Lymphatic system discovered in brain (what about Multiple Sclerosis, Alzheimer’s, Omega-3 and Vitamin D) – Oct 2017

Scientists Somehow Just Discovered a New System of Vessels in Our Brains Atlantic Oct 2017

“It is unclear what they do—but they likely play a central role in aging and disease."

• “Doctors practicing today have been taught that there are no lymphatic vessels inside the skull.”
• Senior investigator Daniel Reich, who is very interested in Multiple Sclerosis, followed up on the discovery of lymph system in brains (glymphatic system) of mice in 2015
• “In a 2016 study (free PDF), also in mice, glymphatic dysfunction appeared to cause accumulation of Alzheimer-related amyloid proteins.”
• “The flow of glymphatic fluid can change based on a person’s intake of omega-3 fatty acids, a study showed earlier this year.”
  Omega-3 polyunsaturated fatty acids promote amyloid-β clearance from the brain through mediating the function of the glymphatic system (mice) Jan 2017, PDF costs $20
• Long discussion about ALS
• “ALS and Parkinson’s appear to both be fundamentally a result of how tiny vesicles are transported in nerve cells.”

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Human and nonhuman primate meninges harbor lymphatic vessels that can be visualized noninvasively by MRI Oct 2017

Martina Absinta Seung-Kwon Ha Govind Nair Pascal Sati Nicholas J Luciano Maryknoll Palisoc *Antoine Louveau Kareem A Zaghloul Stefania Pittaluga Jonathan Kipnis Daniel S Reich Is a corresponding author expand author list see all

• National Institute of Neurological Disorders and Stroke, National Institutes of Health, United States National Cancer Institute, National Institutes of Health, United States University of Virginia, United States

 Download the PDF from VitaminDWiki

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Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases Sept 2017

• “Brain lymphatic drainage helps maintain water and ion balance of the ISF, waste clearance, and reabsorption of macromolecular solutes.”
• “ A second physiological function includes communication with the immune system modulating immune surveillance and responses of the brain”.
• “The impairment and dysfunction of the brain lymphatic system has crucial roles in age-related changes of brain function and the pathogenesis of neurovascular, neurodegenerative, and neuroinflammatory diseases, as well as brain injury and tumors”

Sections of the $36 PDF

• 2. Key components of the brain lymphatic drainage system
• 3. Physiological functions and regulatory factors of the brain lymphatic drainage system
• 4. Lymphatic drainage pathway-mediated communications between CNS and immune system
• 5. Pathological significance of dysfunction of cerebral lymphatic drainage pathways in neurologic diseases
• 6. Therapeutic or drug delivery strategies targeting key components of CNS lymphatic drainage pathways in neurological diseases

Publisher wants $36 for PDF

VitaminDWiki predicts that the free study published one month later (October) by a different group will become the one quoted, referenced, etc.

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See also VitaminDWiki (related to the brain)

• ALS fought by vitamin D - many studies reduced by Vitamin D and Omega-3
• Overview MS and vitamin D
• Multiple Sclerosis and (lots of) Vitamin D - book by patient on Coimbra protocol - Feb 2016
• 10 Diseases associated with Multiple Sclerosis are also associated with low Omega-3 and vitamin D – Feb 2016
• Overview Stroke and vitamin D reduced by Magnesium and Vitamin D
• ADHD and Vitamin D Deficiency reduced by Magnesium, Omega-3, as well as Vitamin D
• Headache reduced by Magnesium, Omega-3, as well as Vitamin D
• Overview Autism and vitamin D
• One pill every two weeks fights diabetes, cancers, heart failure, and many other diseases
• Omega-3 category in VitaminDWiki
• Magnesium and the Central Nervous System – ebook 2011

	Gets past Brain Blood Barrier	Is in Lymph
Vitamin D	Yes	Yes
Omega-3	Yes	Yes
Magnesium	Yes	?

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Overview Alzheimer's-Cognition and Vitamin D has the following summary

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
• FACT: Dementia is associated with low vitamin D - many studies
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
• OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
• OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  • As of 2018 that combination has worked well with Multiple Sclerosis, Sleep, and Cluster Headaches
  
  There are 12+ Alzheimer’s meta-analyses in VitaminDWiki
  There are 95+ Alzheimer’s studies in VitaminDWiki
• End of Alzheimer's videos, transcripts and many studies
  Dementia is associated with low vitamin D - many studies 50+
  16+ studies in both categories Cognitive and Omega-3
  The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc.
     Customizing the types of treatment to the individual results in reversing Alzheimer's

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Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

366 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (22 studies), Parkinson's (21 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

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Overview Schizophrenia and Vitamin D contains the following summary

14 reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored

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Omega-3 and Cognition (brain) (items in both categories)