Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial
Journal of Diabetes & Metabolic Disorders, pp 1–9 https://doi.org/10.1007/s40200-019-00416-z
Ali Dadrass Khalid Mohamadzadeh Salamat Email author Kamaladdin Hamidi Kamal Azizbeigi
Lots of Vitamin D benefit is often found when Vitamin D levels get >30 ng
In this study 50,000 IU of vitamin D failed to get >30 ng in 12 weeks
There are 8 ways they could have had more success
Diabetics often have poor gut function
Any of many gut-friendly forms of Vitamin D would likely have had much more benefit
- Vitamin D fails to prevent Type 2 Diabetes (unaware of 8 proven ways) June 2019
- Diabetic inflammation reduced by Calcium and 50,000 IU of vitamin D in 8 weeks – RCT
- Inflammation is reduced by each of the following: Vitamin D, Omega-3, Diet
- How Vitamin D reduces inflammation, improves immunity and fights autoimmunity – review Dec 2018
Overview Diabetes and vitamin D contains the following
- Diabetes is 5X more frequent far from the equator
- Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
- Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
- Sedentary people get less sun / Vitamin D
- Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
- Elderly get 4X less vitamin D from the same amount of sun
Elderly also spend less time outdoors and have more clothes on
- All items in category Diabetes and Vitamin D
511 items: both Type 1 and Type 2
Vitamin D appears to both prevent and treat diabetes
- Appears that >2,000 IU will Prevent
- Appears that >4,000 IU will Treat , but not cure
- Appears that Calcium and Magnesium are needed for both Prevention and Treatment
- which are just some of the vitamin D cofactors
Number of articles in both categories of Diabetes and:
- Dark Skin
24 ; Intervention 55 ; Meta-analysis 36 ; Obesity 32 ; Pregnancy 42 ; T1 (child) 38 ; Omega-3 11 ; Vitamin D Receptor 22 ; Genetics 12 ; Magnesium 25 Click here to see details
Some Diabetes studies
- Diabetes synergistically treated by Vitamin D plus Aerobic exercise – RCT June 2022
- Incidence of Type-2 Diabetes increased 3X in 30 years (by the way, Vitamin D helps) – July 2022
- Vitamin d treats Type II Diabetes in many ways (14 article review) - Sept 2021
- Diabetes 30 percent more likely if poor Vitamin D Receptor – meta-analysis of 47 studies – July 2021
- One vitamin D pill every 4 weeks should cost-effectively reduce diabetes in Iran – Jan 2022
- Most Diabetics getting 40,000 IU of vitamin D weekly did not get to 30 ng (needed gut-friendly form) - RCT June 2020
50 ng of Vitamin D fights Diabetes
- Saudi study defines normal Vitamin D level to be 50 to 70 ng (diabetes, etc.) - June 2020
- Diabetes 5X less likely if more than 50 ng of Vitamin D – April 2018
- T1 Diabetes 3X lower risk if high vitamin D (over 40 ng) – Meta-analysis Nov 2020
- Type 1 Diabetes is prevented and treated by Vitamin D – review of 16 studies – Sept 2019
- Type 1 Diabetes prevention with Vitamin D and Omega-3 – Symposium April 2019
- Prediabetes reduced by weekly 60,000 IU of Vitamin D – RCT Jan 2021
- Prediabetes 1.5 X more likely to go away if take Vitamin D – meta-analysis July 2020
- Magnesium fights diabetes (yet again)– meta-analysis Nov 2021
- Reduced Magnesium is associated with reduced health (Diabetes in this case) - April 2022
- Magnesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes - Jan 2021
Objectives: The present study aimed to investigate the anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency.
Design: This study was a randomized, placebo-controlled, double-blinded clinical trial.
Trial registration code: IRCT20190204042621N1
Forty-eight patients with type 2 diabetes aged 40–65 (from a total of 52 volunteers in Ardabil diabetes clinic) were randomly assigned to either the vitamin D supplementation with resistance training group (VD + RT: n = 12), the resistance training group (RT: n = 12), the vitamin D supplementation group (VD: n = 12), or the control group (CON: n = 12).
The subjects in VD group took vitamin D supplements at 50000 IU per 2 weeks for 3 months; the subjects in RT group exercised 3 times per week for 12 weeks; and the subjects in VD + RT group participated in both treatments. Subjects in CON group were asked to maintain normal daily life pattern for the duration of the study.
Serum Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) and C-reactive protein (CRP) levels were determined at pre and post-test and the data were compared among the four groups and between two tests (4 × 2) using two-way ANOVA with repeated measures.
- IL-6 decreased significantly (P = 0.001) in all groups (
- VD + RT = % -71.73,
- RT = % -65.85,
- VD = % -61.70).
- TNF-α decreased significantly (P = 0.001) in VD + RT (% -44.90) and RT (% -40) groups.
- CRP showed no significant change in any group (P > 0.05).
Results demonstrated that vitamin D supplementation in addition to resistance training had positive effects on some inflammatory markers in T2D and vitamin D deficient men. Vitamin D supplementation was especially effective when it was complemented with exercise training.Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019
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