2.5 X reduced risk of cancer in 70 year-olds by a small amount of Vitamin D, Omega-3 and exercise – RCT April 2022

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Combined Vitamin D, Omega-3 Fatty Acids, and a Simple Home Exercise Program May Reduce Cancer Risk Among Active Adults Aged 70 and Older: A Randomized Clinical Trial

Clinical Trial. Front. Aging 3:852643. doi: 10.3389/fragi.2022.852643

Overall Cancer Reduction vs each intervention

Types of Cancers vs each intervention

SHEP Exercise

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Data charted by GRH (All 3 concurrently were very effective)

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Objective: The aim of this study was to test the individual and combined benefit of vitamin D, omega-3, and a simple home strength exercise program on the risk of any invasive cancer.

Design: The DO-HEALTH trial is a three-year, multicenter, 2x2x2 factorial design double-blind, randomized-controlled trial to test the individual and combined benefit of three public health interventions.

Setting: The trial was conducted between December 2012 and December 2017 in five European countries.

Participants: Generally healthy community-dwelling adults >70years were recruited.

Interventions: Supplemental 2000 lU/day of vitamin D3, and/or 1 g/day of marine omega- 3s, and/or a simple home strength exercise (SHEP) programme compared to placebo and control exercise.

Main outcome: In this pre-defined exploratory analysis, time-to-development of any verified invasive cancer was the primary outcome in an adjusted, intent-to-treat analysis.

Results: In total, 2,157 participants (mean age 74.9 years; 61.7% women; 40.7% with 25- OH vitamin D below 20/ml, 83% at least moderately physically active) were randomized. Over a median follow-up of 2.99 years, 81 invasive cancer cases were diagnosed and verified. For the three individual treatments, theadjusted hazard ratios (HRs, 95% CI, cases intervention versus control) were 0.76 (0.49-1.18; 36 vs. 45) for vitamin D3, 0.70 (0.44-1.09, 32 vs. 49) for omega-3s, and 0.74 (0.48-1.15, 35 vs. 46) for SHEP. For combinations of two treatments, adjusted HRs were 0.53 (0.28-1.00; 15 vs. 28 cases) for omega-3s plus vitamin D3; 0.56 (0.30-1.04; 11 vs. 21) for vitamin D3 plus SHEP; and 0.52 (0.28-0.97; 12 vs. 26 cases) for omega-3s plus SHEP. For all three treatments combined, the adjusted HR was 0.39 (0.18-0.85; 4 vs. 12 cases).

Conclusion: Supplementation with daily high-dose vitamin D3 plus omega-3s, combined with SHEP, showed cumulative reduction in the cancer risk in generally healthy and active and largely vitamin D-replete adults >70 years.
Clinical Trial Registration: ClinicalTrials.gov, Identifier: NCT01745263.
 Study PDF
 SHEP Exercise PDF

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THE DO-HEALTH RESEARCH GROUP

The DO-HEALTH Research Group DO-HEALTH Consortium (in bold: Governing Board members; in bold and underlined: Chair; underlined: Team members).

