A phase IV, two-armed, randomized, cross-over study comparing compliance with once-a-month administration of vitamin D3 to compliance with daily administration of a fixed-dose combination of vitamin D3 and calcium during two 6-month periods.
Osteoporos Int. 2015 Dec;26(12):2863-8. doi: 10.1007/s00198-015-3205-z. Epub 2015 Jun 23.
Bruyère O1, Deroisy R2, Dardenne N3, Cavalier E4, Coffiner M5, Da Silva S5, De Niet S5, Reginster JY3.
1Support Unit in Epidemiology and Biostatistics, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, 4000, Belgium. olivier.bruyere at ulg.ac.be.
2Médecine Appareil Locomoteur, CHU Liège, BRULL, Liège, Belgium.
3Support Unit in Epidemiology and Biostatistics, Department of Public Health, Epidemiology and Health Economics, University of Liège, Liège, 4000, Belgium.
4Department of Clinical Chemistry, University of Liège, Liège, Belgium.
5SMB Belgium, Brussels, Belgium.
25,000 IU monthly was better than daily 800 IU (which included daily Calcium)
- 57% preferred the monthly dosing (18% preferred daily)
- Monthly dosing resulted in higher levels of vitamin D
increase 7 ng vs 4 ng – not statistically significant.
Perhaps due to lower daily compliance
- No difference in adverse events between monthly and daily dosing
See also VitaminDWiki
- One pill every two weeks gives you all the vitamin D most adults need
- 43 pages have the word MONTHLY in the title - Sept 2016
- Vitamin D once every two weeks is OK, daily is nice but not required – Aug 2014
- Bone loss not stopped by monthly 48,000 IU of vitamin D – RCT June 2016
- Vitamin D RCT using 100,000 IU monthly for a variety of health problems – results of ViDA due in 2016
- Falls cut in half by 100,000 IU vitamin D monthly - RCT 2016
- COPD reduced by 40 percent with monthly 100,000 IU of vitamin D – RCT Jan 2015
- Prediabetes reduced by monthly 60,000 IU of vitamin D – RCT May 2015
- Graph of weekly response to monthly vitamin D supplementation – Aug 2015
- Response to 150,000 IU vitamin D once vs 5,000 IU daily – RCT May 2014
- Take vitamin D3 daily, weekly, or bi-weekly has the following for levels < 30 ng
Download the PDF from VitaminDWiki
In a randomized, cross-over study, once monthly administration of vitamin D3 was preferred over a once daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better compliance but without any significant difference in the increase in vitamin D levels.
The aim of the present study was to compare a once-monthly administration of vitamin D3 to a daily administration of a fixed-dose combination of vitamin D3 and calcium during two treatment periods of 6 months.
One hundred volunteers aged 50 years old or older were randomized to receive either one drinkable ampoule containing 25,000 IU vitamin D3 (D-Cure®, SMB) once monthly (group VD) or one chewable tablet containing 1000 mg calcium carbonate + 800 IU vitamin D3 (Steovit Forte®, Takeda) once daily (group VDCa) during 6 months. After the first 6 months of treatment, the groups were reversed according to the randomized cross-over design. Treatment compliance (i.e. the primary outcome), preference, acceptability and vitamin D levels and adverse events were all collected.
For the two periods, the patients had a significantly higher compliance in the VD group than in the VDCa group (p < 0.0001). During the study, 50 (56.8 %) patients preferred the VD treatment, 16 (18.2 %) patients preferred the VDCa, and for 22 (25.0 %) patients, neither treatment was preferred. At the end of the first 6 months of treatment, the mean (SD) increase of 25(OH)D was 6.57 ng/mL (8.19) in the VD group and 3.88 ng/mL (10.0) in the VDCa group (p = 0.16 between groups).
In this study, a once-monthly administration of vitamin D3 was preferred over a once-daily administration of a fixed-dose combination of vitamin D3 and calcium, with a better compliance but without any significant difference in the increase in vitamin D levels.
PMID: 26100413 PMCID: PMC4656705 DOI: 10.1007/s00198-015-3205-z