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Many Neurological Diseases fought by Vitamin D - Dec 2022


Vitamin D in Neurological Diseases

Int. J. Mol. Sci. 2023, 24(1), 87; https://doi.org/10.3390/ijms24010087
by Domenico Plantone 1,*ORCID,Guido Primiano 2,3ORCID,Carlo Manco 1,Sara Locci 1,Serenella Servidei 2,3ORCID andNicola De Stefano 1
1 Centre for Precision and Translational Medicine, Department of Medicine, Surgery and Neuroscience, University of Siena, 53100 Siena, Italy
2 Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
3 Dipartimento Universitario di Neuroscienze, Università Cattolica del Sacro Cuore, 00168 Rome, Italy

Table of Contents
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Vitamin D may have multiple effects on the nervous system and its deficiency can represent a possible risk factor for the development of many neurological diseases. Recent studies are also trying to clarify the different effects of vitamin D supplementation over the course of progressive neurological diseases.
In this narrative review, we summarise vitamin D chemistry, metabolism, mechanisms of action, and the recommended daily intake.
The role of vitamin D on gene transcription and the immune response is also reviewed. Finally, we discuss the scientific evidence that links low 25-hydroxyvitamin D concentrations to the onset and progression of severe neurological diseases, such as

  • multiple sclerosis,
  • Parkinson’s disease,
  • Alzheimer’s disease,
  • migraine,
  • diabetic neuropathy and
  • amyotrophic lateral sclerosis.

Completed and ongoing clinical trials on vitamin D supplementation in neurological diseases are listed.
 Download the PDF from VitaminDWiki


VitaminDWiki – Overview MS and vitamin D contains

Clinical interventions have shown that Vitamin D can prevent, treat, and even cure Multiple Sclerosis, at a tiny fraction of the cost of the drugs now used to treat it, and without side effects.

Summary: lack of consensus on how much to prevent, treat, or cure MS.


VitaminDWiki – Overview Alzheimer's-Cognition and Vitamin D contains:


VitaminDWiki - Overview Parkinson's and Vitamin D contains :


VitaminDWiki – Headache contains

46 Headache pages

Cluster Headache, etc.

21+ VitaminDWiki pages have MIGRAINE in the title
This list is automatically updated


315 clinical trials of neurological diseases and Vitamin D - Oct 2023

Clinical Trials.gov


VitaminDWiki – Stroke category contains

124 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D  Overview Cardiovascular and vitamin D

Stroke more likely if low Vitamin D

Post-Stroke worse if low Vitamin D

Post-Stroke better if add Vitamin D

Post-Stroke better if Vitamin D actually gets to cells

9 studies in both categories Depression and Stroke

VitaminDWiki – Spinal Cord contains:

20 items in Spinal Cord category

Some of the benefits of adding Vitamin D after Spinal Card Injury

  1. Treats SCI if done quickly (a Vitamin D loading dose seems essential)
  2. People with SCI tend to be Shut-in and get less sunshine
  3. Reduces Pain,Fatigue, Depression
  4. I Helps increase strength
  5. Reduce risk of osteoporosis (very common in SCI)
  6. Reduce risk of pressure ulcers
  7. Reduce risk of. becoming obese
  8. Reduces bone loss resulting from spinal cord injury 2021, FREE PDF

VitaminDWiki – Cerebral Palsy and Vitamin D - many studies CNS needs D by week 3

Fetal Development


VitaminDWiki - ALS fought by vitamin D - many studies


VitaminDWiki – Neuropathy treated by vitamin D - many studies


VitaminDWiki – Brain and Vitamin D - many studies


VitaminDWiki – Down's syndrome and low vitamin D - several studies

Attached files

ID Name Comment Uploaded Size Downloads
20295 Neural.jpg admin 26 Oct, 2023 112.04 Kb 107
20294 ToC Neural.jpg admin 26 Oct, 2023 31.37 Kb 94
20293 Vitamin D in Neurological Diseases_CompressPdf.pdf admin 26 Oct, 2023 363.72 Kb 64