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Alzheimer's risk increased 7 percent for every 4 ng decrease in Vitamin D– meta-analysis Nov 2018

25-Hydroxyvitamin D Levels and the Risk of Dementia and Alzheimer's Disease: A Dose-Response Meta-Analysis.

Front Aging Neurosci. 2018 Nov 9;10:368. doi: 10.3389/fnagi.2018.00368. eCollection 2018.
Chen H1, Xue W1, Li J1, Fu K1, Shi H2, Zhang B3, Teng W1, Tian L4.
1 Deparment of Neurology, The First Affiliated Hospital, China Medical University, Shenyang, China.
2 Clinical Department one, China Medical University, Shenyang, China.
3 Department of Endodontics, School of Stomatology, China Medical University, Shenyang, China.
4 Department of Geriatrics, Shengjing Hospital, China Medical University, Shenyang, China.
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Background and Purpose: Conclusions of previous cohort studies on the relationship between 25-hydroxyvitamin D level and the risk of dementia and Alzheimer's disease were not consistent. Thus, we performed a dose-response meta-analysis to evaluate this relationship by summarizing cohort studies.

Methods: Pubmed, Embase, Cochrane, and Web of Science databases were searched for relevant studies. Cohort studies concerning the association between 25-hydroxyvitamin D level and dementia or Alzheimer's disease were included. Results of studies were pooled and the dose-response relationship was determined using a random-effect model.

Results: Ten cohort studies, with 28,640 participants were included. A significant inverse relationship was found between 25-hydroxyvitamin D level and the risk of dementia and Alzheimer's disease. In addition, we found a linear dose-response relationship in that a 10 nmol/L increase in 25-hydroxyvitamin D level may lead to a 5% decrease in the risk of dementia (relative risk, 0.95; 95% confidence interval, 0.93-0.98) and 7% in the risk of Alzheimer's disease (relative risk, 0.93; 95% confidence interval, 0.89-0.97).

Conclusion: Plasma or serum 25-hydroxyvitamin D concentration was inversely related to the risk of dementia and Alzheimer's disease, consistent with a linear dose-response relationship.


Created by admin. Last Modification: Tuesday November 27, 2018 13:16:28 GMT-0000 by admin. (Version 6)

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10924 Alz forest plot.jpg admin 27 Nov, 2018 28.18 Kb 623
10923 Alz chart.jpg admin 27 Nov, 2018 15.84 Kb 646
10922 Cognition meta Nov 2018.pdf admin 27 Nov, 2018 1.32 Mb 567