Calcitriol (activated Vitamin D) increases dementia (however, regular D decreases it) – June 2022

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Vitamin D supplementation worsens Alzheimer's progression: Animal model and human cohort studies

Aging Cell. 2022;00:e13670. https://doi.org/10.1111/acel.13670
Rai-Hua Lai1 | Chih-Cheng Hsu2’3’4’5 | Ben-Hui Yu3 | Yu-Ru Lo3 | Yueh-Ying Hsu1 | Mei-Hsin Chen1 | Jyh-Lyh Juang1’6 juang at nhri.edu.tw
1institute of Molecular and Genomic Medicine, National Health Research institutes, Miaoli, Taiwan
2National Center for Geriatrics and Welfare Research, National Health Research institutes, Miaoli, Taiwan
3institute of Population Health Sciences, National Health Research institutes, Miaoli, Taiwan
4Department of Health Services Administration, China Medical University, Taichung, Taiwan
5Department of Family Medicine, MinSheng General Hospital, Taoyuan, Taiwan
6Ph.D. Program for Aging, China Medical University, Taichung, Taiwan

More Calcitriol ==> More dementia

More Calcitriol ==> More mortality

Vitamin D deficiency has been epidemiologically linked to Alzheimer's disease (AD) and other dementias, but no interventional studies have proved causality. Our previous work revealed that the genomic vitamin D receptor (VDR) is already converted into a non-genomic signaling pathway by forming a complex with p53 in the AD brain. Here, we extend our previous work to assess whether it is beneficial to supplement AD mice and humans with vitamin D. Intriguingly, we first observed that APP/PS1 mice fed a vitamin D-sufficient diet showed significantly lower levels of serum vitamin D, suggesting its deficiency may be a consequence not a cause of AD. Moreover, supplementation of vitamin D led to increased Ap deposition and exacerbated AD. Mechanistically, vitamin D supplementation did not rescue the genomic VDR/RXR complex but instead enhanced the non-genomic VDR/p53 complex in AD brains.
Consistently, our population-based longitudinal study also showed that dementiafree older adults (n = 14,648) taking vitamin D3 supplements for over 146 days/year were 1.8 times more likely to develop dementia than those not taking the supplements. Among those with pre-existing dementia (n = 980), those taking vitamin D3 supplements for over 146 days/year had 2.17 times the risk of mortality than those not taking the supplements. Collectively, these animal model and human cohort studies caution against prolonged use of vitamin D by AD patients.
 Download the PDF from VitaminDWiki

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Note: Calcitriol is normally prescribed for Kidney problems and some Cancers

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VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D contains

• FACT: Cognitive decline is 19X more likely if low vitamin D
• FACT: Dementia is associated with low vitamin D levels.
• FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
• FACT: Dementia is associated with low vitamin D - many studies
• FACT: Alzheimer's Disease is 4X less likely if high vitamin D
• FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
• FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
• OBSERVATION: Reports of increased vitamin D levels result in improved cognition
• OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
• OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
• OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
• OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
• OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
• OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
• OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
• OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
• OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
• OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
• FACT: Vitamin D is extremely low cost and has very very few side effects
• CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
• PREDICTION: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
  • As of 2018 that combination has worked well with Multiple Sclerosis, Sleep, and Cluster Headaches
  
  There are 12+ Alzheimer’s meta-analyses in VitaminDWiki
  There are 84+ Alzheimer’s studies in VitaminDWiki
  Dementia is associated with low vitamin D - many studies 50+
  48 studies in both categories Cognitive and Omega-3 see below
  The End of Alzheimer's - if custom adjust Vitamin D, B-12, Iron, Omega-3, etc.
     Customizing the types of treatment to the individual results in reversing Alzheimer's

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VitaminDWiki - Calcitriol category contains

56 Calcitriol items in VitaminDWiki     See also: Calcidiol category listing which has 42 items

Many ways to increase Vitamin D - click on chart for details

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Major flaws in 2022 rumor that vitaminD worsens Alzheimer's dementia: Nothing was done correctly in this study

Dr Alex Kennerly Vasquez