- From MDEdge
- Vitamin D inhaled thru the nose gets some directly to the brain
- Vitamin D prevents/treats Multiple Sclerosis and 10 other brain disorders
- VitaminDWiki – Alzheimer's-Cognition
- VitaminDWiki – Stroke category has
131 items - VitaminDWiki – Autism category has
163 items - VitaminDWiki – Parkinson's category has
117 items - VitaminDWiki - Attention Deficit Hyperactivity Disorder
- VitaminDWiki - Amyotrophic Lateral Sclerosis- 27+ items
- VitaminDWiki - Bipolar Disorder
16 items - VitaminDWiki - Brain - 98 items
- VitaminDWiki – Depression category has
268 items - VitaminDWiki – Multiple Sclerosis category has
412 items - VitaminDWiki - Overview Schizophrenia and Vitamin D contains:
From MDEdge
Brain disorders, including mental illness, neurologic conditions, and stroke, account for more than 15% of all health loss worldwide – more than either cardiovascular disease or cancer – at huge cost to health care systems and society, an analysis of data from the most recent Global Burden of Disease (GBD) study shows.
“The burden of brain conditions will increase as populations continue to grow and age,” said study presenter Shayla Smith, MPH, an epidemiologist at the Institute for Health Metrics and Evaluation, the University of Washington, Seattle, in a press release.
“By 2050, more than 50 million people will be aged 65-79,” she explained, adding that the COVID-19 pandemic “has also influenced the prevalence of mental disorders globally, as people were forced to isolate and social networks broke down.”
Other factors related to brain disorders, she noted, include education level, obesity, and smoking.
“There’s still research to be done on what is the most effective way to maintain brain health, but some literature suggests a healthy brain can be achieved through a healthy lifestyle of managing conditions such as high blood pressure and diabetes, limiting alcohol consumption and smoking, prioritizing sleep, eating healthy, and staying physically and mentally active,” said Ms. Smith.
The findings were presented at the annual meeting of the Congress of the European Academy of Neurology.
An ‘ambitious exercise’
Coinvestigator Xaviera Steele, also from the IHME, told press conference attendees that the institute was established at the University of Washington in 2007 with the aim of “standardizing the measurement of health outcomes around the world and for all health conditions.”A central part of that is the GBD study, “which is a very ambitious exercise in descriptive epidemiology in an effort to systematically quantify health loss” due to disease, injury, and risk factors over time, stratified by country, region, age, and sex. In addition, researchers are mapping and projecting trends over the next century and are estimating disease expenditure by country, by type of expense, and by condition “to derive a health care access and quality score for each health system in the world,” Ms. Steele said.
They are also estimating exposure to risk factors, how those risk factors contribute to health burden, and associated health outcomes by race and ethnicity to reflect the “disparities that we know are very prevalent in countries such as the United States.” From that work, Ms. Steele said that brain health and related conditions “do emerge as one of the more pressing challenges of the 21st century.”
Increase in dementia, mental health conditionsThe data, which were gathered from 200,000 sources by the IHME, indicate that the number of individuals aged 65 years or older will increase by 350% by 2100. Ms. Steele underlined that “policy action will be needed to help families, who will struggle to provide high-quality care for their loved ones with dementia at a reasonable cost.”
The IHME calculates that in Europe health care spending on Alzheimer’s disease will increase by 226% between 2015 and 2040.
Turning to other conditions, Ms. Steele showed that since 1990, the number of individuals living with anxiety in the European region has increased by 14%, while the number living with depressive disorders has gone up by 13%.
Worldwide, the figures are even starker. Depression is estimated to affect 300 million people across the globe, which represents a 71% increase since 1990. The number of strokes increased by 95% over the same period.
Nevertheless, the “impact of brain conditions such as stroke has decreased since the 1990s due to improved treatments available,” Ms. Smith noted in the press release.
To estimate the toll caused by brain conditions, including neurologic disorders, mental disorders, cerebrovascular disease, brain cancer, brain injuries, and select infectious conditions, the researchers calculated disability-adjusted life years (DALYs*)
- Wikipedia. " It (DALY) not only includes the potential years of life lost due to premature death, but also includes equivalent years of 'healthy' life lost by virtue of being in states of poor health or disability."
This, Ms. Smith explained in her presentation, “captures the morbidity and mortality associated with brain conditions” and is adjusted for patient location, age, and sex.The investigators found that, globally, brain conditions accounted for more than 15% of all health loss in 2021, at 406 DALYs – more than the 206 million DALYs that were associated with cancer, and the 402 million that were linked to cardiovascular disease.