• Heike A Bischoff-Ferrari, DO-HEALTH Coordinator, Principal Investigator and Zurich Site Investigator, leads all endpoints analyses and co-leads the studies “DO-HEALTH health economic model,” “novel biomarkers of immunity,” “novel biomarkers of muscle and bone communication,” Andreas Egli and Sandrine Rival, University Hospital Zurich, University of Zurich and Waid and Triemli City Hospital, Zurich, Switzerland;
• Bruno Vellas, Toulouse Site Investigator, contributes to the primary endpoint cognitive decline; Sophie Guyonnet, CHU Toulouse and University of Toulouse III, Toulouse, France;
• René Rizzoli, Geneva Site Investigator, contributes to all bone- and muscle-related endpoints and explores the contribution of protein intake to the benefit of the interventions; Emmanuel Biver and Fanny Merminod RD, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland;
• Reto W. Kressig, Basel Site Investigator, contributes to gait analyses and dual task assessments, and Stephanie Bridenbaugh, University Department of Geriatric Medicine FELIX PLATTER and University of Basel, Basel, Switzerland; Norbert Suhm, Department. of Traumatology, University Hospital Basel, contributes to fracture healing study DO-HEALTH;
• José A. P. Da Silva, Coimbra Site Investigator, explores the treatment effects on vertebral fractures, and musculoskeletal pain and function, Centro Hospitalar e Universitario de Coimbra, and Faculty of Medicine, University of Coimbra, Coimbra, Portugal;
  • Catia C. M. Duarte, Centro Hospitalar e Universitario de Coimbra, Coimbra, Portugal; Ana Filipa Pinto R. N., Faculty of Medicine, University of Coimbra, Coimbra, Portugal;
• DieterFelsenberg, Berlin SiteInvestigator, performed the central DO-HEALTH DEXA quality control and evaluation of DEXA measurements;
  • Hendrikje Börst Dipl.Wiss-org, and Gabriele Armbrecht, Charité—Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany;
• Michael Blauth, Innsbruck Site Investigator, explores the functionality after fracture; Anna Spicher, Medical University of Innsbruck, Innsbruck, Austria;
• David T. Felson, co-leads “DO-HEALTH osteoarthritis study,” Manchester Academic Health Science Center, Manchester, United Kingdom and Boston University School of Medicine, Boston, MA, United States;
• John A. Kanis, leads the study “contribution of fall risk to absolute fracture risk within the FRAX model,” University of Sheffield Medical School, Sheffield, United Kingdom and Australian Catholic University, Melbourne, Victoria, Australia;
  • Eugene V. Mccloskey, co-leads the study “contribution of fall risk to absolute fracture risk within the FRAX model,” University of Sheffield, Sheffield, United Kingdom; Helena Johansson, University of Sheffield Medical School, Sheffield, United Kingdom and Catholic University of Australia, Melbourne, Victoria, Australia;
• Bernhard Watzl, co-leads the study “novel biomarkers of immunity,” Manuel Rodriguez Gomez, Max Rubner-Institut, Karlsruhe, Germany;
• Lorenz C. Hofbauer, co-leads the study “novel biomarkers of muscle and bone communication,” Elena Tsourdi and Martina Rauner, Dresden University Medical Center and Center for Regenerative Therapies Dresden, Dresden, Germany;
• Uwe Siebert, co-leads the study “DO-HEALTH health economic model,” UMIT—University for Health Sciences, Medical Informatics and Technology, Hall i.T., Austria and Harvard T. H. Chan School of Public Health, Boston, MA, United States and Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States;
• John A. Kanis, leads DO-HEALTH impact and communication of osteoporosis-related findings on a broad level, and Philippe Halbout PhD, IOF;
• Stephen M. Ferrari, leads DO-HEALTH software development (electronic data capture system and interactive practical software for seniors and healthcare professionals that teaches main findings of DO-HEALTH), Ferrari Data Solutions, Feldmeilen, Switzerland;
• Benno Gut, leads DO- HEALTH visual communication (SHEP avatar) and DO- HEALTH corporate design structures (logo, website software, and communication tools), gut pictures, Horgen, Switzerland;
• Marième Ba, was the DO-HEALTH independent clinical monitoring partner, Pharmalys, Borehamwood, United Kingdom;
• Jonas Wittwer Schegg, industrial partner representative bringing expertise and facilities in plasma analytics for 25-hydroxyvitamin D and omega-3 fatty acids and providing the study medication (vitamin D, omega-3 fatty acids);
  • Stéphane Etheve, DSM Nutritional Products, Kaiseraugst, Switzerland; Manfred Eggersdorfer, University Medical Center Groningen, Gronigen, Netherlands;
• Carla Sofia Delannoy, industrial partner representative providing financial support to DO- HEALTH central coordination, Nestlé Health Science, Lausanne, Switzerland;
• Monika Reuschling, industrial partner representative providing assays for the large DO- HEALTH biomarker study to define reference ranges of common biomarkers in adults aged 70+, Roche diagnostiscs, Rotkreuz, Switzerland.

