obese (50 ng = 125 nanomole)
- Normal weight Obese (50 ng = 125 nanomole)
CYP27B1 category listing contains the following
The CYP27B1 gene activates Vitamin D in the Kidney, Skin, Lungs, Brain, Eyes Breasts etc.
Poor CYP27B1 is assocated with COVID, Miscarriage, Lupus, Alz, Parkinson, MSA, RicketsCYtochrome P450 family 27 subfamily B member 1 = 25-Hydroxyvitamin D3 1-alpha-hydroxylase
63 items in CYP27B1 category 343 articles in the Genetics 530 articles in Vitamin D Receptor 178 articles in Vitamin D Binding Protein - CYP27B1 and other genes are less activated in seniors
- CYP27B causes many health problems – March 2020
- Every Parkinson’s brain had a poor CYP27B1 gene
What can be done if have a poor CYP27B1
- Larger doses of Vitamin D
- More Bio-available: Gut-friendly form, Topical form, taken with fatty meal, taken with evening meal
- Additional sources: UV
- Increase Vitamin D metabolism: additional Magnesium, Omega-3
- All cytochrome P450 enzymes require Mg++ as a cofactor
- Increase the amount of Vitamin D in the blood that gets to cells: increase activation of VDR
Vitamin D blood test misses CYP27B1 and other genes
Items in both of the categories of Genetics AND Obesity
- Obesity is associated with 1 to 5 poor vitamin D genes (childhood obesity in the case) – July 2024
- Obese children have poor vitamin D genes (CYP27A1, CYP2R1, CYP27B1) – March 2024
- Obese children had less gene methylation (gene not work as well) – March 2024
- Response to Vitamin D varies with genes (3,000 IU, weight loss in this RCT) – March 2022
- High-fat diet reduces CYP2R1 gene needed to make semi-activated vitamin D (mice) – Aug 2021
- Hypothesis: Obesity reduces Vitamin D production by repressing CYP2R1 gene in liver and fat tissue – July 2020
- Increased risk of weight gain when gene restricts Vitamin D getting to tissues (CYP24A1 in this case) – Nov 2019
- Obesity associated with poor Vitamin D genes (VDR in this study) – Jan 2018
- Gut genes related to important disease changed in Obese with 2,000 IU for 12 weeks – May 2019
- Obesity cut semi-activation of Vitamin D in half (mice) – Jan 2019
- Obesity might be related to Vitamin D genes – July 2018
- Vitamin D restricted in getting to cells by genes, obesity, etc – Jan 2017
- Multiple Sclerosis and obesity share some gene problems (as well as low vitamin D) – June 2016
- Vitamin D may block the obesity gene (FTO) – Jan 2014
- Vitamin D roles in obesity: genetics and cell signaling – June 2013
- Obese have 50 percent less of two enzymes in fatty tissue to process vitamin D – May 2013
- No apparent genetic association between vitamin D and obesity – Feb 2013
- Genes indicate that Obesity causes vitamin D deficiency – Feb 2013
Download the PDF from VitaminDWiki
Low plasma level of 25‐hydroxyvitamin D (25‐OH‐D), namely vitamin D deficiency, is associated with obesity and weight loss improves 25‐OH‐D status. However, the mechanism behind obesity‐induced vitamin D deficiency remains unclear. Here, we report that obesity suppresses the expression of cytochrome P450 (CYP) 2R1, the main vitamin D 25‐hydroxylase, in both mice and humans.
In humans, weight loss induced by gastric bypass surgery increased the expression of CYP2R1 in the subcutaneous adipose tissue suggesting recovery after the obesity‐induced suppression. At the same time, CYP27B1, the vitamin D 1α‐hydroxylase, was repressed by the weight loss. In a mouse (C57BL/6N) model of diet‐induced obesity, the plasma 25‐OH‐D was decreased. In accordance, the CYP2R1 expression was strongly repressed in the liver. Moreover, obesity repressed the expression of CYP2R1 in several extrahepatic tissues e.g. the kidney, brown adipose tissue and testis but not in the white adipose tissue. Obesity had a similar effect in both male and female mice. In mice, obesity repressed expression of the vitamin D receptor in brown adipose tissue. Obesity also upregulated the expression of the vitamin D receptor and CYP24A1 in the subcutaneous adipose tissue of a subset of mice; however, no effect was observed in the human subcutaneous adipose tissue.
In summary, we show that obesity affects CYP2R1 expression both in the mouse and human tissues. We suggest that in mouse the CYP2R1 repression in the liver plays an important role in obesity‐induced vitamin D deficiency.
Currently, it is unclear whether the CYP2R1 downregulation in extrahepatic tissues could contribute to the obesity‐induced low plasma 25‐OH‐D, however, this phenomenon may affect at least the local 25‐OH‐D concentrations.Hypothesis: Obesity reduces Vitamin D production by repressing CYP2R1 gene in liver and fat tissue – July 2020(Cached) Printer Friendly Follow this page for updates7098 visitors, last modified 21 Jul, 2020, This page is in the following categories (# of items in each category)Attached files
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