Loading...
 
Translate Register Log In Login with facebookLogin and Register

Fibromyalgia pain with trazodone reduced by 50 percent with weekly 50,000 IU of vitamin D – RCT Nov 2014

Effect of vitamin D on widespread pain index of fibromyalgia patients

RAZI Jounal of Medical Science -Volume 21, Number 124 (10-2014) ::
Mozhdeh Zabihiyeganeh , Elnaz Khiabani, Marzieh Nojomi , Seyed Adel Jahed
Assistant Professor of Internal Medicine & Rheumatology, Firoozgar General Hospital Iran University of Medical Sciences

VitaminDWiki Summary

8 week RCT

Group Initial
pain score
Final
pain score
%
decrease
50,000 IU weekly RCT + trazodone 12.2 4.4 64%
Trazodone13.5841%

See also VitaminDWiki

Image

VitaminDWiki guess of results if they had started with a loading dose of 400,000 IU
Image


Background: Various studies have reported hypovitaminosis D in Fibromyalgia patients. In the present study, we have evaluated the effect of vitamin D supplements on widespread pain index of fibromyalgia patients.

Methods: The present study was performed from October 2012 to February 2014 in Rheumatology Clinic of Firoozgar Hospital. A total of 74 patients diagnosed as fibromyalgia according to American College of Rheumatology (ACR 2010) criteria who had hypovitaminosis D were selected. Patients were randomized to two groups. Group A received oral vitamin D 50,000 IU weekly plus trazodone 25 mg at bedtime and group B received trazodone 25 mg at bedtime only.

The patients were evaluated at baseline and 4 and 8 weeks post treatment. At each visit physical examination for tender points and 25 (OH) D level measurement were performed.
Image
Results: About 68.5% of patients with fibromyalgia had hypovitaminosis D. The mean 25(OH) D was 12.4±6.9 ng/ml (11.4±6.5 ng/ml and 13.4±7.3 ng/ml in group A and group B, respectively). There was no significant difference between the two groups at baseline. Comparison between widespread pain index (WPI) scores before and after treatment showed a significant improvement in both groups, 12.2±2.4 at baseline to 4.5±2.5 at week 8 in group A vs. 13.5±3.4 to 8±4.8 in group B. Patients receiving vitamin D showed more improvement than those receiving trazodone only, mean WPI score differences of 7.8±2.8 vs. 5.5±4 respectively, p=0.007.

Conclusion: The present study indicated that treating hypovitaminosis D may improve WPI in Fibromyalgia patients.

 Download the PDF (Persian) from VitaminDWiki.

Attached files

ID Name Comment Uploaded Size Downloads
4618 Fibro & loading dose.jpg admin 22 Nov, 2014 22:07 22.20 Kb 1834
4617 Fibro.jpg admin 22 Nov, 2014 21:48 24.31 Kb 1594
4616 Fibromyalgia - Persian.pdf PDF 2014 admin 22 Nov, 2014 21:48 883.44 Kb 727
See any problem with this page? Report it (FINALLY WORKS)