Loading...
 
Translate Register Log In Login with facebookLogin and Register

Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013

Vitamin D levels in Alzheimer’s and Parkinson’s diseases: A meta-analysis

Nutrition, Volume 29, Issue 6 , Pages 828-832, June 2013
Yan Zhao, B.Sc., Yan Sun, B.Sc., Hong-Fang Ji, Ph.D. jhf at sdut.edu.cn, Liang Shen, Ph.D.email address
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, P. R. China
Received 6 July 2012; accepted 25 November 2012. published online 15 February 2013.

Objective: Recent accumulating evidence shows that vitamin D deficiency is prevalent in individuals with AD and PD.
The purpose of the present study is to perform a meta-analysis on the 25-hydroxyvitamin D (25(OH)D) status in this population of patients.

Methods: We searched all articles in English published up to March 2012 concerning the 25(OH)D level in AD and PD patients.

  • For AD, six studies covering 319 patients and 573 controls were included in the meta-analysis.
  • For PD, five studies discussing 434 patients and 3451 controls were included.

Results: It was found that AD patients had lower levels of 25(OH)D than healthy controls (summary standardized mean difference [SMD], -1.39; 95% confidence interval [CI], -2.79 to 0.01).
Similar results were found for PD patients versus healthy controls (summary SMD, -1.33; 95% CI, -2.44 to -0.21).

Conclusion: The results indicate that despite the similar mean age between patients and healthy controls in each identified study, both AD and PD patients have lower levels of 25(OH)D than controls.

