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Cognition improved a tiny amount with 400 IU of vitamin D (not a surprise) – RCT Oct 2018

Effects of vitamin D3 supplementation on cognition and blood lipids: a 12-month randomised, double-blind, placebo-controlled trial

Journal of Neurol Neurosurg Psychiatry http://dx.doi.org/10.1136/jnnp-2018-318594
Jing Hu1, Jingya Jia1, Yanping Zhang2, Rujuan Miao1, Xiaoxu Huo1, Fei Ma1


With 400 IU for a year Vitamin D Levels 19.07 ng ==> 19.77 ng
Note: Vitamin D levels generally need to be > 30 ng to make a difference

Items of Cognition and Intervention (give Vitamin D and see what happens)

Items of Cognition and Meta-analysis

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

370 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (23 studies), Parkinson's (22 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014

PDF is available free at Sci-Hub  10.1136/jnnp-2018-318594

Alzheimer’s disease (AD) is the leading cause of dementia and loss of autonomy and independency in the elderly.1 Currently, no effective pharmacological interventions change the onset or progression of AD.2 Mild cognitive impairment (MCI) is possibly the earliest stage of detectable dementia and may be the optimal time to intervene.3 4 Exploring factors and biochemical markers that are associated with late-life dementia has attracted much attention. A growing body of epidemiological evidence has suggested that deficiency of nutrition components may be related to the development of cognitive decline.5

Vitamin D can play an important role in brain health and function, and exert various neuroprotective effects in brain areas essential for cognition.6 Being severely deficient in vitamin D is associated with a more than twofold increased risk of developing dementia.7 Protective effects of vitamin D on cognition and pathology are also concluded in animal models.8 9Sonnenberg et al 9 found that 1,25-dihydroxyvitamin D (1,25-D) treatment increases choline acetyltransferase activity in specific rat brain nuclei. Supplementation of vitamin D3 may have contributed to the observed improvements to memory via increasing acetylcholine concentration. Vitamin D research has gained increased attention in recent times due to its roles beyond bone health and calcium homeostasis, such as neurocognitive.10 However, results have been inconclusive.1 11 The mechanisms still remain unclear.

The brain is the most lipid-rich organ in the body,12 and almost all major classes of lipids have some correlation with AD pathogenesis.13 Several population-based studies reported that elderly people with AD or with dementia or cognitive impairment have higher plasma total cholesterol (TC) than sex and age-matched non-demented peers.14–16 Brain and peripheral lipid levels were once thought to be entirely isolated from one another by the blood–brain barrier, but recent evidence …

Created by admin. Last Modification: Tuesday October 23, 2018 01:31:32 GMT-0000 by admin. (Version 4)