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Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018

Vitamin D Improves Neurogenesis and Cognition in a Mouse Model of Alzheimer’s Disease

Mol Neurobiol. 2018; 55(8): 6463–6479. doi: 10.1007/s12035-017-0839-1
François Féron francois.feron at univ-amu.fr, Pascal Millet pascal.millet at univ-amu.fr.
Maria Morello morello at uniroma2.it; Véréna Landel, landel.verena at gmail.com; Emmanuelle Lacassagne, emmanuelle.lacassagne at gmail.com; Kevin Baranger. kevin.baranger at univ-amu.fr, Cedric Annweiler, Cedric.Annweiler at chu-angers.fr


Mice were fed Zero, Normal, and High Vitamin D (HVD = 7,500 IU per kilogram of food)
   Note: Humans eat < 2 kilograms of food per day ==> ~13,000 IU
   Note: Very high dose vitamin D used to cure Multiple Sclerosis uses 20,000 - 140,000 IU daily
   Note: Across many diseases prevention needs only 1/3 to 1/5 of vitamin D needed to treat
     Note: 13,000 IU = 1/4 of 50,000 IU

Improved working memory of all mice if high dose vitamin D given early


Prevented plaque from transgenic mice with high dose vitamin D at 1-6 months 

More brain cells with early high dose

Removed plaque from transgenic mice with high dose vitamin D at 4-9 months

Plaque decreased with high dose later in life

Life Extension Magazine winter edition covered this study

"Vitamin D Removes Amyloid Brain Plaque"
LEF Magazine continues to recommend 50-80 ng level of vitamin D via 5,000 to 8,000 IU

Additional mouse and Vitamin D studies in VitaminDWiki include

Alzheimers-Cognition - Overview starts with

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

254 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search VitaminDWiki for dementia anywhere in text 1190 items Jan 2019
Overview Schizophrenia and Vitamin D
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn

Types of evidence that Vitamin D helps brain problems - 2014


See also web

 Download the PDF from VitaminDWiki

The impairment of hippocampal neurogenesis at the early stages of Alzheimer’s disease (AD) is believed to support early cognitive decline. Converging studies sustain the idea that vitamin D might be linked to the pathophysiology of AD and to hippocampal neurogenesis. Nothing being known about the effects of vitamin D on hippocampal neurogenesis in AD, we assessed them in a mouse model of AD. In a previous study, we observed that dietary vitamin D supplementation in female AD-like mice reduced cognitive decline only when delivered during the symptomatic phase. With these data in hand, we wondered whether the consequences of vitamin D administration on hippocampal neurogenesis are stage-dependent. Male wild-type and transgenic AD-like mice (5XFAD model) were fed with a diet containing either no vitamin D (0VD) or a normal dose of vitamin D (NVD) or a high dose of vitamin D (HVD), from month 1 to month 6 (preventive arm) or from month 4 to month 9 (curative arm). Working memory was assessed using the Y-maze, while amyloid burden, astrocytosis, and neurogenesis were quantified using immunohistochemistry. In parallel, the effects of vitamin D on proliferation and differentiation were assayed on primary cultures of murine neural progenitor cells. Improved working memory and neurogenesis were observed when high vitamin D supplementation was administered during the early phases of the disease, while a normal dose of vitamin D increased neurogenesis during the late phases. Conversely, an early hypovitaminosis D increased the number of amyloid plaques in AD mice while a late hypovitaminosis D impaired neurogenesis in AD and WT mice. The observed in vivo vitamin D-associated increased neurogenesis was partially substantiated by an augmented in vitro proliferation but not an increased differentiation of neural progenitors into neurons. Finally, a sexual dimorphism was observed. Vitamin D supplementation improved the working memory of males and females, when delivered during the pre-symptomatic and symptomatic phases, respectively. Our study establishes that (i) neurogenesis is improved by vitamin D in a male mouse model of AD, in a time-dependent manner, and (ii) cognition is enhanced in a gender-associated way. Additional pre-clinical studies are required to further understand the gender- and time-specific mechanisms of action of vitamin D in AD. This may lead to an adaptation of vitamin D supplementation in relation to patient’s gender and age as well as to the stage of the disease.

Created by admin. Last Modification: Sunday December 2, 2018 15:15:16 GMT-0000 by admin. (Version 19)

Attached files

ID Name Comment Uploaded Size Downloads
10888 Plaque decreased with high dose later in life.jpg admin 23 Nov, 2018 16:47 19.99 Kb 155
10887 More brain cells with early high dose.jpg admin 23 Nov, 2018 16:46 19.75 Kb 153
10886 Memory improved in all mice.jpg admin 23 Nov, 2018 16:46 19.09 Kb 167
10885 Vitamin D Improves Neurogenesis and Cognition.pdf PDF 2018 admin 23 Nov, 2018 12:54 1.46 Mb 51
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