DO-HEALTH Scientific Advisory Board members and collaborators on specific outcomes

• Endel J. Orav, Harvard T. H. Chan School of Public Health; Boston, MA, United States;
• Walter C. Willett, Harvard T. H. Chan School of Public Health, Boston, MA, United States;
• JoAnn E. Manson, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States;
• Bess Dawson-Hughes, Tufts University, Boston, MA, United States;
• Hannes B. Staehelin, University of Basel, Basel, Switzerland;
• Paul W. Walter, University of Basel, Basel, Switzerland;
• Walter Dick, University of Basel, Basel, Switzerland;
• Michael Fried, University of Zurich, Zurich, Switzerland;
• Arnold von Eckardstein, University of Zurich, Zurich, Switzerland;
• Robert Theiler, University Hospital Zurich and University of Zurich, Zurich, Switzerland;
• Hans-Peter Simmen, University of Zurich, Zurich, Switzerland;
• Wolfgang Langhans, ETH Zurich, Zurich, Switzerland;
• Annelies Zinkernagel, University Hospital of Zurich, Zurich, Switzerland;
• Nicolas Mueller, University Hospital of Zurich, Zurich, Switzerland;
• Oliver Distler, University Hospital of Zurich, Zurich, Switzerland;
• Klaus Graetz, University Hospital of Zurich, Zurich, Switzerland;
• Ina Nitschke, University Hospital of Zurich, Zurich, Switzerland;
• Thomas Dietrich, University of Birmingham, United Kingdom;
• Walter Baer, University of Zurich, Zurich, Switzerland;
• Klara Landau, University Hospital of Zurich, Zurich, Switzerland;
• Frank Ruschitzka, University Hospital of Zurich, Zurich, Switzerland;
• Markus Manz, University Hospital of Zurich, Zurich, Switzerland;
• Peter Burckhardt, University of Lausanne, Lausanne, Switzerland.

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Could have had better results if any combination of :
1) Had used larger doses of Vit D, Omega-3,
2) Had used non-daily Vitamin D.
3) Had allowed months between intervention and start counting Cancer events
4) Had give even larger doses to obese
5) Had used a gut-friendly form of vitamin D (especially for those with poor guts)
6) Had decreased Omega-6 consumption
7) Had also given Mg (increases Vitamin D response by 40%)

1) VitaminDWiki pages with HIGH-DOSE in title (63 as of April 2022)
This list is automatically updated

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2) Better than Daily
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3) Had waited for Vitamin D to get to useful levels

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4) Obese need 2.5X more vitamin D

• Normal weight     Obese     (50 ng = 125 nanomole)

Click here to see the 2014 study
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5) Gut-Friendly Vitamin D

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18+ VitaminDWiki Omega-3 pages have CANCER in the title

This list is automatically updated

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VitaminDWiki - Overview Breast Cancer and Vitamin D contains

• 24 Meta-analyses of Vitamin D and Breast Cancer
    example: 2X reduction of deaths from Breast Cancer if have enough Vitamin D.
• Appears that having lots of Vitamin D will reduce by 3 X the chance of Breast Cancer
     wonder just how much more proof is needed
• Breast Cancer 4X more likely if have poor genes
•     Cancer - Breast category listing has 252 items along with related searches
• Breast Cancer treatment – Vitamin D was the most-popular supplement – Jan 2023
• Breast Cancer again associated with low vitamin D – 15th meta-analysis Sept 2020
• Vitamin D reduced Breast Cancer mortality in 9 out of 9 studies, yet still no consensus – April 2019
• Vitamin D both prevents and treats Breast Cancer – 2019

