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Many Neurological Diseases fought by Vitamin D - Dec 2022

Vitamin D in Neurological Diseases

Int. J. Mol. Sci. 2023, 24(1), 87; https://doi.org/10.3390/ijms24010087
by Domenico Plantone 1,*ORCID,Guido Primiano 2,3ORCID,Carlo Manco 1,Sara Locci 1,Serenella Servidei 2,3ORCID andNicola De Stefano 1
1 Centre for Precision and Translational Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy
2 Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
3 Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy

Table of Contents

Vitamin D may have multiple effects on the nervous system and its deficiency can represent a possible risk factor for the development of many neurological diseases. Recent studies are also trying to clarify the different effects of vitamin D supplementation over the course of progressive neurological diseases.
In this narrative review, we summarise vitamin D chemistry, metabolism, mechanisms of action, and the recommended daily intake.
The role of vitamin D on gene transcription and the immune response is also reviewed. Finally, we discuss the scientific evidence that links low 25-hydroxyvitamin D concentrations to the onset and progression of severe neurological diseases, such as

  • multiple sclerosis,
  • Parkinson’s disease,
  • Alzheimer’s disease,
  • migraine,
  • diabetic neuropathy and
  • amyotrophic lateral sclerosis.

Completed and ongoing clinical trials on vitamin D supplementation in neurological diseases are listed.
 Download the PDF from VitaminDWiki

VitaminDWiki – Overview MS and vitamin D contains

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.

VitaminDWiki – Overview Alzheimer's-Cognition and Vitamin D contains:

VitaminDWiki - Overview Parkinson's and Vitamin D contains :

VitaminDWiki – Headache contains

46 Headache pages

Cluster Headache, etc.

21+ VitaminDWiki pages have MIGRAINE in the title
This list is automatically updated

Items found: 21
Title Modified
Cluster and Migraine headache treatment protocol - Sept 2023 29 Sep, 2023
Migraine and Vitamin D 16 Jul, 2023
Migraine risk reduced 30% if have lots of Zinc - Jan 2023 18 Jan, 2023
Migraines have low vitamin D, Migraines plus Restless Leg have far lower vitamin D (no surprise) – Dec 2021 07 Dec, 2021
Migraine Headache association with poor gut – Feb 2020 25 Feb, 2021
Migraine headaches treated by Vitamin D – meta-analysis Jan 2021 16 Jan, 2021
Migraine headaches reduced with 50,000 IU vitamin D weekly – RCT July 2015 14 Jan, 2021
Why Do Multiple Sclerosis and Migraine Coexist – Jan 2020 28 Jan, 2020
Migraines in youths with low Vitamin D wonderfully treated by Vitamin D – June 2019 12 Jul, 2019
Migraines may be due to lack of lack of Magnesium in half of sufferers – May 2012 25 Oct, 2018
Migraine headache 5X less likely if optimal level of vitamin D – Oct 2018 21 Oct, 2018
Migraine headaches cut in half by 4,000 IU of vitamin D – RCT Sept 2018 06 Sep, 2018
Chronic migraine headaches 1.4 X more likely with low vitamin D – July 2018 05 Jul, 2018
Migraines double the risk of strokes (both are associated with low vitamin D) – Jan 2018 01 Feb, 2018
Vitamin D and Migraine – Nov 2010 06 Sep, 2016
Acute Migraine 35 times more likely if low Magnesium levels – May 2016 12 Jun, 2016
Migraine headaches quickly reduced with Magnesium – Meta-analysis Jan 2016 02 Jun, 2016
Childhood migraine in Vitamin D deficient children reduced 6X by addition of daily 5,000 IU and amitriptyline – April 2014 03 Mar, 2015
Migraine in children reduced with vitamin D supplementation – April 2014 10 Apr, 2014
Migraine more common with high vitamin D, perhaps because of low Magnesium – March 2013 04 Aug, 2013
Migraine headaches associated with low vitamin D, 4,000 IU often helps – review Aug 2019 No value for 'modification_date_major'

315 clinical trials of neurological diseases and Vitamin D - Oct 2023

Clinical Trials.gov

VitaminDWiki – Stroke category contains

124 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke

VitaminDWiki – Spinal Cord contains:

20 items in Spinal Cord category

Some of the benefits of adding Vitamin D after Spinal Card Injury

  1. Treats SCI if done quickly (a Vitamin D loading dose seems essential)
  2. People with SCI tend to be Shut-in and get less sunshine
  3. Reduces Pain,Fatigue, Depression
  4. I Helps increase strength
  5. Reduce risk of osteoporosis (very common in SCI)
  6. Reduce risk of pressure ulcers
  7. Reduce risk of. becoming obese
  8. Reduces bone loss resulting from spinal cord injury 2021, FREE PDF

VitaminDWiki – Cerebral Palsy and Vitamin D - many studies CNS needs D by week 3

Fetal Development

VitaminDWiki - ALS fought by vitamin D - many studies

VitaminDWiki – Neuropathy treated by vitamin D - many studies

VitaminDWiki – Brain and Vitamin D - many studies

VitaminDWiki – Down's syndrome and low vitamin D - several studies

Attached files

ID Name Comment Uploaded Size Downloads
20295 Neural.jpg admin 26 Oct, 2023 112.04 Kb 107
20294 ToC Neural.jpg admin 26 Oct, 2023 31.37 Kb 94
20293 Vitamin D in Neurological Diseases_CompressPdf.pdf admin 26 Oct, 2023 363.72 Kb 64