Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021

---

Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis

Actas Esp Psiquiatr . 2021 Jan;49(1):12-23. Epub 2021 Jan 1.
Ana Lázaro Tomé 1, M José Reig Cebriá 2, Aurora González-Teruel 3, Juan Antonio Carbonell-Asíns 4, Carlos Cañete Nicolás 5, Miguel Hernández-Viadel 5

Trials using infrequent high doses did much better

 Download the PDF from VitaminDWiki

Vitamin D is a fat-soluble vitamin that performs multiple functions in the body. In addition to regulating calcium and phosphate levels in the body and contributing to bone mineralization, it participates in various brain and neurocognitive processes. In fact, the deficiency of this vitamin has also been linked to various psychiatric disorders, including depression.

---

15 Meta-analyses of Depression

This list is automatically updated

---

Depression summary

• Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
• Seasonal Affective Disorder is treated by both bright light and Vitamin D because both make serotonin
• Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
• Omega-3, Magnesium, and St. Johns' Wort also decrease depression
  • Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
  • Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
• Omega-3 and Vitamin D each treat many mental health problems - April 2018
• Antidepressants reduce cellular Vitamin D, increasing fractures, CVD, etc. - Oct 2022
• There are 240 items in the Depression category in VitaminDWiki

---

Better than Daily has the following

Non-daily (Bolus) is virtually always better: -Reasons include:

1. Better compliance
   • Fewer opportunities to forget
   • Fewer times to have to take a pill - for those who dislike it
2. High concentration resulting from infrequent dosing gets past some gene and gut limitations
   • Note: Many studies have found non-daily to be better than daily
     I am unaware of a single study which has found daily to be better than non-daily - Founder of VitaminDWiki Dec 2019

Title change made Sept 2021 caused the visitor count to reset.
There have actually been 1307 visitors to this page since it was originally made