References

  • Cummings JL. Alzheimer's disease. N Engl J Med. 2004;351:56–67
  • Samii A, Nutt JG, Ransom BR. Parkinson's disease. Lancet. 2004;363:1783–1793, Full-Text PDF (149 KB)
  • Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29:125–132
  • Davie CA. A review of Parkinson's disease. Br Med Bull. 2008;86:109–127
  • Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296:2832–2838
  • Knekt P, Laaksonen M, Mattila C, Härkänen T, Marniemi J, Heliövaara M, et al. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 2008;19:666–671
  • Pogge E. Vitamin D and Alzheimer’s disease: Is there a link?. Consult Pharm. 2010;25:440–450
  • Slinin Y, Paudel ML, Taylor BC, Fink HA, Ishani A, Canales MT, et al. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology. 2010;74:33–41
  • Newmark HL, Newmark J. Vitamin D and Parkinson’s disease-a hypothesis. Mov Disord. 2007;22:461–468
  • Evatt ML, DeLong MR, Kumari M, Auinger P, McDermott MP, Tangpricha V, et al. High prevalence of hypovitaminosis D status in patients with early Parkinson disease. Arch Neurol. 2011;68:314–319
  • Evatt ML. Beyond vitamin status: Is there a role for vitamin D in Parkinson disease?. Arch Neurol. 2010;67:795–797
  • Ferrier IN, Leake A, Taylor GA, McKeith IG, Fairbairn AF, Robinson CJ, et al. Reduced gastrointestinal absorption of calcium in dementia. Age Ageing. 1990;19:368–375
  • Sato Y, Asoh T, Oizumi K. High prevalence of vitamin D deficiency and reduced bone mass in elderly women with Alzheimer’s disease. Bone. 1998;23:555–557, Full-Text PDF (81 KB)
  • Sato Y, Kanoko T, Satoh K, Iwamoto J. Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer’s disease. Bone. 2005; 36:61–68, Full-Text PDF (205 KB)
  • Evatt ML, DeLong MR, Khazai N, Rosen A, Triche S, Tangpricha V. Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol. 2008;65:1348–1352
  • Luckhaus C, Mahabadi B, Grass-Kapanke B, Jänner M, Willenberg H, Jäger M, et al. Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer’s disease. J Neural Transm. 2009;116:905–911
  • Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, Qui WQ, et al. 25-hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010;74:18–26
  • Sato Y, Honda Y, Kaji M, Asoh T, Hosokawa K, Kondo I, et al. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson’s disease patients with vitamin D deficiency. Bone. 2002; 31:114–118, Full-Text PDF (73 KB)
  • Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K. Abnormal bone and calcium metabolism in immobilized Parkinson’s disease patients. Mov Disord. 2005;20:1598–1603
  • Abou-Raya S, Helmii M, Abou-Raya A. Bone and mineral metabolism in older adults with Parkinson’s disease. Age Ageing. 2009;38:675–680
  • Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliövaara M. Serum vitamin D and the risk of Parkinson disease. Arch Neurol. 2010;67:808–811
  • Egan KM, Signorello LB, Munro HM, Hargreaves MK, Hollis BW, Blot WJ. Vitamin D insufficiency among African-Americans in the southeastern United States: Implications for cancer disparities (United States). Cancer Cause Control. 2008;19:527–535
  • Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol. 2010;121:297–300
  • Ovesen L, Andersen R, Jakobsen J. Geographical differences in vitamin D status, with particular reference to European countries. Proc Nutr Soc. 2003;62:813–821
  • Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol. 2011;91:115–124
  • Ogunkolade BW, Boucher BJ, Prahl JM, Bustin SA, Burrin JM, Noonan K, et al. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR Genotype in Bangladeshi Asians. Diabetes. 2002;51:2294–2300
  • Michos ED, Reis JP, Post WS, Lutsey PL, Gottesman RF, Mosley TH, et al. 25-Hydroxyvitamin D deficiency is associated with fatal stroke among whites but not blacks: The NHANES-III linked mortality files. Nutrition. 2012;28:367–371, Full-Text PDF (143 KB)
  • Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: Global perspective. Ann Epidemiol. 2009;19:468–483, Full-Text PDF (1288 KB)
  • Nakajima S, Iijima H, Egawa S, Shinzaki S, Kondo J, Inoue T, et al. Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition. 2011; 27:1023–1028, Full-Text PDF (554 KB)
  • Borges MC, Martini LA, Rogero MM. Current perspectives on vitamin D, immune system, and chronic diseases. Nutrition. 2011;27:399–404, Full-Text PDF (288 KB)
  • McKenna MJ, Freaney R. Secondary hyperparathyroidism in the elderly: Means to defining hypovitaminosis D. Osteoporos Int. 1998;8(suppl 2):S3–S6
  • Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011;86:50–60, Full-Text PDF (247 KB)
  • Grant WB. Does vitamin D reduce the risk of dementia?. J Alzheimers Dis. 2009;17:151–159
  • Høyer-Hansen M, Jäättelä M. Autophagy: An emerging target for cancer therapy. Autophagy. 2008;4:574–580
  • Høyer-Hansen M, Nordbrandt SP, Jäättelä M. Autophagy as a basis for the health-promoting effects of vitamin D. Trends Mol Med. 2010;16:295–302
  • von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol. 2010;11:344–349
  • Fisher Y, Nemirovsky A, Baron R, Monsonego A. T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease. PLoS One. 2010;5:e10830
  • Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F. Vitamin D3 and brain development. Neuroscience. 2003;118:641–653
  • Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab. 2002;13:100–105
  • Kalueff AV, Lou YR, Laaksi I, Tuohimaa P. Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport. 2004;15:1271–1274
  • Gezen-Ak D, Dursun E, Ertan T, Hanağasi H, Gürvit H, Emre M, et al. Association between vitamin D receptor gene polymorphism and Alzheimer’s disease. Tohoku J Exp Med. 2007;212:275–282
  • Lehmann DJ, Refsum H, Warden DR, Medway C, Wilcock GK, Smith AD. The vitamin D receptor gene is associated with Alzheimer's disease. Neurosci Lett. 2011;504:79–82
  • Cauley JA, Lacroix AZ, Wu L, Horwitz M, Danielson ME, Bauer DC, et al. Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med. 2008;149:242–250
  • Melton LJ, Beard CM, Kokmen E, Atkinson EJ, O’Fallon WM. Fracture risk in patients with Alzheimer’s disease. J Am Geriatr Soc. 1994;42:614–619
  • Schneider JL, Fink HA, Ewing SK, Ensrud KE, Cummings SR, et al. The association of Parkinson's disease with bone mineral density and fracture in older women. Osteoporos Int. 2008;19:1093–1097

Definition of SMD at Cochrane

See also VitaminDWiki


See any problem with this page? Report it (FINALLY WORKS)