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Faster growth in infants getting 1200 IU of Vitamin D – RCT July 2022


Collagen X biomarker (CXM), linear growth, and bone development in a Vitamin D intervention study in Infants

J Bone Miner Res. 2022 Jul 15. doi: 10.1002/jbmr.4650   PDF is behind paywall
Helena H Hauta-Alus 1 2 3 4, Elisa M Holmlund-Suila 1 2, Saara M Valkama 1 2, Maria Enlund-Cerullo 1 2, Jenni Rosendahl 1 2, Ryan F Coghlan 5, Sture Andersson 1, Outi Mäkitie 1 6 7

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Collagen X biomarker (CXM) is suggested to be a biomarker of linear growth velocity. However, early childhood data are limited. This study examines the relationship of CXM to the linear growth rate and bone development, including the possible modifying effects of vitamin D supplementation. We analyzed a cohort of 276 term-born children participating in the Vitamin D Intervention in Infants (VIDI) study. Infants received 10 μg/d (group-10) or 30 μg/d (group-30) vitamin D3 supplementation for the first two years of life. CXM and length were measured at 12 and 24 months of age. Tibial bone mineral content (BMC), volumetric bone mineral density (vBMD), cross-sectional area (CSA), polar-moment of inertia (PMI), and periosteal circumference (PsC) were measured using peripheral quantitative computed tomography (pQCT) at 12 and 24 months. We calculated linear growth as length velocity (cm/year) and the growth rate in length (SD unit).

The mean (SD) CXM values were 40.2 (17.4) ng/ml at 12 months and 38.1 (12.0) ng/ml at 24 months of age (p=0.12).
CXM associated with linear growth during the two years follow-up (p=0.041) but not with bone (p=0.53). Infants in group-30 in the highest tertile of CXM exhibited an accelerated mean growth rate in length compared with the intermediate tertile (mean difference (95% CI): -0.50 (-0.98, -0.01) SD unit, p=0.044) but not in the group-10 (p=0.062) at 12 months.

Linear association of CXM and growth rate until 12 months was weak, but at 24 months CXM associated with both length velocity (B for 1 increment of √CXM (95% CI): 0.32 (0.12, 0.52) cm/year, p=0.002) and growth rate in length (0.20 (0.08, 0.32) SD unit, p=0.002).

To conclude, CXM may not reliably reflect linear growth from birth to 12 months of age, but its correlation with growth velocity improves during the second year of life.


VitaminDWiki - Infant-Child category has 838 items and starts with__

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

  • Sun is great – well known for 1,000’s of years.
    US govt (1934) even said infants should be out in the sun
  • One country recommended 2,000 IU daily for decades – with no known problems
  • As with adults, infants and children can have loading doses and rarely need tests
  • Daily dose appears to be best, but monthly seems OK
  • Vitamin D is typically given to infants in the form of drops
       big difference in taste between brands
       can also use water-soluable form of vitamin D in milk, food, juice,
  • Infants have evolved to get a big boost of vitamin D immediately after birth
    Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
  • 100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
    More than 100 IU/kg is probably better

Less frequent dosing is effective (and often better than daily)

Better than Daily has the following

31 items in BETTER THAN DAILY category

Non-daily (Bolus) is better:

  1. Better compliance for everyone
    • Fewer opportunities to forget.
    • If happen to forget, just take the pill days or weeks later
    • Fewer times to have to take a pill - for those who dislike doing so
  2. Non-daily is better the ~20% who have a poor Vitamin D Receptor
    • A high concentration gradient is one of 14 ways to get past Vitamin D Receptor limitations
    • So, while 80% get no extra benefit from non-daily dosing, 20% will get an extra benefit

Obese need more vitamin D - including obese childen


Created by admin. Last Modification: Friday August 26, 2022 15:07:45 GMT-0000 by admin. (Version 12)

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18114 Growth.jpg admin 16 Jul, 2022 89.84 Kb 236