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Mental health intervention trials using enough vitamin D for long enough found benefits – Jan 2017

Vitamin D and mental health in children and adolescents.

Eur Child Adolesc Psychiatry. 2017 Feb 8. doi: 10.1007/s00787-017-0949-3. [Epub ahead of print]
Föcker M1, Antel J2, Ring S2, Hahn D2, Kanal Ö2, Öztürk D2, Hebebrand J2, Libuda L2.

VitaminDWiki
  • They found 10 intervention trials which helped and 11 which did not.
  • All of the 11 trails which did not help are plotted as red Xs on the following chart
  • All of the trials which failed are outside of the green area, which is a guess based on 370+ previous Vitamin D intervention trials for many different health problems

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Vitamin D Wiki files in both of the categories Intervention AND Cognitive

Vitamin D Wiki files in both of the categories Intervention AND Depression

Ckick here for all Vitamin D Wiki files in the category Intervention


PDF is behind a publisher paywall, so VitaminDWiki cannot show it on the web

While vitamin D is known to be relevant for bone health, evidence has recently accumulated for an impact on mental health. To identify the potential benefits and limitations of vitamin D for mental health, an understanding of the physiology of vitamin D, the cut-off values for vitamin D deficiency and the current status of therapeutic trials is paramount. Results of a systematic PUBMED search highlight the association of vitamin D levels and mental health conditions. Here, we focus on children and adolescents studies as well as randomized controlled trials on depression in adults. 41 child and adolescent studies were identified including only 1 randomized controlled and 7 non-controlled supplementation trials. Overall, results from 25 cross-sectional studies as well as from 8 longitudinal studies suggest a role of vitamin D in the pathogenesis of mental disorders in childhood and adolescence. Findings from supplementation trials seem to support this hypothesis. However, randomized controlled trials in adults revealed conflicting results. Randomized controlled trials in childhood and adolescents are urgently needed to support the potential of vitamin D as a complementary therapeutic option in mental disorders. Study designs should consider methodological challenges, e.g., hypovitaminosis D at baseline, appropriate supplementation doses, sufficient intervention periods, an adequate power, clinically validated diagnostic instruments, and homogenous, well-defined risk groups.

PMID: 28176022 DOI: 10.1007/s00787-017-0949-3

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