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Less morphine recall if preceded by twice a week Vitamin D (400 IU per kg in rats, human weights 80 kg) – Aug 2023

Attenuation of morphine conditioned place preference and reinstatement by vitamin D

Behav Pharmacol. 2023 Aug 15. doi: 10.1097/FBP.0000000000000747
Mahdieh Akbari 1, Houman Parsaei 2, Katayoun Sedaghat 1, Fatemeh Mousavi 1

  • 1 Research Center of Physiology, Semnan University of Medical Sciences, Semnan and.
  • 2 Department of Anatomy, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Opioid action in the brain involves the dopamine-reward system as well as non-dopamine pathways. Since vitamin D also modulates the brain's dopamine system, the question of this study was how vitamin D might affect the opioid influences on the reward system. Therefore, the objective of this study was to investigate the possible effect of vitamin D on the conditioned place preference (CPP) induced by morphine, as a valuable model of assessment of the reinforcing properties of opioids by associating the context to the rewarding properties of the addictive drugs. Male Wistar rats were randomly divided into two main groups that either received saline (morphine vehicle) or morphine (5 mg/kg, intraperitoneally) for CPP. Each of the main groups was divided into three vitamin D treatment subgroups: vitamin D vehicle and vitamin D (5 and 10 μg/kg, intraperitoneally). Vitamin D injections were started 1 week ahead of the experiment (two injections) or immediately after post-conditioning and in both cases, it was continued twice weekly throughout the CPP. Administration of vitamin D (10 μg/kg) before conditioning in CPP markedly attenuated morphine expression in the post-conditioning test. Receiving vitamin D (5 or 10 μg/kg) before or after conditioning significantly attenuated morphine reinstatement. Administration of vitamin D after opioid conditioning facilitated morphine memory extinction and attenuated morphine reinstatement. Vitamin D is probably a valuable addition to be considered as a part of the treatment for prevention or minimizing the dependency or relapse to opioids.

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16+ VitaminDWiki pages have MORPHINE or OPIOIDS or OPIATE or ADDICTION in the title

This list is automatically updated

Items found: 16
Title Modified
Opioid and alcohol use disorders increase by 10% after some Cancers (Vit D can help)- Jan 2024 19 Jan, 2024
Less morphine recall if preceded by twice a week Vitamin D (400 IU per kg in rats, human weights 80 kg) – Aug 2023 15 Aug, 2023
Opioid addiction related to low vitamin D in many ways (in both mice and men) – June 2021 13 Oct, 2022
Opioids leading cause of poisoning deaths in young children - Oct 2022 13 Oct, 2022
Opiate addiction 2.4 X more likely if vitamin D deficient before surgery – June 2020 26 Jun, 2020
Opioid addiction reduced by Omega-3 (gut inflammation in mice) – Aug 2019 15 Dec, 2019
Opiates: “It smells like doctors being bribed to sell narcotics, and that's very disturbing” – March 2018 09 May, 2018
Opioid dependency associated with vitamin D levels which are 8 % higher initially – Jan 2018 15 Jan, 2018
Off topic – CBD conflict – W.H.O. non addicting, may have medical benefits, DEA US class 1 narcotic – Dec 2017 17 Dec, 2017
Off topic: Opiate Deaths increased 5.4 X in US in just three years - Sept 2017 04 Sep, 2017
Palliative cancer benefit of 4,000 IU of Vitamin D – less opioids, infection, and CRP – Aug 2017 01 Sep, 2017
Off Topic: 4X increase in Americans taking morphine-type drugs in last decade (consider Vitamin D instead) – Aug 2014 04 Aug, 2017
Hypothesis: Drug addiction in humans can be prevented and treated by vitamin D -May 2014 31 Jul, 2017
Opioid use in palliative cancer patients far less if high level of vitamin D – May 2015 11 May, 2017
Addictive pain relievers Oxycodone and Percocet (not needed as much if have enough vitamin D?) – July 2014 27 Feb, 2017
Vitamin D and Opioids both reduce Magnesium, which results in constipation – Sept 2016 27 Sep, 2016

40,500 hits for (morphine OR opioids OR opiates OR addiction) "vitamin D" in Google Scholar Dec 2023

VitaminDWiki – Pain - chronic category has:

159 items in category Chronic pain

See also

Wikipedia description of Conditioned place preference

"Conditioned place preference (CPP) is a form of Pavlovian conditioning used to measure the motivational effects of objects or experiences. This motivation comes from the pleasurable aspect of the experience, so that the brain can be reminded of the context that surrounded the "encounter". By measuring the amount of time an animal spends in an area that has been associated with a stimulus, researchers can infer the animal's liking for the stimulus."