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50,000 IU of Vitamin D once every 2 weeks achieved 40 ng in 3 months – RCT March 2021

Effect of Monthly and Bi-Monthly 50,000 International Units (IU) Maintenance Therapy With Vitamin D3 on Serum Level of 25-Hydroxyvitamin D in Adults: A Randomized Controlled Trial

DOI: 10.7759/cureus.13929
Mohammed A. AlAteeq, Abdulaziz AlShail, Amal AlZahrani, Osama AlNafisah, Emad Masuadi, Awad Alshahrani

VitaminDWiki

Trial compared responses to 50,000 given

every 2 weeks achieved 40 ng
every 4 weeks DECREASED by 10 ng

One 50K dose every two weeks fights

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What is an Optimal Level: 40 ng, 50 ng, 60 ng, 80 ng?

Better than Daily has the following
Non-daily (Bolus) is sometimes better - Possible reasons include:

  1. Better compliance
    • Fewer opportunities to forget
    • Fewer times to have to take a pill - for those who dislike it
  2. High concentration resulting from infrequent dosing gets past some gene and gut limitations
    • Note: Many studies have found non-daily to be better than daily
      I am unaware of a single study which has found daily to be better than non-daily - Founder of VitaminDWiki Dec 2019

 Download the PDF from VitaminDWiki

Background
Vitamin D deficiency is a prevalent condition worldwide. Identification of optimal supplementation approaches for maintaining normal vitamin D level in healthy adults is still required. It has been clearly established that sun exposure and diet do not provide the recommended daily amount of vitamin D, and that vitamin D supplementation is needed to maintain normal levels in the Saudi population. The aim of this study was to compare the efficacy of two regimens, monthly and bimonthly doses of 50,000 International Units (IU) cholecalciferol (vitamin D3), in maintaining normal serum levels of 25-hydroxyvitamin D in Saudi adults.

Methods
This study was a randomized controlled trial conducted to compare the efficacy of three regimens in maintaining a normal level of vitamin D in adult individuals. The study took place at three primary healthcare centers in King Abdul-Aziz Medical City, Riyadh, Saudi Arabia. A total of 65 participants were enrolled and randomly divided into two intervention groups and one control group. All participants were contacted by researchers and followed up at their corresponding primary health care center for two successive visits.

Results
All 65 participants completed the study. The participants were mostly females (49; 75.4%); the mean age was 42.1 years (±13.5). The difference in vitamin D levels after three months of the trial was statistically significant among the three groups. A decrease in vitamin D level was recorded in the control group and in the once monthly intake of 50,000 IU group. The bimonthly intake of 50,000 IU group maintained statistically significant vitamin D levels > 75.

Conclusion
Bimonthly vitamin D3 supplementation appears to be an efficient regimen for maintaining a normal level of 25(OH)D, regardless of the amount of vitamin D obtained from diet and sun exposure.


Created by admin. Last Modification: Sunday April 25, 2021 02:11:17 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
15493 bi-weekly 50K vitamin D - RCT.pdf PDF 2021 admin 24 Apr, 2021 19:55 280.46 Kb 19
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