A few Vitamin D Overviews summaries

Proof that Vitamin D Works has the following summary

+Vitamin D prevents or treats 93 health problems

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Health Problem	Treat Prevent	Reduction by Vit D	RCT = Randomized Controlled Trial * = link to additional RCT CT = Clinical Trial
Hypertension	T P	149 to 142 mm Hg HT risk reduced 10X	*RCT **, 2400 IU. 100,000 IU When Vitamin D > 40 ng
Cardiovascular after attack	T	32 % fewer deaths	CT 1000 IU
Diabetes Type 1	P	85 %	12,000 kids, 2000 IU
Diabetes Type 2	T	62 %	RCT* CRP reduction, 4000 IU Injection is far better - RCT * RCT 50,000 IU/2weeks + probiotics RCT 5,000 IU daily 6 months
Back Pain	T	95 % reduced 50%	5000/10000 IU 60,000 IU weekly
Influenza	P	90 %	RCT *, 2000 IU
Falls	P	50%	RCT, 100,000 IU monthly RCT with Meals on Wheels 2016
Hip Fractures	P	30 %	RCT * 800 IU
Rickets	P	98 %	Turkey, 400 IU NOT RCT, given to all children
Raynaud's Syndrome	T	40 %	RCT, visual scale, 20000 IU Avg
Menstrual pain	P	76 %	RCT, 7000 IU Avg, 70% reduction 2018 PMS reduced by half
Pregnancy risks	P	50 %	RCT, 4000 IU
C-section, unplanned	P	50 %	RCT, 4000 IU, small study
Low birth weight	P	60 %	RCT * 1000 IU of D2
TB	P	60 %	RCT, 800 IU
Breast Cancer	P	60 %	RCT, 1100 IU (2007)
Rheumatoid Arthritis pain	T	40 %	RCT, 500 IU, added to prescription
Cystic Fibrosis	T	75 % 2nd study improved	RCT, pilot 4X fewer deaths 250,000 IU RCT, pilot 8,200 IU
Chronic Kidney	T	90 to 70 PTH	RCT, 3500 IU,
Respiratory Tract Infection	P	63 %	3 RCT, 4000 IU 1 year 2nd 2000/800 IU 20,000 IU weekly
Lupus	T T	zero flares Pain reduced	Loading then 100,000 IU monthly, RCT too RCT 4,000 IU
Sickle Cell	T	Less pain	RCT, up to 100,000 IU/week
Leg ulcer healing	T	4X faster	RCT, 50,0000 IU/week, small study
Traumatic Brain Injury	T	2X	RCT, 20,0000 IU/day with progesterone
Parkinson's Disease	T	Stabilized	RCT, 1200 IU/day
Multiple Sclerosis	P T	68% 95% were CURED	RCT, 7100 IU prevent pre-MS ==> MS 20,000 to 140,000 IU/day
Congestive Heart Failure	T	90 %	RCT, 1000 IU infants (also: Adults, not RCT)
Middle Ear Infection	P	30 %	RCT, 1000 IU infants
Gingivitis	T	88 %	RCT, 2000 IU
Muscle in seniors	T	17 % more muscle	RCT, 4000 IU
Antibiotic use when >70y	T	47 %	RCT, 60,000 IU monthly
Infants taller	Benefit	1 cm tall	RCT, 50,000 IU weekly, for 8 weeks while pregnant
Gestational Diabetes	T	Reduced 3X	RCT, 2 doses of 50,000 IU
After Heart Attack	T	+6% ejection fraction	RCT, 800,000 IU one time
Prostate Cancer	T	Fewer +cores	RCT, 4000 IU (2012)
Asthma	P T	Reduced symptoms	RCT, 60K IU/month; RCT 50K IU/week Need good D at 4 weeks into preg.
Depression	T	Reduced	RCT 300,000 IU injection RCT 1500 IU helped Prozac RCT 50,000 IU weekly, elderly
Low vitamin D while breastfed	P	All infants > 20 mg	RCT, 5,000 IU
Fibromyalgia	T	Half of many still has Fibro	RCT, 30-48 ng RCT 50K IU/week
Hives, Chronic	T	Reduced 40%	RCT, 4000 IU added
Cholesterol	T	Reduced 4 mg	RCT, 400 IU + Ca
Weight Loss	T	lost 5 more lbs	RCT, 2000 IU +diet +exercise
Gestational Diabetes	P	40%	RCT * , 5,000 IU
Chronic Obstructive Pulmonary Disease	T	17X improvement	CT, 50,000 IU weekly RCT 100,000 IU monthly
Asthma	T	1/2 Asthma attacks	RCT >42 mg of vitamin D
Quality of Life (QoL)	T	Nursing Home QoL	CT, 4,000 IU in daily bread
Death of Critically Ill Patients	T	20% increase in survivability	RCT 540 K IU loading than 90K monthly
