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Mild cognitive decline reversed by a year of just 800 IU Vitamin D daily – RCT Dec 2020

Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial

Journal of Alzheimer's Disease, vol. 78, no. 4, pp. 1509-1518, 2020 DOI 10.3233/JAD-200926
Tong Yanga,b, Hualou Wanga,b, Ying Xiongc, Chong Chend,e,f,g, Keran Duanh, Jingya Jiaa,b and Fei Maa,b,

Cognitive parameters having high probability of improvement (p<0.001)


Most previous studies have found that larger increases in Vitamin D levels were needed.
Why did the brain showed so many improvements with such a low dose?
   More Magnesium?
   Get across brain barrier better for some reason?

Cognitive intervention trials with Vitamin D:

A potential way of getting more Vitamin D into the brain

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

293 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search VitaminDWiki for dementia anywhere in text 1190 items Jan 2019
Overview Schizophrenia and Vitamin D
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn

Types of evidence that Vitamin D helps brain problems - 2014

 Download the PDF from VitaminDWiki
Vitamin D levels in blood were raised only a small amount

Background: Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial.

Objective: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress.

Methods: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months.

Results: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p < 0.001). Leukocyte TL was significantly higher, while serum 8 - O XO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p < 0.001). According to mixed-model repeated-measures ANOVA analysis, vitamin D group showed a significant enhancement in the FSIQ score for 12 months compared with the control (estimate value = 5.132, p < 0.001).

Conclusion: Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.

Created by admin. Last Modification: Friday January 8, 2021 13:29:15 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
14827 800 IU not raise levels much.jpg admin 08 Jan, 2021 13:05 39.71 Kb 27
14826 Cognition 800 IU.jpg admin 08 Jan, 2021 13:05 62.01 Kb 29
14825 improved cognition sci-hub.pdf PDF 2020 admin 08 Jan, 2021 13:04 157.39 Kb 10
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