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Toggle Health Problems and D

Inflammatory Bowel Disease – proposed Vitamin D protocol – Oct 2019

Managing vitamin D deficiency in inflammatory bowel disease.

Frontline Gastroenterol. 2019 Oct;10(4):394-400. doi: 10.1136/flgastro-2018-101055. Epub 2019 Jan 7.
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Nielsen OH1 ohn at dadlnet.dk, Hansen TI1, Gubatan JM2, Jensen KB3,4, Rejnmark L5.
1 Department of Gastroenterology, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
2 Division of Gastroenterology and Hepatology, Stanford University Medical Center, Palo Alto, California, USA.
3 Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark.
4 Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Stem Cell Research, University of Copenhagen, Copenhagen, Denmark.
5 Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark.

VitaminDWiki

Even with malabsorption there are many great ways to supplement vitamin D

Overview Gut and vitamin D contains gut-friendly information

Gut-friendly, Sublingual, injection, topical, UV, sunshine

Getting Vitamin D into your body has the following chart
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Getting Vitamin D into your body also has the following

If poorly functioning gut

Bio-D-Mulsion Forte – especially made for those with poorly functioning guts, or perhaps lacking gallbladder
Sublingual – goes directly into bloodstream
Oil: 1 drop typically contains 400 IU, 1,000 IU, or 4,000 IU, typically not taste good
Topical – goes directly into bloodstream. Put oil on your skin, Use Aloe vera cream with Vitamin D, or make your own
Vaginal – goes directly into bloodstream. Prescription only?
Bio-Tech might be usefulit is also water soluble
Vitamin D sprayed inside cheeks 2X more response (poor gut) – RCT Oct 2015
    and, those people with malabsorption problems had a larger response to spray
Inject Vitamin D quarterly into muscle, into vein, or perhaps into body cavity if quickly needed
Nanoparticles could be used to increase vitamin D getting to the gut – Oct 2015
Poor guts need different forms of vitamin D has the following
Guesses of Vitamin D response if poor gut

Bio FormSpeedDuration
10Injection: Vitamin D,
or Calcidiol or Calcitriol
D - Slow
C -Fast
Long
10 Sun/UVSlowLong
10Topical
(skin patch/cream, vagina)
Slow
Fast nano
Normal
9?Inhaled (future)FastNormal
8Bio-D-Mulsion ForteNormalNormal
6Water soluble (Bio-Tech)NormalNormal
5Nanoemulsion
perhaps activates VDR
NormalNormal
4Sublingual/spray
(some goes into gut)
FastNormal
3Coconut oil basedSlowNormal
2Food (salmon etc.)SlowNormal
2Olive oil based (majority)SlowNormal

10= best bioavailable, 0 = worst, guesses have a range of +-2
Speed: Fast ~2-6 hours, Slow ~10-30 hours
Duration: Long ~3-6 months, Normal = ~2 months

Overview Gut and vitamin D has the following summary

  • Gut problems result in reduced absorption of Vitamin D, Magnesium, etc.
  • Celiac disease has a strong genetic component.
    • Most, but not all, people with celiac disease have a gene variant.
    • An adequate level vitamin D seems to decrease the probability of getting celiac disease.
    • Celiac disease causes poor absorption of nutrients such as vitamin D.
    • Bringing the blood level of vitamin D back to normal in patients with celiac disease decreases symptoms.
    • The prevalence of celiac disease, not just its diagnosis, has increased 4X in the past 30 years, similar to the increase in Vitamin D deficiency.
  • Review in Nov 2013 found that Vitamin D helped
    Many intervention clinical trials with vitamin D for Gut problems (101 trials listed as of Sept 2019)
  • All items in category gut and vitamin D 162 items

See also VitaminDWiki

The Meta-analysis of Gut and Vitamin D

 Download the PDF from VitaminDWiki

Management of inflammatory bowel disease (IBD), including ulcerative colitis and Crohn's disease, is generally cumbersome for patients and is a massive health-economic burden. In recent years, the immunomodulating effects of vitamin D have gained a huge interest in its possible pathogenic influence on the pathophysiology of IBD. Vitamin D deficiency is frequent among patients with IBD. Several clinical studies have pointed to a critical role for vitamin D in ameliorating disease outcomes. Although causation versus correlation unfortunately remains an overwhelming issue in the illusive chicken versus egg debate regarding vitamin D and IBD, here we summarise the latest knowledge of the immunological effects of vitamin D in IBD and recommend from available evidence that physicians regularly monitor serum 25(OH)D levels in patients with IBD. Moreover, we propose an algorithm for optimising vitamin D status in patients with IBD in clinical practice. Awaiting well-powered controlled clinical trials, we consider vitamin D supplementation to be an affordable and widely accessible therapeutic strategy to ameliorate IBD clinical outcomes.


Created by admin. Last Modification: Tuesday October 29, 2019 15:13:53 GMT-0000 by admin. (Version 6)

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12882 IBD Oct 2019.pdf PDF 2019 admin 29 Oct, 2019 13:34 834.95 Kb 91
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