Restless Leg Syndrome	T	Score 26 ==> 10	CT, Vitamin D dose size not stated in abstract
Hepatitis-C	T	Aided normal drugs	RCT 2.000 IU
Crohn's disease	T	improved when > 30 ng 2nd study fewer relapses	RCT 2,000 IU 10,000 IU RCT
Pre-term birth	P	2.5X decrease, also: fewer c-section & better Apgar	RCT 2,000 IU India
Cluster headaches	T	CH eliminated in 60%	10,000 IU, Mg, Omega-3, etc
Autism	T	80% improved	CT 300 IU/kg/day for 3 months
PreDiabetes	T	~20% reduced	RCT 60,000 IU/month
Weight loss: Overweight and Obese	T	12 lbs in 6 months	RCT 100,000 IU/month
Sarcopenia = muscle loss	T	27% increase	RCT 1,000 IU
Growing Pains	T	60% decrease	~100,000 IU/month -NOT RCT 2nd study, similar results
Osteoarthritis pain	T	60% decrease	50,000 IU/weekly - NOT RCT
ALS	T	helped	2,000 IU - NOT RCT, given to all
Vertigo	T	3X reduction if raised > 10ng	600,000 IU load, then maint. NOT RCT, given to all
Warts	T	80% eliminated injection	NOT RCT 60,000 IU/injection
Metabolic Syndrome	P	reduced 44% when VitD increased by 30 ng	NOT RCT, given to all
Hay fever	P	reduced 48%	RCT 1,000 IU for 30 days
Preeclampsia	P	Recurrance cut in half 3 RCT 3.6 X less likely if > 30 ng	50,000 IU every 2 weeks 4,000 IU daily
Blood cell cancer Multiple Myeloma	T	Survival 90% vs 50%	10,000 IU/week NOT RCT, given to all
Irritable Bowel Syndrome	T	Reduced	3,000 IU spray RCT
Urinary Tract Infection	P	50% reduction	RCT 20,000 IU weekly
Mite Allergy	P	5X reduction	RCT 2,000 IU preg, 800 IU child
Perinatal depression (depression near birth)	T	50% reduction	RCT 2,000 IU for just a few weeks
Vaginosis	T	10X reduction	RCT 2,000 IU
Eczema	T	Reduced	2 RCT 1,600 IU
Non-Alcoholic Fatty Liver Disease	T	Reduced	RCT 20,000 IU weekly
Knee Osteoartiritis	T	Pain Reduced	RCT 60,000 IU monthly after loading dose
Tuberculosis	T	Faster Recovery	RCT single 450,000 IU dose
Stroke - Ischemic	T	Faster Recovery	RCT single 600,000 IU injection RCT single 300,000 IU injection
Sepsis	T	Reduce ICU and Hospital length of stay by 7 days each	RCT 400,000 IU
Trauma deaths	T	50% fewer deaths	Vitamin D & Glutamine NOT RCT, given to all
Hemodialysis patients	T	helped	50,000 IU weekly NOT RCT, given to all
Fatty liver - child	T	2 X reduction	RCT Vitamin D & DHA
Fatigue	T	Reduced	100,000 IU single dose NOT RCT, given to all
Sleep Disorders	T	Nicely treated	RCT 50.000 IU bi-weekly
Pneumonia (Ventilator-associated)	T	RCT Death rate cut in half	300,000 IU injection
Infertile males	T	birth rate doubled	RCT 300,000 IU + maint
Waist size	T	Waist size reduced 3 cm	100,000 IU loading + maint for 6 months for those with Metabolic Syndrome NOT RCT, given to all
Attention Deficient Hyperactivity Disorder	T	Reduced Reduced	RCT 3,000 IU for 12 weeks RCT 50,000 IU weekly
Alcoholic liver cirrhosis	T	improved survival	1,000 IU of vitamin D NOT RCT
Diabetic nephropathy	T	Reduced HOMA-IR, FRS	RCT 50,000 IU weekly
Ulcerative Colitis	T	Reduced 60%	RCT 50,000 IU nano daily for a week
Obese weight loss	T	Lost 3X more pounds	$10 of Vitamin D added to calorie restriction & walking
Endometriosis	T	Nicely treated	RCT 50.000 IU bi-weekly
Diabetic Wounds	T	4X more likely to heal	RCT 6,400 daily
Alzheimer's	T	Often reverse	Each person gets a different amount of Vit D, Omega-3, B12, Iron, etc
Autoimmune	P	Decrease 30%	RCT Vit D + Omega-3
Smoking	T	reduce problems	RCT 50,000 bi-weekly

