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Alzheimer's risk 2X less if good diet (and less risk by Omega-3 and or Vitamin D) - Nov 2023

Diet’s Role in Modifying Risk of Alzheimer’s Disease: History and Present Understanding

Journal of Alzheimer’s Disease xx (20xx) x-xx DOI 10.3233/JAD-230418
William B. Grant a’ and Steven M. Blake b
a Sunlight, Nutrition, and Health Research Center, San Francisco, CA, USA
b Nutritional Neuroscience, Maui Memory Clinic, Wailuku, HI, USA

Diet is an important nonpharmacological risk-modifying factor for Alzheimer’s disease (AD). The approaches used here to assess diet’s role in the risk of AD include multi-country ecological studies, prospective and cross-sectional observational studies, and laboratory studies. Ecological studies have identified fat, meat, and obesity from high-energy diets as important risk factors for AD and reported that AD rates peak about 15-20 years after national dietary changes. Observational studies have compared the Western dietary pattern with those of the Dietary Approaches to Stop Hypertension (DASH), Mediterranean (MedDi), and Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diets.
Those studies identified AD risk factors including

  • higher consumption of saturated and total fats,
  • meat, and
  • ultraprocessed foods

and a lower risk of AD with higher consumption of

  • fruits,
  • legumes,
  • nuts,
  • omega-3 fatty acids,
  • vegetables, and
  • whole grains.

Dietary-induced factors associated with a significant risk of AD include inflammation, insulin resistance, oxidative stress, elevated homocysteine, dietary advanced glycation end products, and trimethylamine A-oxide. The molecular mechanisms by which dietary bioactive components and specific foods affect risk of AD are discussed.

Given most countries’ entrenched food supply systems, the upward trends of AD rates would be hard to reverse.

However, for people willing and able, a low-animal product diet with plenty of anti-inflammatory, low-glycemic load foods may be helpful.
Discussed in Zoom webinar Front Line COVID-19 Critical Care Alliance - Nov 8, 2023
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VitaminDWiki – Overview Alzheimer's-Cognition and Vitamin D contains:

11+ VitaminDWiki OMEGA-3 pages with ALZHEIMER'S in title

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VitaminDWiki - 49 studies in both categories Omega-3 and Cognitive

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Attached files

ID Name Comment Uploaded Size Downloads
20341 Alz risk.png admin 08 Nov, 2023 00:23 120.06 Kb 56
20340 Alz Grant Diet_CompressPdf.pdf PDF 2023 admin 08 Nov, 2023 00:16 276.05 Kb 24