Efficacy of vitamin D in the treatment of depression: a systematic review and meta-analysis
Actas Esp Psiquiatr . 2021 Jan;49(1):12-23. Epub 2021 Jan 1.
Ana Lázaro Tomé 1, M José Reig Cebriá 2, Aurora González-Teruel 3, Juan Antonio Carbonell-Asíns 4, Carlos Cañete Nicolás 5, Miguel Hernández-Viadel 5
Trials using infrequent high doses did much better
VitaminDWiki
Meta-analyses of Vitamin D and Depression
- Depression reduced by vitamin D – even ignoring dose size, obesity, and duration – meta-analysis Aug 2022
- Depression is treated by 2,000 IU of Vitamin D (more is better) – meta-analysis July 2022
- Depression treated by 50K IU Vitamin D weekly (but not 1,000 IU daily) – meta-analysis Jan 2021
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Depression less likely if more Vitamin D (12 percent per 10 ng) – meta-analysis July 2019
- Anxiety severity reduced if more than 2 grams of Omega-3 – meta-analysis Sept 2018
- Less depression in seniors taking enough Omega-3 – meta-analysis July 2018
- Unipolar depression treated by Omega-3, Zinc, and probably Vitamin D – meta-analysis Oct 2017
- Depression is associated with low Magnesium – meta-analysis April 2015
- Clinical Trials of vitamin D can have “biological flaws” – Jan 2015
- Slight depression not reduced by adding vitamin D if already had enough (no surprise) – meta-analysis – Nov 2014
- Anti-depression medication about as good as big increase in vitamin D – meta-analysis of flawless data April 2014
- Depression might be reduced by vitamin D – meta-analysis March 2014
- Low vitamin D and depression - Study and meta-analysis, April 2013
- 2X more likely to be depressed if low vitamin D (cohort studies) - Meta-analysis Jan 2013
Depression summary
- Low vitamin D is associated with most types of depression, Including: Seasonal Affective Disorder. manic depression, bipolar disorder, dysthymia, Depression during/after pregnancy, Seniors, Suicide
- Seasonal Affective Disorder is treated by both bright light and Vitamin D because both make serotonin
- Supplementing with Vitamin D (or getting more sun) decreases most types of depression as well as drugs
- Omega-3, Magnesium, and St. Johns' Wort also decrease depression
- Speculate that some combination (Vit D, Omega-3, Mg, St John's) will decrease depression even more
- Note: Both Omega-3 and Magnesium increase the amount of vitamin D which gets to tissues
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- There are
235 items in the Depression category in VitaminDWiki Better than Daily has the following
Non-daily (Bolus) is virtually always better: -Reasons include:
- Better compliance
- Fewer opportunities to forget
- Fewer times to have to take a pill - for those who dislike it
- High concentration resulting from infrequent dosing gets past some gene and gut limitations
- Note: Many studies have found non-daily to be better than daily
I am unaware of a single study which has found daily to be better than non-daily - Founder of VitaminDWiki Dec 2019
- Note: Many studies have found non-daily to be better than daily
Download the PDF from VitaminDWiki
Vitamin D is a fat-soluble vitamin that performs multiple functions in the body. In addition to regulating calcium and phosphate levels in the body and contributing to bone mineralization, it participates in various brain and neurocognitive processes. In fact, the deficiency of this vitamin has also been linked to various psychiatric disorders, including depression.
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