Diseases which are related due to vitamin D deficiency which contains the following list

+Some of the disease associations: Disease 1 ==> Disease 2 (both associated with low vitamin D

Overview Pregnancy and vitamin D has the following summary

IU	Cumulative Benefit	Blood level	Cofactors	Calcium	*$/month**
200	Better bones for mom with 600 mg of Calcium	6 ng/ml increase	Not needed	No effect	$0.10
400	Less Rickets (but not zero with 400 IU) 3X less adolescent Schizophrenia Fewer child seizures	20-30 ng/ml	Not needed	No effect	$0.20
2000	2X More likely to get pregnant naturally/IVF 2X Fewer dental problems with pregnancy 8X less diabetes 4X fewer C-sections (>37 ng) 4X less preeclampsia (40 ng vs 10 ng) 5X less child asthma 2X fewer language problems age 5	42 ng/ml	Desirable	< 750 mg	$1
4000	2X fewer pregnancy complications 2X fewer pre-term births	49 ng/ml	Should have cofactors	< 750 mg	$3
6000	Probable: larger benefits for above items Just enough D for breastfed infant More maternal and infant weight		Should have cofactors	< 750 mg	$4

Low cost cofactors for vitamin D has the following summary

Cofactor	How Much	Benefit Bone teeth, nails	Comments	Actual supplementation by admin of VitaminDWiki	Cents per day
Calcium	<750mg	Yes	Is excess calcium harmful to health - 2010	*0 = None: get from healthy food**	0 ¢
Magnesium	100mg (element)	Yes	May increase response to Vitamin D by 30% Many other health benefits as well	1/2 teaspoon of Magnesium Chloride ever 3 days Make it by adding hot water to bulk MgCl (1 to 1) also use topically on both knees nightly	~2 ¢
Vitamin K2	>100 ug	Yes	perhaps 100 ug/1000 IU of vitamin D	Super K - all three forms in 1 capsule	20 ¢
Vitamin A	?	maybe	need some, but too much is bad	0*	0
Boron	10 mg	Yes	may increase D3 in blood by 25%	Daily in granola in the morning	1 ¢
Silica	?	Yes		Daily - Horsetail - buy in bulk Include in morning cereal	1 ¢
Omega-3	1 g or 1 Vectomega tablet	By increasing Vitamin D	helps health A LOT May increase active D	1 Vectomega daily - VERY bioavailable	75 ¢
Zinc	?	?	Needed by Vitamin D Receptor Thus results not seen in Vitamin D tests	take 30 mg tablet or liquid weekly	3 ¢
Following are NOT cofactors
Poly fats	Ratio of types of fat	no	Almonds have the best fat ratio and they have Magnesium	daily mixed nuts	5
Water	2.5 liters/quarts	No	Help flush kidneys of any excess Calcium Perhaps only need this much Water if >10,000 IU	>1 quart per day, filtered	0
Iodine	?? micrograms	No	many people are deficient recently I am currently researching the topic	~600 micrograms once a week	~1¢
Sun	How much time varies with skin type, age, latitude, clothing, stand/lie . .	Yes	Probably better than vitamin D supplements	30 minutes sun-nap 80 days/year UVB lamp in the winter	0
Vitamin D	2,000-15,000	Yes	Proven to prevent/treat 76+ diseases	12,000 IU avg - Winter (50,000 every 4 days) 10,000 IU avg - Summer 50,000 every 5 days)	6 5

Overview Sports and vitamin D has the following summary

Athletes are helped by vitamin D by:

