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How often might 50,000 IU vitamin D be taken - results of clinical trials

There have been many extremely successful vitamin D intervention trials.
Often the trials are random-controlled and double-blind: neither the doctor nor the subject knows who gets it
The trials listed in the following table are sorted by the number of days between doses of 50,000 IU.
It appears that the higher the dose of vitamin D, the more diseases which are prevented or treated.

50,000 IU
Health ProblemPrevent
Reduction in
symptoms or
number of people
with symptoms
RCT = Random Controlled Trial
CT = Clinical Trial
Proof #*
2Traumatic Brain InjuryT 2X RCT, 20,000 IU24
2Raynaud's SyndromeT 40 %RCT, visual scale10
2Multiple SclerosisR95% RecoveredCT, 20K-140,K IU/day +Vit B243
3Sickle CellT Less painRCT up to 100,000 IU/week22
4Sleep disorderRRecoveredCT, 60-80 ng +Vit B12 
5Muscle fatigueT ReducedCT, 20,000 IU every 2nd day 
5Back PainT 95% reducedCT, 5,000-10,000/day 
5Cluster HeadachesR80% curedCT, 10,000/day+ Omega-3 etc. 
5Parkinson's DiseaseT Ongoing Trial RCT, 50,000 IU/week 
7Leg ulcer healingT 4X fasterRCT, 50,000 IU/week small study23
7Menstrual painP 76 %RCT, 7000 IU avg11
7Skin problems resolvedT 70 %RCT, 50,000 IU/week 
7FibromyalgiaT Significantly reducedRCT, 50,000 IU/week 
7Multiple SclerosisP 68%RCT, 7100 IU prevent pre-MS ==> MS26
7Chronic Obstructive Pulmonary DiseaseT 17X improvementCT (not random), 50,000 IU/week45
9Chronic kidney disease T 50 % not need dialysisRCT, 40,000 IU / week 
9Gestational DiabetesP 40%RCT, 5,000 IU44
9Low vitamin D while breastfedP All > 20 ngRCT, 5,000 IU38
10PAINT not yet publishedClinical Trial, 34,590 IU/week 
12Diabetes T2T 62 %RCT, CRP reduction, 4000 IU4
12Pregnancy risksP 50 %RCT, 4000 IU12
12C-section, unplannedP 50 %RCT, 4000 IU, small study13
12Respiratory Tract InfectionP 63 %RCT 4000 IU 1 year20
12Prostate CancerT Fewer +coresRCT, 4000 IU (2012)35
12Hives, ChronicT Reduced 40%RCT, 4000 IU added40
12Muscle in seniorsT +17 %RCT, 4000 IU30
14FibrolyalgiaT ReducedRCT, 30-48 ng39
15LupusT No flaresLoad then 100,000/month21
 Note: due to short half life, should not take 50,000 IU any less frequently than about 18 days
21HypertensionT 149 to 142RCT, mm Hg avg., 2400 IU1
25InfluenzaP 90 %RCT, 2000 IU6
25GingivitisT 88 %RCT, 2000 IU29
25Antibiotic use when >70yT 47 %RCT, 60,000 IU/month31
25Weight LossT Reduced extra 5 lbsRCT, 2000 IU +diet +exercise42
30AsthmaT ReducedRCT, 60,000 IU/month36
45Parkinson's DiseaseT StabilizeRCT, 1200 IU25
45Breast CancerP 60 %RCT 1100 IU16
50CardiovascularT 32 % fewer deaths
after heart failure
CT, 1,000 IU 
50CholesterolT Reduced 4 mgRCT, 400 IU + Ca41

   * Proof # Vitamin D Proof: Random controlled Trials  Updated May 2014

PDF is attached at the bottom of this page June 2014 1pg Legal English

The following curve indicates that you probably want to take 50,000 IU of vitamin D at least every two weeks.

50000 IU monthly is not a lot

Notes on 50,000

  • Lowest-cost form of vitamin D3 (about 2 cents per 5,000 IU)
  • The half-life of vitamin D3 is measured in weeks - so taking 50,000 every few weeks is OK (the half-life of vitamin D2 is measured in days)
  • This is the size of vitamin D that doctors have been used to prescribing for many decades - generally as a loading dose every week or two.
  • Now doctors can prescribe Vitamin D3 instead of D2
  • This has very low toxicity - even if accidentally taken daily, the toxicity does not occur until it has been taken daily for 3 months
  • It can even be used by those who cannot swallow pills (the powder in the capsule is tasteless and can be taken directly or in food or beverage

Cofactors appear to be needed if dosing more frequently than every 20 days for months

Easy to remember to take vitamin D - just mark your calendar

Bio-Tech Pharmacal started selling its 50,000 IU vitamin D capsules in the US in 2000.
As of March 2012, their 50,000 IU size was widely available in the US and on the internet.
They also sell 5,000 IU capsules. The 5,000 IU and 50,000 IU sizes are available both over the counter and as a prescription. These are NOT new products.
It is available on the internet via many suppliers, such as Amazon $20 for 100 capsules.
Bio-Tech has supplied products to over 40 institutions for use in clinical research, usually at no cost
The PDF attached at the bottom of this page details their US and international distributors as of Sept 2012.
The wholesale cost of 50,000 IU of D3 is about 15 cents. (D2. which doctors previously prescribed is much more expensive and not nearly as good
Their capsules are made from beef (non-pork: Kosher/Halal approved)
Vegi capsules (without beef) are available but are more expensive

As of Feb 2013, Bio-tech is 1 of 2 suppliers of 50,000 IU on Amazon (there is another company that has 25,000 IU capsules
As of Oct 2012, there were 41 public clinical trials using/had used Bio-Tech supplements
   28 of the clinical trials used 50,000 IU of vitamin D

    Summary is attached as a PDF file at the bottom of this page

See also VitaminDWiki

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Created by admin. Last Modification: Friday September 8, 2023 01:30:45 GMT-0000 by admin. (Version 138)
How often might 50,000 IU vitamin D be taken - results of clinical trials        
10915 visitors, last modified 08 Sep, 2023,
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Attached files

ID Name Comment Uploaded Size Downloads
4033 50,000 timing June 2014 1pg Legal English.pdf admin 12 Jun, 2014 22.49 Kb 2715
1647 Clinical Studies Utilizing Bio-Tech Products - Oct 2012.pdf admin 09 Oct, 2012 151.71 Kb 4870
1600 Bio-Tech suppliers Sept 2012.pdf admin 16 Sep, 2012 88.94 Kb 3992