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Stoss (loading) dose of vitamin D resulted in bigger response at 30 days (again) – RCT April 2021

Stoss therapy is safe for treatment of vitamin D deficiency in pediatric patients undergoing HSCT

Bone Marrow Transplant. 2021 Apr 19. doi: 10.1038/s41409-021-01294-x
Jessica Bodea 1, Kristen Beebe 2 3, Courtney Campbell 2, Dana Salzberg 2, Holly Miller 2, Roberta Adams 2 3, Lucia Mirea 2, Paul Castillo 4, Biljana Horn 4, Sandhya Bansal 5, Thalachallour Mohanakumar 5, Alexander Ngwube 6 7

Study used 100,000 to 600,000 IU
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Vitamin D deficiency remains common among pediatric patients undergoing hematopoietic stem cell transplant (HSCT) despite both aggressive and standard of care strategies. This study examined the safety and efficacy of single high-dose oral vitamin D therapy (Stoss therapy) for treatment of vitamin D deficiency in HSCT recipients. Patients ages 1-21 years presenting for HSCT were randomized to receive either Stoss regimen plus weekly/daily supplementation or standard of care, per US Endocrine Society guidelines. Among the total 48 subjects, 22 (46%) were randomized to Stoss and 26 (54%) to control arms. Baseline 25-hydroxyvitamin D (25-OHD) levels were insufficient/deficient in total of 34 (71%) patients, without difference between treatment groups. The Stoss regimen was well tolerated and no toxicity was observed. At Day +30, mean 25-OHD levels were significantly higher (P = 0.04) with Stoss (42.3 ± 12 μg/l) compared to controls (35.6 ± 14.3 μg/l), and a higher proportion of Stoss patients had adequate vitamin D levels than controls (85% vs 65%). Stoss therapy is a safe and efficacious treatment option for vitamin D deficiency in children undergoing HSCT and may achieve sufficient levels more rapidly than standard of care.
This trial was registered at www.clinicaltrials.gov as NCT03176849.


Loading Dose of Vitamin D category has the following

199 items in category
see also Overview Loading of vitamin D   Overview Toxicity of vitamin D
Better than Daily 1: Fewer chances to forget, 2) Gets past receptor barrier
Injection category has 62 items
 
It appears that over 1 million Vitamin D loading doses have been taken
Doses ranged from 100,000 to 600,000 IU over a period of a day to a month
No reports of serious adverse reactions
Many studies report on the benefits resulting from loading doses

TOP articles in Loading Dose of Vitamin D

Better than Daily has the following

30 items in BETTER THAN DAILY category

Non-daily (Bolus) is better:

  1. Better compliance for everyone
    • Fewer opportunities to forget.
    • If happen to forget, just take the pill days or weeks later
    • Fewer times to have to take a pill - for those who dislike doing so
  2. Non-daily is better the ~20% who have a poor Vitamin D Receptor
    • A high concentration gradient is one of 14 ways to get past Vitamin D Receptor limitations
    • So, while 80% get no extra benefit from non-daily dosing, 20% will get an extra benefit




Created by admin. Last Modification: Thursday October 28, 2021 06:30:45 GMT-0000 by admin. (Version 10)

Attached files

ID Name Comment Uploaded Size Downloads
15474 Stoss response.jpg admin 21 Apr, 2021 27.15 Kb 930
15473 Stoss 100K to 600K.jpg admin 21 Apr, 2021 23.15 Kb 2865