Faster reaction time
Far fewer colds/flus during the winter
Less sore/tired after a workout
Fewer micro-cracks and broken bones
Bones which do break heal much more quickly
Increased VO2 and exercise endurance Feb 2011
Indoor athletes especially need vitamin D
Professional indoor athletes are starting to take vitamin D and/or use UV beds
Olympic athletes have used UV/vitamin D since the 1930's
The biggest gain from the use of vitamin D is by those who exercise less than 2 hours per day.
Reduced muscle fatigue with 10,000 IU vitamin D daily
Muscle strength improved when vitamin D added: 3 Meta-analysis
Reduced Concussions
See also: Sports and Vitamin D category 261 items

Overview Alzheimer's-Cognition and Vitamin D has the following summary

FACT: Cognitive decline is 19X more likely if low vitamin D
FACT: Dementia is associated with low vitamin D levels.
FACT: Alzheimer’s 21 % more likely if low vitamin D
FACT: Alzheimer's Disease is 4X less likely if high vitamin D
FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
OBSERVATION: Reports of increased vitamin D levels result in improved cognition
OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
FACT: Vitamin D is extremely low cost and has very very few side effects
CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
- As of 2018 that combination has worked well with
  - Multiple Sclerosis, Sleep, and Cluster Headaches
- Other studies concerning Omega-3 include
All items in category Cognition and vitamin D 334
The End of Alzheimer's - if custom adjust Vitamin D, B-12, Iron, Omega-3, etc.
- Customizing the types of treatment to the individual results in reversing Alzheimer's

Autism treated by Vitamin D: Dr. Cannell - video June 2013 which includes reasons why Dr. Cannell believes Autism is related to Vitamin D (summarized by VitaminDWiki)

Both have strong inheritance features – Vitamin D about 60%
Both have gotten substantially worse in last 30 years
Vitamin D is known to be involved in brain development
All autistic children are VitD deficient, but not all children who are deficient are autistic: genes are involved
When giving vitamin D to cure children of rickets “mental dullness” decreases as well
Children with genes which give them too much (Williams Syndrome) have to reverse of autism – too sociable
Mothers having lots of fish (and thus more vitamin D) give birth to kids with less autistic symptoms
Both associated with weak bones
Both worse around the age of weaning
Autism is more common in rich families – more likely to apply sun screen and stay indoors
Autism increases with drugs which lower levels of vitamin D
Seizures are common with Autism - Vitamin D has been shown to reduce seizures
Fewer autistic symptoms (such as sleep problems) during summer: when child gets more vitamin D from the sun
Both worse with latitude
Both vary with Ultraviolet light
Both vary with time of year (more birth of autistics in March in Northern hemisphere)
2X more urban autism – less UVB in urban environments
Both worse with pollution
Both worse with increased clouds and rain
Both worse with closely spaced pregnancies
Autistics have abnormal immune response – similar to that of vitamin D deficiency
Low levels of vitamin D in mother animals reduces brain function in offspring
Vitamin deficient rat pups have similar brain abnormalities to that of human autistic children
Autistic children get less vitamin D in their blood for the same amount of sun exposure
The 4 males/1 female ratio - Note estrogen increases vitamin D in the brain (testosterone does not)
Both worse in African Americans (A-A 2-3 increased autism rate)
Both worse in Dark-skinned immigrants in Europe

Note: All articles in Autism category 144 items

Multiple Sclerosis and Vitamin D updates from Brazil

Treatment with daily high doses of vitamin D Overcoming MS May 2013
Of course, this is not a cure it's a life-long treatment.. but at least it stops the progression and in many cases even revert back some (sometimes all) of the brain lesions.
Huge page - all in Portuguese about Coimbra's work
Web site of patients who have been cured by Dr. Coimbra Australia 150 ng is the target
Great sequential posts, over a year. by an Australian patient whose MS was reversed by Dr. Coimbra
I Have Multiple Sclerosis: I Am Treating My MS With High Doses Vitamin D experienceproject. May 2013
Gives a fair amount of details, such as taking lots of water and monitoriing for excess Calcium.
Note A home test kit for excess Calcium in the urine is available $10 for 10 tests
Dr. Holick visited with the patients in Brazil Sept 2013

How often might 50,000 IU vitamin D be taken - results of clinical trials

Chart of Vitamin D levels vs disease - Grassroots Health June 2013 has the following chart

derived from Grassroots 2013