Effect of vitamin D on widespread pain index of fibromyalgia patients
RAZI Jounal of Medical Science -Volume 21, Number 124 (10-2014) ::
Mozhdeh Zabihiyeganeh , Elnaz Khiabani, Marzieh Nojomi , Seyed Adel Jahed
Assistant Professor of Internal Medicine & Rheumatology, Firoozgar General Hospital Iran University of Medical Sciences
8 week RCT
| Group | Initial pain score | Final pain score | % decrease |
| 50,000 IU weekly RCT + trazodone | 12.2 | 4.4 | 64% |
| Trazodone | 13.5 | 8 | 41% |
See also VitaminDWiki
- Fibromyalgia pain reduced with vitamin D intervention that achieved 30-48 ng – RCT Feb 2014
- Overview Pain and Vitamin D
- Proof that Vitamin D Works Fibromyalgia is #39
- Overview Fibromyalgia or Chronic Fatigue and vitamin D has the following chart
VitaminDWiki guess of results if they had started with a loading dose of 400,000 IU
Background: Various studies have reported hypovitaminosis D in Fibromyalgia patients. In the present study, we have evaluated the effect of vitamin D supplements on widespread pain index of fibromyalgia patients.
Methods: The present study was performed from October 2012 to February 2014 in Rheumatology Clinic of Firoozgar Hospital. A total of 74 patients diagnosed as fibromyalgia according to American College of Rheumatology (ACR 2010) criteria who had hypovitaminosis D were selected. Patients were randomized to two groups. Group A received oral vitamin D 50,000 IU weekly plus trazodone 25 mg at bedtime and group B received trazodone 25 mg at bedtime only.
The patients were evaluated at baseline and 4 and 8 weeks post treatment. At each visit physical examination for tender points and 25 (OH) D level measurement were performed.
Results: About 68.5% of patients with fibromyalgia had hypovitaminosis D. The mean 25(OH) D was 12.4±6.9 ng/ml (11.4±6.5 ng/ml and 13.4±7.3 ng/ml in group A and group B, respectively). There was no significant difference between the two groups at baseline. Comparison between widespread pain index (WPI) scores before and after treatment showed a significant improvement in both groups, 12.2±2.4 at baseline to 4.5±2.5 at week 8 in group A vs. 13.5±3.4 to 8±4.8 in group B. Patients receiving vitamin D showed more improvement than those receiving trazodone only, mean WPI score differences of 7.8±2.8 vs. 5.5±4 respectively, p=0.007.
Conclusion: The present study indicated that treating hypovitaminosis D may improve WPI in Fibromyalgia patients.