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Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021

Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis

Actas Esp Psiquiatr . 2021 Jan;49(1):12-23. Epub 2021 Jan 1.
Ana Lázaro Tomé 1, M José Reig Cebriá 2, Aurora González-Teruel 3, Juan Antonio Carbonell-Asíns 4, Carlos Cañete Nicolás 5, Miguel Hernández-Viadel 5

Trials using infrequent high doses did much better

 Download the PDF from VitaminDWiki

Vitamin D is a fat-soluble vitamin that performs multiple functions in the body. In addition to regulating calcium and phosphate levels in the body and contributing to bone mineralization, it participates in various brain and neurocognitive processes. In fact, the deficiency of this vitamin has also been linked to various psychiatric disorders, including depression.

18 Meta-analyses of Depression

This list is automatically updated

Depression summary

Some recent publications

Better than Daily has the following

31 items in BETTER THAN DAILY category

Non-daily (Bolus) is better:

  1. Better compliance for everyone
    • Fewer opportunities to forget.
    • If happen to forget, just take the pill days or weeks later
    • Fewer times to have to take a pill - for those who dislike doing so
  2. Non-daily is better the ~20% who have a poor Vitamin D Receptor
    • A high concentration gradient is one of 14 ways to get past Vitamin D Receptor limitations
    • So, while 80% get no extra benefit from non-daily dosing, 20% will get an extra benefit

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Created by admin. Last Modification: Saturday October 8, 2022 21:36:34 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
15495 Depression meta.jpg admin 25 Apr, 2021 29.75 Kb 414
15494 Depression and vitamin D meta.pdf admin 25 Apr, 2021 642.90 Kb 383