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VitaminDWiki - Cancer category contains

• Cancer 282 items Overview Cancer and vitamin D
• Cancer and Vitamin D - many studies
• After Cancer Diagnosis 110 items
• Bladder Cancer 26 items
• Breast Cancer 252 items Overview Breast Cancer and Vitamin D
• Colon Cancer 141 items Overview Cancer-Colon and vitamin D
• Leukemia 19 items
• Liver Cancer 17 items
• Lung Cancer 54 items Overview Lung cancer and vitamin D
• Lymphoma Cancer 25 items
• Other Cancer 66 items
• Ovarian Cancer 25 items
• Pancreatic Cancer 55 items
• Prostate Cancer 101 items Overview Prostate Cancer and Vitamin D
• Skin Cancer 120 items Overview Suntan, melanoma and vitamin D
• Childhood Cancers - Vitamin D can help - many studies
• Easiest way to treat cancer – take Vitamin D – Nov 2022
• 13 Cancers are helped by Vitamin D – Biobank July 2023
• 2X increase of 14 cancers in non-seniors in 20 years (low vitamin D) – Sept 2022
• Vitamin D prevents and treats cancer in many ways – May 2021
• Those with recent cancer diagnosis had 7X increased risk of COVID-19 (more if A-A )- Dec 2020
• Deaths from many types of Cancer associated with low vitamin D- review of meta-analyses Sept 2020
• Cancer incidence and mortality is decreased if 40-60 ng of Vitamin D – April 2019
• 8 ways that Cancer might be prevented by Vitamin D - June 2019
• Cancer stem cells and Vitamin D - many studies
• Vitamin D Reduces Cancer Risk - Why Scientists Accept It but Physicians Do Not - Feb 2019
• Overview of Vitamin D Actions in Cancer – 31 page chapter in a book – 2018
• Vitamin D prevents breast cancer, reduces BC mortality, and reduces BC chemotherapy problems – Sept 2018
• Diagnosed with breast cancer – take vitamin D to cut chance of death by half – July 2018
• Melanoma 25 X more likely if low vitamin D – Feb 2018
• Better Cancer survival if higher vitamin D a decade earlier (esp. Melanoma, Kidney, Prostate)– Aug 2018

Cancers get less Vitamin D when there is a poor Vitamin D Receptor

• Vitamin D Receptor pages in VitaminDWiki with CANCER in title 86 as of July 2023
• Cancer and the Vitamin D Receptor, a primer – Sept 2017
• Vitamin D Receptor (Cancers OR Viruses) - many studies
• Risk of Cancer increased if poor Vitamin D Receptor – meta-analysis of 73 studies Jan 2016
• Cancer (general) and VDR 23 articles
• Breast Cancer and VDR 22 articles
• Colon Cancer and VDR 13 articles
• Prostate Cancer and VDR 7 articles
• Skin Cancer and VDR 10 articles
  • Note some Health problems, such as some Cancers, protect themselves
    by actively reducing Receptor activation

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VitaminDWiki - Cancer - Colon category contains

• Cancer - Colon category listing has 141 items

• see also:
  Overview Cancer-Colon and vitamin D.   Overview Cancer and vitamin D  Overview Gut and vitamin D   Cancer and Vitamin D - many studies
• Cancer - After diagnosis category listing has 110 items along with related searches
• 16 factors increase the risk of early-onset colorectal cancer, only vitamin D decreases the risk – meta-analysis May 2023
• Colorectal cancer 14 percent less likely if 10 ng more Vitamin D – 22nd meta-analysis – Sept 2022
• Colon cancer risk increases 30X if you have the worst vitamin D receptor mutation – Jan 2021

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66+ VitaminDWiki pages have EXERCISE in the title

This list is automatically updated

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Vitamin D is the 3rd best way to improve your health (but the most cost-effective)