Alzheimer's risk 2X less if good diet (and less risk by Omega-3 and or Vitamin D) - Nov 2023

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Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Journal of Alzheimer’s Disease xx (20xx) x-xx DOI 10.3233/JAD-230418
William B. Grant a’ and Steven M. Blake b
a Sunlight, Nutrition, and Health Research Center, San Francisco, CA, USA
b Nutritional Neuroscience, Maui Memory Clinic, Wailuku, HI, USA

Diet is an important nonpharmacological risk-modifying factor for Alzheimer’s disease (AD). The approaches used here to assess diet’s role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational studies, and laboratory studies. Ecological studies have identified fat, meat, and obesity from high-energy diets as important risk factors for AD and reported that AD rates peak about 15-20 years after national dietary changes. Observational studies have compared the Western dietary pattern with those of the Dietary Approaches to Stop Hypertension (DASH), Mediterranean (MedDi), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets.
Those studies identified AD risk factors including

• higher consumption of saturated and total fats,
• meat, and
• ultraprocessed foods

and a lower risk of AD with higher consumption of

• fruits,
• legumes,
• nuts,
• omega-3 fatty acids,
• vegetables, and
• whole grains.

Dietary-induced factors associated with a significant risk of AD include inflammation, insulin resistance, oxidative stress, elevated homocysteine, dietary advanced glycation end products, and trimethylamine A-oxide. The molecular mechanisms by which dietary bioactive components and specific foods affect risk of AD are discussed.

Given most countries’ entrenched food supply systems, the upward trends of AD rates would be hard to reverse.

However, for people willing and able, a low-animal product diet with plenty of anti-inflammatory, low-glycemic load foods may be helpful.
Discussed in Zoom webinar Front Line COVID-19 Critical Care Alliance - Nov 8, 2023
 Download the PDF from VitaminDWiki

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VitaminDWiki – Overview Alzheimer's-Cognition and Vitamin D contains:

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
• FACT: Dementia is associated with low vitamin D - many studies
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
• OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
• OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  • As of 2018 that combination has worked well with Multiple Sclerosis, Sleep, and Cluster Headaches
  
  There are 12+ Alzheimer’s meta-analyses in VitaminDWiki
  There are 95+ Alzheimer’s studies in VitaminDWiki
• End of Alzheimer's videos, transcripts and many studies
  Dementia is associated with low vitamin D - many studies 50+
  16+ studies in both categories Cognitive and Omega-3
  The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc.
     Customizing the types of treatment to the individual results in reversing Alzheimer's

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11+ VitaminDWiki OMEGA-3 pages with ALZHEIMER'S in title

This list is automatically updated

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VitaminDWiki - 49 studies in both categories Omega-3 and Cognitive

This list is automatically updated