Ann Nutr Metab 2014;65:81-89, (DOI:10.1159/000365154)
Andreeva V.A. v.andreeva at eren.smbh.univ-paris13.fr
· Whegang-Youdom S. · Touvier M. · Assmann K.E. · Fezeu L. · Hercberg S. · Galan P. · Kesse-Guyot E.
aSorbonne Paris Cité, Equipe de Recherche en Epidémiologie Nutritionnelle, Centre d'Epidémiologie et Biostatistiques Paris Nord, Inserm U1153, Inra U1125, Cnam, Université Paris 13, Université Paris 5, Université Paris 7, and bDépartement de Santé Publique, Hôpital Avicenne, Bobigny, France
Background/Aims: We evaluated the cross-time association between midlife dietary vitamin D intake and subsequent cognitive performance in a French general-population sample. Methods: Data from participants in both the SU.VI.MAX trial (1994-2002) and the SU.VI.MAX 2 observational study (2007-2009) were used. Dietary intake was estimated at baseline from 6 or more 24-hour records. Cognitive performance was evaluated 13 years later with a comprehensive neuropsychological battery. Parameter estimates of cognitive performance according to quartiles (Q) of vitamin D intake were estimated via ANCOVA.
Results: In a sample of 1,990 aging adults, principal component analyses yielded two cognitive factors - for episodic/semantic memory and short-term memory/executive function; however, neither one displayed associations with dietary vitamin D intake. Midlife vitamin D intake was significantly and positively associated with scores on the forward digit span task measuring short-term memory (fully adjusted model: mean difference, Q4 vs. Q1 = 1.95; 95% CI 0.37-3.53; ptrend = 0.03). No significant interaction with either sex or lifetime sun exposure was found.
Conclusions: Midlife vitamin D intake exhibited a cross-time and domain-specific association with cognition in the context of aging. Further investigations in this area of prevention are warranted given the rapidly expanding elderly population and the absence of curative treatment for dementia.
© 2014 S. Karger AG, Basel
- Cognition and vitamin D – summary of expert opinions – July 2014
- Cognition declined somewhat if low vitamin D – March 2014
- Dementia 13X more likely in elderly with low vitamin D – May 2014
- Vitamin D was one of the few drugs which improved cognition in seniors – Aug 2013
- Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012
- "Senior moment" 25X more likely with low vitamin D - Feb 2012
- Visual memory improved a bit by vitamin D if start with less than 30 ng – RCT Jan 2017
- Senior cognition improved somewhat by 4,000 IU of Vitamin D (if initially less than 30 ng) – RCT April 2017
- Better memory if take lots of vitamin D (senior rats) – May 2015
- Slower cognitive decline if higher vitamin D (1500 adults, 5 years) – Feb 2018
- Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
- Short-term memory 2X better for those who took slightly more vitamin D 14 years before – Sept 2014
Overview Alzheimer's-Cognition and Vitamin D has the following summary
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
- As of 2018 that combination has worked well with Multiple Sclerosis, Sleep, and Cluster Headaches
There are 12+ Alzheimer’s meta-analyses in VitaminDWiki
There are 95+ Alzheimer’s studies in VitaminDWiki
- End of Alzheimer's videos, transcripts and many studies
Dementia is associated with low vitamin D - many studies 50+
16+ studies in both categories Cognitive and Omega-3
The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc.
Customizing the types of treatment to the individual results in reversing Alzheimer's