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50,000 IU Vitamin D weekly was the most popular for Breast Cancer - May 2020

Practical Vitamin D Supplementation Using Machine Learning

J Bone Metab. 2020 May;27(2):111-117. doi: 10.11005/jbm.2020.27.2.111
Tyler Fugere 1, Zhongning Jim Chen 1, Issam Makhoul 1


Women with breast cancer.
Wrongly considered than 20 ng was a high enough level of vitamin D
Need more to get to 30 ng of 40 ng
Need more if overweight or obese
Unclear how long for the vitamin D levels to plateau
There may be a on-line calculator - investigating

  • One pill every two weeks gives you all the vitamin D most adults need
    • Every 2 weeks Diabetes + Heart Failure + Chronic Pain + Depression + Autism + Breast Cancer + Colon Cancer + Prostate Cancer + Preeclampsia + Premature Birth + Falls + Cognitive Decline + Respiratory Tract Infection + Influenza + Tuberculosis + Chronic Obstructive Pulmonary Disease + Lupus + Inflammatory Bowel Syndrome + Urinary Tract Infection + Poor Sleep + Weight Loss + Growing Pain   (22 problems)

18 additional Health Problems fought when taking 50,000 IU Vitamin D weekly

ADHDAttention-Deficit Hyperactivity Disorder treated by weekly 50,000 IU of vitamin D – RCT Nov 2018
Asthma Asthma reduced by weekly 50,000 IU of vitamin D – RCT Aug 2014
Depression Depression in adolescent girls reduced somewhat by 50,000 IU weekly for 9 weeks – July 2017
Diabetic Nephropathy Diabetic nephropathy (Kidney) treated by 50,000 IU of vitamin D weekly – RCT Jan 2019
Hashimoto's thyroiditis Hashimoto's thyroiditis helped by weekly 50,000 IU of vitamin D – RCT May 2019
Hay FeverHay Fever treated by Vitamin D (50,000 IU weekly) – RCT July 2019
Hives Hives treatment augmented by 60,000 IU Vitamin D weekly – RCT June 2015
Hypertension – pulmonaryPulmonary hypertension reduced in some people with weekly 50,000 IU vitamin D for 3 months – 2016
Kidney Disease Hemodialysis patients (CKD) helped by weekly 50,000 IU of vitamin D – Jan 2017
Migraine Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015
Multiple Sclerosis relapse No multiple sclerosis relapses during pregnancy if 50,000 IU of Vitamin D weekly – RCT April 2015
Osteoarthritis – knee Knee osteoarthritis treated with vitamin D, weekly 50,000 IU – May 2015
Pain - Back Chronic Back Pain relieved by weekly 60,000 IU of vitamin D – Jan 2017
Pain – Chronic 7 improvements in lives of veterans with chronic pain with 50,000 IU vitamin D weekly – June 2012
Pain – Fibromyalgia Fibromyalgia treated with Vitamin D (50,000 IU weekly for 3 months) – 2016, 2017, 2018, 2019
PMS PMS in teens reduced 3X by 50,000 IU vitamin D weekly – Jan 2018
Sports PerformanceAthletes helped by weekly 50,000 IU Vitamin D – RCT Aug 2019
Ulcers – Venous Venous ulcers healed 4X faster with weekly 50,000 IU vitamin D – RCT Oct 2012

 Download the PDF from VitaminDWiki

Background: Patients with breast cancer are at increased risk of developing osteoporosis. Maintaining normal levels of vitamin D may decrease the risk of osteoporosis, and vitamin D levels must be corrected in patients who develop osteoporosis before beginning bone modifying agents. Therefore, it is important to correct insufficient vitamin D levels in a timely manner. In clinical practice, current guidelines for replacement regimens often fail to rapidly correct vitamin D levels. The goal of this study was to review data in order to predict what replacement regimen(s) were most effective at repleting vitamin D levels.

Methods: For this retrospective cohort study, data was collected from medical records of 2,164 female patients with breast cancer with Institutional Review Board approval. Total level change per week was the primary outcome and was compared for the most commonly used vitamin D replacement regimens adjusted for age, race, body mass index, creatinine clearance, endocrine therapy, and initial level.

Results: Higher weekly doses of vitamin D supplementation had a more significant impact on the rate of correction compared to lower daily doses. Generalized linear model was used to develop an online calculator that predicts time to vitamin D level correction adjusted for significant patient characteristics for 5 common replacement regimens as well as no intervention.

Conclusions: When choosing a vitamin D replacement regimen for patients with vitamin D deficiency, we recommend clinicians use the online calculator to ensure that the chosen regimen will enable the patient to reach vitamin D sufficiency in a timely manner.

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Attached files

ID Name Comment Uploaded Size Downloads
13950 Predict chart.jpg admin 24 Jun, 2020 18:02 30.96 Kb 479
13949 Machine learning to predict Vitamin D.pdf PDF 2020 admin 24 Jun, 2020 17:48 394.91 Kb 447