Toggle Health Problems and D

Diabetic inflammation reduced by Vitamin D (30,000 IU weekly) – RCT July 2020

Effect of Vitamin D Supplementation on Inflammatory Markers in Non-Obese Lebanese Patients with Type 2 Diabetes: A Randomized Controlled Trial

Nutrients 2020, 12(7), 2033; https://doi.org/10.3390/nu12072033

Better than Daily category listing has 24 items along with related searches

Items in both categories Diabetes and Inflammation are listed here:

Items in both categories Diabetes and Intervention are listed here:

 Download the PDF from VitaminDWiki

by Cynthia El Hajj 1,2,*,Stéphane Walrand 2,Mariana Helou 3 andKaissar Yammine 4

  • 1 Department of Nutrition, Faculty of Natural Sciences, Lebanese American University, Beirut 1102 2801, Lebanon
  • 2 Unité de Nutrition Humaine, France Clermont Université, Université d’Auvergne, INRA, UMR 1019, UNH, CRNH Auvergne, 63009 Clermont-Ferrand, France
  • 3 Department of Medicine, School of Medicine, Lebanese American University, Beirut 1102, Lebanon
  • 4 Department of Orthopedic Surgery, Lebanese American University School of Medecine-Rizk Hospital, Beirut, Lebanon-Center for Evidence-Based Anatomy, Sports & Orthopedic Research, Jdeideh 1102, Lebanon

Background: A low serum 25-hydroxyvitamin D (25(OH) D) concentration has been associated with a higher risk of type 2 diabetes mellitus (T2DM), especially in older people. Our aim in this randomized controlled trial was to evaluate the effect of vitamin D treatment on inflammatory markers in non-obese Lebanese patients with T2DM, living in Beirut, Lebanon.

Methods: Non-Obese patients with T2DM (n = 88), deficient/insufficient in vitamin D, were randomly assigned into one of two groups—a treatment group receiving 30,000 IU cholecalciferol/week for a period of six months, and a placebo group. Serum concentrations of TNF-α, high-sensitivity C-reactive protein (hs-CRP), and Interleukin-6 (IL-6) were the primary outcomes. A homeostatic model of insulin resistance (HOMA-IR) was assessed, in addition to serum concentrations of fasting blood glucose (FBG), HbA1C, (25(OH) D), and PTH.

Results: The vitamin D group showed higher blood levels of (25(OH) D) (p < 0.0001), and a significant reduction in hs-CRP and TNF-α concentrations (p < 0.0001) compared to placebo. The decrease perceived in IL-6 concentrations was not significant (p = 0.1). No significant changes were seen in FBG (p = 0.9) and HbA1c levels (p = 0.85).

Conclusion: Six months of vitamin D supplementation led to a decrease in some inflammatory markers in patients with T2DM. Additional studies with a larger sample and a longer period are advised in this regard. This trial was registered at ClinicalTrial.gov; Identifier number: NCT 03782805.

Created by admin. Last Modification: Thursday July 9, 2020 12:37:10 GMT-0000 by admin. (Version 5)

Attached files

ID Name Comment Uploaded Size Downloads
14008 Diabetes inflamation reduced by weekly 30,000 IU of vitamin D.pdf PDF 2020 admin 09 Jul, 2020 11:34 455.52 Kb 360