The effects of vitamin D3 supplementation on some metabolic and inflammatory markers in diabetic nephropathy patients with marginal status of vitamin D: A randomized double blind placebo controlled clinical trial
Diabetes & Metabolic Syndrome: Clinical Research & Reviews, Vol13, Issue 1, Jan–Feb 2019, Pages 278-283, https://doi.org/10.1016/j.dsx.2018.09.013
Note: The trial lasted only 8 weeks
Can anticipate even better results for trials lasting 12-24 weeks
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
413 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
which also includes Diabetic Epidemic
- Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
Chart from the web (2018?)
Kidney
- Every child with kidney problems (ideopathic nephrotic syndrome) had low vitamin D – Oct 2015
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Diabetic neuropathy reduced by injection of 600,000 IU of vitamin D – Feb 2016
- Diabetic Nephropathy – active vitamin D helps – Dec 2014
- Blacks have 4X more Kidney disease than whites – probably due to low vitamin D – March 2015
- Diabetic neuropathy least likely if have 30-40 ng of vitamin D – Oct 2015
Items in both categories Diabetes and Kidney are listed here
- Diabetic kidney problems in children last longer if low vitamin D – May 2019
- Vitamin D helps Diabetic Nephropathy kidneys – meta-analysis April 2019
- Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
- Diabetic nephropathy (Kidney problem) 1.8 X more likely if poor Vitamin D Receptor – meta-analysis July 2017
- Psoriasis is associated with kidney disease, heart problems, diabetes, etc – Nov 2015
- Diabetic Nephropathy – active vitamin D helps – Dec 2014
- Fructose reduced blood levels of active vitamin D - April 2014
- Table of outcomes for seniors vs vitamin D level
- Vitamin D decreases incidence of disease
Overview Diabetes and vitamin D contains the following summary
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on - All items in category Diabetes and Vitamin D
413 items: both Type 1 and Type 2 Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
which are just some of the vitamin D cofactors
Diabetes category starts with the following
413 items In Diabetes category see also Overview Diabetes and vitamin D Overview Metabolic Syndrome and vitamin D
Autoimmune category listing has139 items along with related searches T1 diabetes OR type1 diabetes in title 107 as of April 2018
prediabetes OR prediabetic 336 items as of Jan 2018
Search VitaminDWiki for Peripheral Neuropathy 238 items April 2018
Images from the web
Download the PDF from VitaminDWiki
Metabolic and Inflammatory parameters.
Aims
Diabetic nephropathy is known to be an independent risk factor in the progression of renal and cardiovascular disorders. Due to the association between vitamin D deficiency and diabetic nephropathy, vitamin D deficiency in the diabetic nephropathy population, this study conducted to examine the effects of Vitamin D3 on metabolic and inflammatory parameters in patients with diabetic nephropathy.Methods
This eight-week, randomized, double-blind, placebo-controlled trial was carried out on 50 diabetic nephropathy patients with marginal status of vitamin D. Participants were randomly assigned to two groups: control and intervention. Participants received a vitamin D3 (50000 IU) supplement weekly on a specific day. Fasting blood samples were collected from all patients at their entry to the study, and eight weeks after intervention.Results
Analyses showed significance differences in physical activity between the intervention and placebo groups (P = 0.018). There were no significant differences between the percentage changes of HbA1c, insulin and, inflammatory parameters such as TNF-α and IL-6 (P > 0.05), while the percentage change of FBS was significantly higher in the placebo group compared to the treatment one (P < 0.0001). Lower levels of FBS (P < 0.0001), insulin (P < 0.069), HOMA-IR (P < 0.001), TNF-α (P< 0.002) and IL-6 (P < 0.037) were found after supplementation in treatment group. However, the phosphorous and protein percentage change in urine were lower (P = 0.07) and higher (P = 0.003) between groups.Conclusions
This page was renamed on Nov 2018. There have actually been
It was found that vitamin D supplementation can be regarded as an effective way to prevent the progression of diabetic nephropathy by reducing levels of proteinuria, and inflammatory markers such as TNF-α and IL-6.652 visitors to this page since it was originally made
Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
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