Table of contents
- Association of vitamin D receptor gene haplotypes with late-onset Alzheimer's disease in a Southeastern European Caucasian population
- Vitamin D Receptor pages with ALZHEIMER in title (12 as of Aug 2022)
- VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains
- Alzheimer's Disease increased risk with poor genes
- Note: Some diseases, such as COVID and Breast Cancer, actively decrease activation of the VDR
Association of vitamin D receptor gene haplotypes with late-onset Alzheimer's disease in a Southeastern European Caucasian population
Exp Ther Med. 2022 Jul 19;24(3):584 doi: 10.3892/etm.2022.11521
Efthimios Dimitrakis 1 , Martha-Spyridoula Katsarou 1 , Maria Lagiou 1 , Vasiliki Papastefanopoulou 2 , Demetrios A Spandidos 3 , Aristidis Tsatsakis 4 , Socratis Papageorgiou 5 , Paraskevi Moutsatsou 2 , Katerina Antoniou 6 , Christos Kroupis 2 , Nikolaos Drakoulis 1
Note: 4X increase for men
Vitamin D receptor (VDR) gene single nucleotide polymorphisms (SNPs) have been investigated over the past years with the aim of identifying any association with the development of Alzheimer's disease (AD). However, information regarding the potential association of VDR SNP haplotypes with AD is limited. The aim of the present study was to provide additional knowledge on the effects of VDR haplotypes on the development of late-onset AD in a cohort of Southeastern European Caucasians (SECs). The study sample included 78 patients with late-onset AD and 103 healthy subjects as the control group. VDR SNPs that were analyzed were TaqI (rs731236), BsmI (rs1544410) and FokI (rs2228570).
- The CAC (TaqI, BsmI and FokI) haplotype was found to be associated with a 53% lower risk of developing the disease (OR, 0.47; 95% CI, 0.23-0.96; P=0.04) and the
- TAC (TaqI, BsmI and FokI) haplotype was associated with an ~6-fold greater risk of developing AD (OR, 6.19; 95% CI, 1.91-20.13; P=0.0028).
- Female subjects carrying the TAC haplotype had a ~9-fold greater risk of developing AD in comparison to female control subjects (OR, 9.27; 95% CI, 1.86-46.28; P<0.05).
The TaqI and BsmI polymorphisms were in high linkage disequilibrium (D'=0.9717, r=0.8467) and produced a haplotype with a statistically significant different frequency between the control and AD group.
- The TA (TaqI and BsmI) haplotype was associated with an ~8-fold greater risk of developing AD (OR, 8.27; 95% CI, 2.70-25.28; P<0.05).
- Female TA carriers had an ~14-fold greater risk of developing the disease in comparison to female control subjects (OR, 13.93; 95% CI, 2.95-65.87; P<0.05).
On the whole, the present study demonstrates that in the SEC population, TAC and TA are risk haplotypes for AD, while the CAC haplotype may act protectively. SEC women carrying the TAC or TA haplotype are at a greater risk of developing AD, thus suggesting that women are markedly affected by the poor utilization of vitamin D induced by the VDR haplotype.
Download the PDF from VitaminDWiki
Vitamin D Receptor pages with ALZHEIMER in title (12 as of Aug 2022)
This list is automatically updated
VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
- As of 2018 that combination has worked well with Multiple Sclerosis, Sleep, and Cluster Headaches
There are 12+ Alzheimer’s meta-analyses in VitaminDWiki
There are 84+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+
48 studies in both categories Cognitive and Omega-3 see below
The End of Alzheimer's - if custom adjust Vitamin D, B-12, Iron, Omega-3, etc.
Customizing the types of treatment to the individual results in reversing Alzheimer's
Alzheimer's Disease increased risk with poor genes
Alzheimer's genes: Are you at risk? Mayo Clinic
- "Having at least one APOE e4 gene increases your risk of developing Alzheimer's disease two- to threefold. If you have two APOE e4 genes, your risk is even higher, approximately eight- to twelvefold , , , "
Alzheimer disease risk genes: 29 and counting - March 2019 PDF from Sci-Hub
- Note: Neither VDR, Receptor nor Vitamin occur even once in the PDF
Note: Some diseases, such as COVID and Breast Cancer, actively decrease activation of the VDR
I am unaware of any hint that Alzheimer's decreases VDR activation
There may, however, be an increase in Alzheimer's due to Long-COVIDAlzheimer's 9X more likely in women with a poor Vitamin D receptor – Sept 2022
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