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Type 2 Diabetes inflammation reduced by 50,000 IU of Vitamin D bi-weekly and resistance training – RCT – June 2019

Anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency: a randomized, double-blinded, placebo-controlled clinical trial

Journal of Diabetes & Metabolic Disorders, pp 1–9 https://doi.org/10.1007/s40200-019-00416-z
Ali Dadrass Khalid Mohamadzadeh Salamat Email author Kamaladdin Hamidi Kamal Azizbeigi

VitaminDWiki

Lots of Vitamin D benefit is often found when Vitamin D levels get >30 ng
In this study 50,000 IU of vitamin D failed to get >30 ng in 12 weeks
There are 8 ways they could have had more success
Diabetics often have poor gut function
Any of many gut-friendly forms of Vitamin D would likely have had much more benefit



Overview Diabetes and vitamin D contains the following

  • Diabetes is 5X more frequent far from the equator
  • Children getting 2,000 IU of vitamin D are 8X less likely to get Type 1 diabetes
  • Obese people get less sun / Vitamin D - and also vitamin D gets lost in fat
  • Sedentary people get less sun / Vitamin D
  • Worldwide Diabetes increase has been concurrent with vitamin D decrease and air conditioning
  • Elderly get 4X less vitamin D from the same amount of sun
        Elderly also spend less time outdoors and have more clothes on
  • All items in category Diabetes and Vitamin D 434 items: both Type 1 and Type 2

Vitamin D appears to both prevent and treat diabetes

  • Appears that >2,000 IU will Prevent
  • Appears that >4,000 IU will Treat , but not cure
  • Appears that Calcium and Magnesium are needed for both Prevention and Treatment
        which are just some of the vitamin D cofactors

 Download the PDF from Sci-Hub via VitaminDWiki

Vitamin D not raised high enough - portion of table in the PDF:

Image

Objectives: The present study aimed to investigate the anti-inflammatory effects of vitamin D and resistance training in men with type 2 diabetes mellitus and vitamin D deficiency.

Design: This study was a randomized, placebo-controlled, double-blinded clinical trial.

Trial registration code: IRCT20190204042621N1

Participants
Forty-eight patients with type 2 diabetes aged 40–65 (from a total of 52 volunteers in Ardabil diabetes clinic) were randomly assigned to either the vitamin D supplementation with resistance training group (VD + RT: n = 12), the resistance training group (RT: n = 12), the vitamin D supplementation group (VD: n = 12), or the control group (CON: n = 12).

Intervention
The subjects in VD group took vitamin D supplements at 50000 IU per 2 weeks for 3 months; the subjects in RT group exercised 3 times per week for 12 weeks; and the subjects in VD + RT group participated in both treatments. Subjects in CON group were asked to maintain normal daily life pattern for the duration of the study.

Measurements
Serum Interleukin-6 (IL-6), Tumor Necrosis Factor-alpha (TNF-α) and C-reactive protein (CRP) levels were determined at pre and post-test and the data were compared among the four groups and between two tests (4 × 2) using two-way ANOVA with repeated measures.

Results

  • IL-6 decreased significantly (P = 0.001) in all groups (
    • VD + RT = % -71.73,
    • RT = % -65.85,
    • VD = % -61.70).
  • TNF-α decreased significantly (P = 0.001) in VD + RT (% -44.90) and RT (% -40) groups.
  • CRP showed no significant change in any group (P > 0.05).

Conclusion
Results demonstrated that vitamin D supplementation in addition to resistance training had positive effects on some inflammatory markers in T2D and vitamin D deficient men. Vitamin D supplementation was especially effective when it was complemented with exercise training.

Created by admin. Last Modification: Monday July 1, 2019 17:15:11 GMT-0000 by admin. (Version 4)

Attached files

ID Name Comment Uploaded Size Downloads
12250 Vit D 50,000 bi-weekly.jpg admin 01 Jul, 2019 16:52 67.77 Kb 114
12249 50,000 2 biweekly diabetes.pdf PDF 2019 admin 01 Jul, 2019 16:52 359.62 Kb 59
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