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Calcitriol (activated Vitamin D) increases dementia (however, regular D decreases it) – June 2022


Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies

Aging Cell. 2022;00:e13670. https://doi.org/10.1111/acel.13670
Rai-Hua Lai1 | Chih-Cheng Hsu2’3’4’5 | Ben-Hui Yu3 | Yu-Ru Lo3 | Yueh-Ying Hsu1 | Mei-Hsin Chen1 | Jyh-Lyh Juang1’6 juang at nhri.edu.tw
1institute of Molecular and Genomic Medicine, National Health Research institutes, Miaoli, Taiwan
2National Center for Geriatrics and Welfare Research, National Health Research institutes, Miaoli, Taiwan
3institute of Population Health Sciences, National Health Research institutes, Miaoli, Taiwan
4Department of Health Services Administration, China Medical University, Taichung, Taiwan
5Department of Family Medicine, MinSheng General Hospital, Taoyuan, Taiwan
6Ph.D. Program for Aging, China Medical University, Taichung, Taiwan

More Calcitriol ==> More dementia

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More Calcitriol ==> More mortality

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Vitamin D deficiency has been epidemiologically linked to Alzheimer's disease (AD) and other dementias, but no interventional studies have proved causality. Our previous work revealed that the genomic vitamin D receptor (VDR) is already converted into a non-genomic signaling pathway by forming a complex with p53 in the AD brain. Here, we extend our previous work to assess whether it is beneficial to supplement AD mice and humans with vitamin D. Intriguingly, we first observed that APP/PS1 mice fed a vitamin D-sufficient diet showed significantly lower levels of serum vitamin D, suggesting its deficiency may be a consequence not a cause of AD. Moreover, supplementation of vitamin D led to increased Ap deposition and exacerbated AD. Mechanistically, vitamin D supplementation did not rescue the genomic VDR/RXR complex but instead enhanced the non-genomic VDR/p53 complex in AD brains.
Consistently, our population-based longitudinal study also showed that dementiafree older adults (n = 14,648) taking vitamin D3 supplements for over 146 days/year were 1.8 times more likely to develop dementia than those not taking the supplements. Among those with pre-existing dementia (n = 980), those taking vitamin D3 supplements for over 146 days/year had 2.17 times the risk of mortality than those not taking the supplements. Collectively, these animal model and human cohort studies caution against prolonged use of vitamin D by AD patients.
 Download the PDF from VitaminDWiki


Note: Calcitriol is normally prescribed for Kidney problems and some Cancers


VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains


VitaminDWiki - Calcitriol category contains

56 Calcitriol items in VitaminDWiki     See also: Calcidiol category listing which has 46 items

Many ways to increase Vitamin D - click on chart for details
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Major flaws in 2022 rumor that vitaminD worsens Alzheimer's dementia: Nothing was done correctly in this study

Dr Alex Kennerly Vasquez


Created by admin. Last Modification: Thursday September 1, 2022 23:31:37 GMT-0000 by admin. (Version 8)

Attached files

ID Name Comment Uploaded Size Downloads
18095 More Calcitriol, more mortality.jpg admin 13 Jul, 2022 33.39 Kb 348
18094 Calcitriol and dementia.jpg admin 13 Jul, 2022 35.06 Kb 380
18093 Calcitriol and dementia.pdf admin 13 Jul, 2022 518.49 Kb 123