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Long term rat memory aided by optimal level of vitamin D – Dec 2012

Hippocampal long term potentiation in rats under different regimens of vitamin D: an in vivo study.

Neurosci Lett. 2012 Feb 10;509(1):56-9. doi: 10.1016/j.neulet.2011.12.050. Epub 2011 Dec 31.
Salami M, Talaei SA, Davari S, Taghizadeh M.
Physiology Research Center, Kashan University of Medical Sciences, Kashan, Islamic Republic of Iran.

Evidence indicates that vitamin D involves in development of brain as well as its function. This study assesses occurrence of long term potentiation (LTP), as an experimental form of synaptic plasticity, in adult rats under the normal regimen (CON), and the regimens without vitamin D (CON-D) or with a supplement of 1,25(OH)2D3 (CON+D). Stimulating the Schaffer collaterals pre- and post-tetanus excitatory postsynaptic potentials (EPSPs) were recorded in the CA1 area of hippocampus in anesthetized animals. Amplitude change of the EPSPs was considered for comparisons. Our results indicated that the basic EPSPs were similar in the three groups. Tetanization elicited a considerable LTP in both the CON and CON+D rats but a moderate potentiation in the CON-D group. We concluded that optimal level of vitamin D is required for induction of LTP.

Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PMID: 22227619


Wikipedia describes LTP with the phrase cells that fire together wire together

See also VitaminDWiki

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