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Vitamin D for infants – 100,000 IU monthly is better than 400 IU daily – RCT Oct 2020

Effect of vitamin D supplementation as a single dose on the nutritional status of vitamin D

Revista Chilena de Pediatría 2020, 91 (5): 684-690 (study is in Spanish)
Johanna Pacheco-Acosta, Fernando Pizarro


100K was better because more of them have vitamin D levels between 30 and 40 ng

Infant-Child category has 693 items and starts with

Having a good level of vitamin D cuts in half the amount of:

Need even more IUs of vitamin D to get a good level if;

  • Have little vitamin D: premie, twin, mother did not get much sun access
  • Get little vitamin D: dark skin, little access to sun
  • Vitamin D is consumed faster than normal due to sickness
  • Older (need at least 100 IU/kilogram, far more if obese)
  • Not get any vitamin D from formula (breast fed) or (fortified) milk
    Note – formula does not even provide 400 IU of vitamin D daily

Infants-Children need Vitamin D

  • Sun is great – well known for 1,000’s of years.
    US govt (1934) even said infants should be out in the sun
  • One country recommended 2,000 IU daily for decades – with no known problems
  • As with adults, infants and children can have loading doses and rarely need tests
  • Daily dose appears to be best, but monthly seems OK
  • Vitamin D is typically given to infants in the form of drops
       big difference in taste between brands
       can also use water-soluable form of vitamin D in milk, food, juice,
  • Infants have evolved to get a big boost of vitamin D immediately after birth
    Colostrum has 3X more vitamin D than breast milk - provided the mother has any vitamin D to spare
  • 100 IU per kg of infant July 2011, Poland etc.
    1000 IU per 25 lbs.jpg
    More than 100 IU/kg is probably better

Did you know that:

Getting Vitamin D into infants
Many infants reject vitamin D drops, even when put on nipple
I speculate that the rejection is due to one or more of: additives, taste, and oils.
Infants have a hard time digesting oils, 1999  1997   and palm oils W.A. Price 1 2 3
Coconut oil, such as in D-Drops, is digested by infants. 1,   2   3
Bio-Tech Pharmacal Vitamin D has NO additves, taste, nor oil
One capsule of 50,000 Bio-Tech Pharmacal Vitamin D could be stirred into monthly formula or given once a month
   this would result in ~1,600 IUs per day for infant, and higher dose with weight/age/formula consumption

Better than Daily category listing has 25 items

Items in both categories Infant-Child and Intervention - non daily are listed here:

 Download the PDF from VitaminDWiki

INTRODUCTION: Infants are a group at risk of vitamin D (VD) deficiency. The administration of 400 IU of VD per day during the first year of life does not achieve 100% adherence. A single dose of 100,000 IU of oral VD is safe in newborns.

OBJECTIVE: To compare the effect of oral administration of VD between a single dose of 100,000 IU at one month of age vs daily doses of 400 IU on serum concentrations of VD, at 6 months of age.

SUBJECTS AND METHOD: Randomized clinical trial, without masking. 84 healthy infants were included at 1 month of age, randomized to the study group (SG) receiving a single oral dose of 100,000 IU or to the control group (CG), who received daily oral doses of VD of 400 IU from the 1st to the 6th month of life. At 6 months of life, the serum concentration of VD was determined.

RESULTS: 65 infants completed the study, 36 in SG and 29 in CG. No VD deficiency was found.
VD insufficient was 5.5% and 6.8% in the SG and CG, respectively.
The serum concentration of VD at six months of age was 38.8 ± 5.2 ng/ml and 39.7 ± 6.3 ng/ml for the SG and CG, respectively (NS).

CONCLUSIONS: Supplementation of 100,000 IU of VD at one month age achieves serum concentrations of VD at 6 months of life similar to the administration of daily doses of 400 IU of VD from the 1st to the 6th month.
- - - - - Clipped from PDF- - - - -
A randomized clinical trial was conducted, without blinding, which included 84 healthy infants (42 per group) between August 15, 2015, and July 15, 2016, who attend well-baby checkups at the Padre Vicente Irarrázaval Family Health Center (CESFAM), Santia go (Latitude 33°S). We included full-term newborns between 25 and 45 days of age, fed with exclusive or mainly breast milk, with the written informed consent of their parents or representative of legal age.

Created by admin. Last Modification: Sunday January 10, 2021 02:35:20 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
14840 100K monthly.jpg admin 10 Jan, 2021 01:32 28.64 Kb 201
14839 100K English.pdf PDF 2020 admin 10 Jan, 2021 01:31 511.59 Kb 151
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