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Brain scans noticed changes in most elderly after COVID infection – March 2022

Covid May Cause Changes in the Brain, New Study Finds NYT March 7

SARS-CoV-2 is associated with changes in brain structure in UK Biobank - Nature March 5

Nature (2022) https://doi.org/10.1038/s41586-022-04569-5
Gwenaëlle Douaud, Soojin Lee, Fidel Alfaro-Almagro, Christoph Arthofer, Chaoyue Wang, Paul McCarthy, Frederik Lange, Jesper L. R. Andersson, Ludovica Griffanti, Eugene Duff, Saad Jbabdi, Bernd Taschler, Peter Keating, Anderson M. Winkler, Rory Collins, Paul M. Matthews, Naomi Allen, Karla L. Miller, Thomas E. Nichols & Stephen M. Smith
Brain scans very different in those who had COVID infection

Task: Quickly draw a line between the circles: 1, A, 2, B, 3, C, 4, D, etc.

Those who were infected completed task much slower

There is strong evidence for brain-related abnormalities in COVID-19 1–13. It remains unknown however whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here, we investigated brain changes in 785 UK Biobank participants (aged 51–81) imaged twice, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans, with 141 days on average separating their diagnosis and second scan, and 384 controls.

The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects. We identified significant longitudinal effects when comparing the two groups, including:

  • (i) greater reduction in grey matter thickness and tissue-contrast in the orbitofrontal cortex and parahippocampal gyrus,
  • (ii) greater changes in markers of tissue damage in regions functionally-connected to the primary olfactory cortex, and
  • (iii) greater reduction in global brain size.

The infected participants also showed on average larger cognitive decline between the two timepoints. Importantly, these imaging and cognitive longitudinal effects were still seen after excluding the 15 cases who had been hospitalised. These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease via olfactory pathways, of neuroinflammatory events, or of the loss of sensory input due to anosmia. Whether this deleterious impact can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow up
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  • Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis - March 2022
    • 22% had cognitive imparement PDF
  • Anticipated Long-Term Cognitive Impairment Following Covid-19 Recovery in Elderly Patients - Feb 2022 PDF
  • Image

VitaminDWiki - both categories Virus and Cognitive

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Brain Plasticity can probably help (computer program, vitamin D, etc.)

VitaminDWiki pages with BRAIN PLASTICITY in title
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Brain changes after COVID revealed by imaging - Nature March 8

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Created by admin. Last Modification: Monday March 14, 2022 15:27:25 GMT-0000 by admin. (Version 21)

Attached files

ID Name Comment Uploaded Size Downloads
17185 d41586-022-00503-x.pdf admin 11 Mar, 2022 126.24 Kb 179
17184 COVID cause.jpg admin 11 Mar, 2022 50.84 Kb 180
17183 anticipated-long-term-cognitive-impairment-following-covid-19-recovery-in-elderly-patients.pdf admin 11 Mar, 2022 710.58 Kb 191
17182 Fatigue and cognitive impairment.pdf admin 11 Mar, 2022 1.52 Mb 172
17181 Trail B lined.jpg admin 10 Mar, 2022 19.70 Kb 178
17180 Trail B.jpg admin 10 Mar, 2022 29.55 Kb 177
17179 COVID FRMI.jpg admin 10 Mar, 2022 122.20 Kb 201
17178 Trail 1A.jpg admin 10 Mar, 2022 15.30 Kb 86
17177 COVID brain change_compressed.pdf admin 10 Mar, 2022 3.46 Mb 262