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Mild cognitive decline reversed by a year of just 800 IU Vitamin D daily – RCT Dec 2020

Vitamin D Supplementation Improves Cognitive Function Through Reducing Oxidative Stress Regulated by Telomere Length in Older Adults with Mild Cognitive Impairment: A 12-Month Randomized Controlled Trial

Journal of Alzheimer's Disease, vol. 78, no. 4, pp. 1509-1518, 2020 DOI 10.3233/JAD-200926
Tong Yanga,b, Hualou Wanga,b, Ying Xiongc, Chong Chend,e,f,g, Keran Duanh, Jingya Jiaa,b and Fei Maa,b,

Cognitive parameters having high probability of improvement (p<0.001)


Most previous studies have found that larger increases in Vitamin D levels were needed.
Why did the brain showed so many improvements with such a low dose?
   More Magnesium?
   Get across brain barrier better for some reason?

Cognitive intervention trials with Vitamin D:

A potential way of getting more Vitamin D into the brain

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

375 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (23 studies), Parkinson's (22 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

 Download the PDF from VitaminDWiki
Vitamin D levels in blood were raised only a small amount

Background: Cognitive decline in older adults is a serious public health problem today. Association between vitamin D supplementation and cognition remains controversial.

Objective: To determine whether a 12-month vitamin D supplementation improves cognitive function in elderly subjects with mild cognitive impairment (MCI), and whether it is mediated through the mechanism in which telomere length (TL) regulate oxidative stress.

Methods: This was a double-blind, randomized, placebo-controlled trial in Tianjin, China. Participants were all native Chinese speakers aged 65 years and older with MCI. 183 subjects were randomized to an intervention group (vitamin D 800 IU/day, n = 93) or a placebo group (the matching starch granules, n = 90), and followed up for 12 months. Tests of cognitive function and mechanism-related biomarkers were evaluated at baseline, 6 months, and 12 months.

Results: Repeated-measures ANOVA showed substantial improvements in the full scale intelligence quotient (FSIQ), information, digit span, vocabulary, block design, and picture arrangement scores in the vitamin D group over the placebo group (p < 0.001). Leukocyte TL was significantly higher, while serum 8 - O XO-dG, OGG1mRNA, and P16INK4amRNA revealed greater decreases in the vitamin D group over the placebo group (p < 0.001). According to mixed-model repeated-measures ANOVA analysis, vitamin D group showed a significant enhancement in the FSIQ score for 12 months compared with the control (estimate value = 5.132, p < 0.001).

Conclusion: Vitamin D supplementation for 12 months appears to improve cognitive function through reducing oxidative stress regulated by increased TL in order adults with MCI. Vitamin D may be a promising public health strategy to prevent cognitive decline.

Created by admin. Last Modification: Friday January 8, 2021 13:29:15 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
14827 800 IU not raise levels much.jpg admin 08 Jan, 2021 39.71 Kb 316
14826 Cognition 800 IU.jpg admin 08 Jan, 2021 62.01 Kb 492
14825 improved cognition sci-hub.pdf admin 08 Jan, 2021 157.39 Kb 332