Clin Orthop Relat Res. 2013 Nov;471(11):3556-62. doi: 10.1007/s11999-013-3201-6. Epub 2013 Aug 1.
Sanghi D1, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, Srivastava RN.
1Department of Orthopaedic Surgery, King George's Medical University, Nabiullah Road, near Daliganj Chauraha, Lucknow, India.
Trial limited to those with < 20 ng of Vitamin D
Loading dose of 60,000 IU per day for 10 days (600,000 IU)
Followed by 60,000 IU once a month for 12 months
See also VitaminDWiki
- Overview Osteoarthritis and Vitamin D
- Search VitaminDWiki for "Knee Osteoarthritis" 373 items as of Oct 2018
- Less Knee Osteoarthritis if take more Vitamin D – 8 MRI confirmations – Nov 2018
- Synovitis (knee osteoarthritis) associated with low vitamin D – Dec 2016
- Knee osteoarthritis strongly associated with low Boron – 2015
- Far fewer joint problems (Osteochondrosis) when Boron was added to diet (pigs)
- Knee joint space narrowing (Osteoarthritis) 1.5X worse with low vitamin D – meta-analysis Sept 2015
- Knee Osteoarthritis (Radiographic ) 3X less if have lots of Magnesium – May 2015
- Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
- I needed more than Vitamin D to treat my knee osteoarthritis
My Knee Osteoarthritis is gone: Vitamin D, Boron, and Magnesium (both orally and topically)
- Overview Loading of vitamin D
Get the benefits in weeks instead of many months with a Vitamin D loading dose
It is not possible to have internal loading doses of Magnesium, topical works great
Pain - chronic category has the following
- Overview Pain and Vitamin D
- Overview Fibromyalgia or Chronic Fatigue and vitamin D
- Overview Rheumatoid Arthritis and vitamin D
- Shingles and vitamin D
- Shin splints decrease with vitamin D
- Migraine and Vitamin D
- Headache category
- "musculoskeletal pain" 374 items as of March 2018
- "chronic fatigue" 185 items as of Jan 2017
- Category Back Pain
- 5 pain studies in VitaminDWiki with KNEE in the title as of Feb 2022 (see below)
- Opioid OR Opiate OR Morphine in the title 10 pages as of June 2021
Animal, epidemiologic, and human clinical studies suggest a putative role for vitamin D in osteoarthritis (OA). Inadequate sunlight exposure and lower serum levels of 25(OH)D appear in some reports to be associated with an increased risk for progression of knee OA.
We asked whether treatment with vitamin D would (1) reduce knee pain (WOMAC and VAS), (2) improve function (WOMAC), and (3) change levels of relevant biochemical markers in patients with knee OA with vitamin D insufficiency.
This randomized controlled pilot trial prospectively enrolled 107 patients with knee OA with vitamin D insufficiency (25(OH)D = 50 nmol/L) to receive oral vitamin D or placebo. The primary outcome measures were pain and function, and the secondary were biochemical markers. At baseline, the two groups were comparable. The patients were followed for 1 year.
At 12 months, knee pain had decreased in the vitamin D group by mean -0.26 (95% CI, -2.82 to -1.43) on VAS and -0.55 (95% CI, -0.07 to 1.02) on the WOMAC, whereas in the placebo group, it increased by mean 0.13 (95% CI, -0.03 to 0.29) on the VAS and 1.16 (95% CI, 0.82 to 1.49) on the WOMAC (effect size = 0.37 and 0.78). Likewise knee function improved in the vitamin D group by mean -1.36 (95% CI, -1.87 to -0.85) over the placebo group which had a mean 0.69 (95% CI, -0.03 to 1.41; effect size = 0.06). There were significant biochemical changes in serum total calcium, 25(OH)D and alkaline phosphatase.
The results above suggest there is a small but statistically significant clinical benefit to vitamin D treatment in patients with knee OA, although we recommend a long-term study to determine whether these changes are clinically important and whether they will be sustained with time. Further studies with long-term radiologic evaluations are needed.
CORR Insights ®: Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013
Reply to the Letter to the editor: Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013
Letter to the editor: Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial. Clin Orthop Relat Res. 2013
PMID: 23904246 PMCID: PMC3792285 DOI: 10.1007/s11999-013-3201-6Knee osteoarthritis pain reduced by 60,000 IU monthly vitamin D following loading dose – RCT Nov 2013
5690 visitors, last modified 10 Oct, 2018,This page is in the following categories (# of items in each category)