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Diabetic inflammation synergistically decreased by Vitamin D and exercise – RCT June 2022

Concurrent alteration in inflammatory biomarker gene expression and oxidative stress: how aerobic training and vitamin D improve T2DM

BMC Complement Med Ther. 2022 Jun 22;22(1):165. doi: 10.1186/s12906-022-03645-7.
Rastegar Hoseini 1, Hiwa Ahmed Rahim 2, Jalal Khdhr Ahmed 2


BMI 25-30, 8 weeks Aerobic, 50,000 IU weekly

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Background: Vitamin D (Vit D) supplementation and Aerobic Training (AT) exert several beneficial effects such as antioxidant and anti-inflammatory actions. The literature on the effects of AT and Vit D supplementation on the oxidative stress biomarkers and gene expression of inflammatory cytokines in patients with Type 2 Diabetes Mellitus (T2DM) is limited. The present study aimed to examine the effects of AT and Vit D supplementation on inflammation and oxidative stress signaling pathways in T2DM patients.

Materials and methods: In this single-blinded, randomized, placebo-controlled trial, 48 men with T2DM (aged 35-50 years with Body Mass Index (BMI) of 25-30 kg/m2) were randomly allocated into four groups: AT+Vit D (n = 10); AT + placebo (AT; n = 10); Vit D (n = 10), and Control + placebo (C; n = 10). The eight-week AT program was executed for 20-40 min/day, at 60-75% of heart rate maximum (HRmax), for 3 days/wks. The Vit D group received 50,000 IU of Vit D supplement capsules per week for 8 weeks. The serum levels of oxidative stress biomarkers and gene expression of inflammatory cytokines in the Peripheral Blood Mononuclear Cells (PBMCs) were evaluated using the RT-PCR method. To analyze the data, paired t-tests and one-way analysis of variance and Tukey's post hoc test were used at the significance level of P < 0.05.

Results: The result shows that serum 25-OH-Vit D, total nitrite, Total Glutathione (GSH), Total Antioxidant Capacity (TAC), Superoxide Dismutase (SOD), Catalase (CAT), and Glutathione Peroxidase (GPX) increased; and insulin, Fasting Blood Glucose (FBG), Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), High Sensitivity C-Reactive Protein (hs-CRP), Malondialdehyde (MDA), glycated albumin, and Urinary 8-hydroxydeoxyguanine (8-OHdG) decreased significantly in all groups after 8 weeks, except for C. In addition, results of RT-PCR showed that AT+Vit D, Vit D, and AT significantly downregulated the gene expression of Tumor Necrosis Factor-Alpha (TNF-α), Interleukin-1 Beta (IL-1β), Mitogen-Activated Protein Kinases 1 (MAPK1), Nuclear Factor Kappa B (NF-κB) 1 (p50). It also upregulated Interleukin-4 (IL-4) gene expression, Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) in T2DM patients compared to the C.

Conclusion: Additionally, the AT+Vit D group showed significantly lower insulin, FBG, HOMA-IR, hs-CRP, MDA, glycated albumin, urinary 8 - OHdG, IL-1β, TNF-α, MAPK1, and NF-κB1 (p50) levels and significantly higher serum 25-OH-Vit D, total nitrite, GSH, TAC, CAT, SOD, GPX, IL-4, and PPAR-γ levels compared to the AT and Vit D groups. In T2DM patients, 8 weeks of AT+Vit D had a more significant impact on certain gene expressions related to inflammation and oxidative stress than Vit D or AT alone.
 Download the PDF from VitaminDWiki

Same authors had a very similar publication in Oct 2022

Decreased inflammatory gene expression m accompanies the improvement of liver enzyme and lipid profile following aerobic training and vitamin D supplementation in T2DM patients
BMC Endocrine Disorders Hoseini et al. BMC Endocrine Disorders (2022) 22:245 https://doi.org/10.1186/s12902-022-01152-x
 Download the PDF from VitaminDWiki

8 studies in both categories Diabetes and Inflammation

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Even better results expected if started Vitamin D a month earlier with Omega-3 and VDR activator

VitaminDWiki - Overview Diabetes and vitamin D contains

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 540 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

Number of articles in both categories of Diabetes and:
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  • Dark Skin 24;   Intervention 56;   Meta-analysis 38;   Obesity 35;  Pregnancy 44;   T1 (child) 39;  Omega-3 11;  Vitamin D Receptor 24;  Genetics 12;  Magnesium 27    Click here to see details

Some Diabetes studies

50 ng of Vitamin D fights Diabetes

T1 Diabetes


Diabetes, Metabolic Syndrome and Magnesium - many studies

Diabetic Epidemic

  • Step back to 1994. Suppose an epidemic struck the United States, causing blindness, kidney failure, and leg amputations in steadily increasing numbers.
    Suppose that in less than a decade's time, the epidemic had victimized one out of every eight people
    That epidemic is real, and its name is diabetes, now the nation's sixth leading cause of death.
    Chart from the web (2018?)

VitaminDWiki - 22 studies: Diabetes and non-daily Intervention (often RCT)

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VitaminDWiki - 4 studies in both categories Diabetes and Sports

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VitaminDWiki - 11 studies in both categories Diabetes and Omega-3

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Many health problems treated when Vitamin D Receptor is activated (very low cost)

Activation of the VDR gets more Vitamin D to the cells

VitaminDwiki – Better than Daily category has 31 items weekly or biweekly often better than daily

Many studies find that exercise + Vitamin D reduce diabetes

Importance to Health VDW10426
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Attached files

ID Name Comment Uploaded Size Downloads
18598 Diabetes Vit D and exercise_CompressPdf.pdf admin 09 Oct, 2022 326.45 Kb 122
17945 NF.jpg admin 23 Jun, 2022 30.34 Kb 249
17944 TNF.jpg admin 23 Jun, 2022 26.75 Kb 253
17943 PPARy.jpg admin 23 Jun, 2022 34.94 Kb 244
17942 IL-4.jpg admin 23 Jun, 2022 36.39 Kb 232
17941 MAPK1.jpg admin 23 Jun, 2022 29.56 Kb 254
17940 IL.jpg admin 23 Jun, 2022 29.87 Kb 264
17939 D plus aerobic for T2DM.jpg admin 23 Jun, 2022 79.62 Kb 325
17938 Vit D plus aerotic traiing T2DM_CompressPdf.pdf admin 23 Jun, 2022 389.20 Kb 175