Low Serum Vitamin D Status Is Associated with Incident Alzheimer’s Dementia in the Oldest Old
Nutrients 2023, 15(1), 61; https://doi.org/10.3390/nu15010061
by Debora Melo van Lent 1,2,*ORCID,Sarah Egert 3,Steffen Wolfsgruber 1,4,Luca Kleineidam 4,Leonie Weinhold 5,Holger Wagner-Thelen 4,6,Birgit Stoffel-Wagner 7,Horst Bickel 8,Birgitt Wiese 9,Siegfried Weyerer 10,Michael Pentzek 11,Frank Jessen 1,6,Matthias Schmid 1,5,Wolfgang Maier 4,Martin Scherer 12,Steffi G. Riedel-Heller 13,†,Alfredo Ramirez 1,4,6,†ORCID andMichael Wagner 1,4,†ORCID
Background. Vitamins A, D and E and beta-carotene may have a protective function for cognitive health, due to their antioxidant capacities.
Methods. We analyzed data from 1334 non-demented participants (mean age 84 years) from the AgeCoDe study, a prospective multicenter-cohort of elderly general-practitioner patients in Germany, of whom n = 250 developed all-cause dementia and n = 209 developed Alzheimer’s dementia (AD) during 7 years of follow-up. We examined whether concentrations of vitamins A (retinol), D (25-hydroxycholecalciferol) and E (alpha-tocopherol) and beta-carotene, would be associated with incident (AD) dementia.
Results. In our sample, 33.7% had optimum vitamin D concentrations (≥50 nmol/L). Higher concentrations of vitamin D were associated with lower incidence of all-cause dementia and AD (HR 0.99 (95%CI 0.98; 0.99); HR0.99 (95%CI 0.98; 0.99), respectively).
In particular, subjects with vitamin D deficiency (25.3%, <25 nmol/L) were at increased risk for all-cause dementia and AD (HR1.91 (95%CI 1.30; 2.81); HR 2.28 (95%CI 1.47; 3.53), respectively). Vitamins A and E and beta-carotene were unrelated to (AD) dementia.
Conclusions. Vitamin D deficiency increased the risk to develop (AD) dementia. Our study supports the advice for monitoring vitamin D status in the elderly and vitamin D supplementation in those with vitamin D deficiency. We observed no relationships between the other vitamins with incident (AD) dementia, which is in line with previous observational studies.
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VitaminDwiki - Overview Alzheimer's-Cognition and Vitamin D contains
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: [https://www.alz.org/alzheimers-dementia/what-is-alzheimers/causes-and-risk-factors/genetics|<1% of Alzheimers is due to poor genetics]
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
- As of 2018 that combination has worked well with Multiple Sclerosis, Sleep, and Cluster Headaches
There are 12+ Alzheimer’s meta-analyses in VitaminDWiki
There are 84+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+
48 studies in both categories Cognitive and Omega-3 see below
The End of Alzheimer's - if custom adjust Vitamin D, B-12, Iron, Omega-3, etc.
Customizing the types of treatment to the individual results in reversing Alzheimer'sAlzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
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