This health loss is associated with a $1.22 trillion loss in income for people living with health disorders worldwide and accounts for $1.14 trillion in direct health care costs.
The burden of mental disorders, neurologic conditions, and stroke is expected to increase dramatically between now and 2050, said Ms. Smith, who noted that health loss linked to brain conditions is higher in younger patients. This will create “new challenges for health systems, employers, patients, and families,” she said in the press release.
“Our goal is to see an improved prevention and treatment landscape for other brain conditions and reverse the growing health loss that we are currently forecasting.”
Worrying increase in stroke
Jurgita Valaikiene, MD, PhD, center of neurology, clinic of neurology and neurosurgery, Vilnius (Lithuania) University Faculty of Medicine, who chaired the session, was taken aback by the findings, particularly by the worldwide increase in stroke cases.“I work in stroke,” she said, and “we spend a lot of time on the diagnosis of stroke” and its prevention. “We try to be faster, to catch asymptomatic stenosis in the neck or head, and to apply the best medical treatment to avoid a stroke. But despite that, the numbers are increasing. I understand the population is getting older ... but still it’s a huge number.”
Dr. Valaikiene pointed out that stroke is not necessarily a condition of aging, insofar as increasing age “is not related directly to stenosis in the neck. “For example, we can have healthier vessels in older age and unhealthy vessels, with high-grade stenosis, in someone aged 30 or 40 years.”
“There are a lot of risk factors, such as smoking, physical activity, and so on. It depends on the individual,” she added.
The study was funded by the Institute for Health Metrics and Evaluation at the University of Washington. The authors have disclosed no relevant financial relationships.
The findings were presented at Congress of the European Academy of Neurology (EAN) 2023: Abstract EPO-236. Presented July 2, 2023.
Vitamin D inhaled thru the nose gets some directly to the brain
Inhaled Vitamin D
Perhaps drugs such as inhaled vitamin D can get directly to the brain – March 2018
Inhaled vitamin D helped lungs of new-born (rats) – Dec 2016 started my interest
Brain cells can probably activate Vitamin D without liver or kidney (at least in rats) – Sept 2017
Vitamin D activation is mainly done by the tissues, not the Liver and Kidneys
Vitamin D prevents/treats Multiple Sclerosis and 10 other brain disorders
VitaminDWiki – Alzheimer's-Cognition
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
- It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home.
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
There are 97+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+ studies
16+ studies in both categories Cognitive and Omega-3
VitaminDWiki – Stroke category has
131 items 131 items in stroke category - see also Overview Stroke and vitamin D,
Overview Hypertension and Vitamin D Overview Cardiovascular and vitamin DStroke more likely if low Vitamin D
- Stroke 74% less likely if high vitamin D (7,295 women 20-50 years old) – July 2017
- Stroke is 13.5 X more likely if low vitamin D and high blood pressure – March 2015
- Ischemic stroke 17 X more likely if low vitamin D – April 2017
- Stroke is strongly associated with Calcification of cerebral arteries (perhaps low Vitamin D, Vitamin K, Mg…) – March 2018
- Ischemic Stroke 3X more likely if Vitamin D Receptor gene change (Fok 1) – Jan 2014
Post-Stroke worse if low Vitamin D
- Poor Acute Ischemic Stroke 4X more likely if low Vitamin D - Nov 2023
- Stroke risks increased if low Vitamin D: Death 3.6 X, recurrence 5.5 X – Meta-analysis Nov 2019
- Stroke outcome at 3 months was 3X worse if bad stroke and low vitamin D – Jan 2020
- Death after Ischemic Stroke 2.5 X more likely if less than 10 ng of Vitamin D – May 2019
- Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Stroke incidence not associated with low Vitamin D (but stroke outcome is) – Aug 2019
Post-Stroke better if add Vitamin D
- Post-stroke Vitamin D supplementation helped in 11 ways – May 2023
- Improved recovery from ischemic stroke with Vitamin D (300,000 IU injection) – RCT June 2018
- Better outcome following Ischemic stroke if injected with 600,000 IU of vitamin D – RCT Feb 2017
- Ischaemic stroke – Vitamin D doubled survival (Injection followed by monthly 60,000 IU) – RCT Aug 2016
- Stroke patients need more than 2,000 IU of vitamin D (found this time in Japan) – RCT June 2019
Post-Stroke better if Vitamin D actually gets to cells
- Resveratrol fights Parkinson, Alzheimers, Diabetes, Cardiovascular, ALS, Stroke, etc.– Nov 2018
- Stroke rehabilitation (and prevention) requires Vitamin D actually getting to cells – March 2020
11 studies in both categories of Depression and Stroke This list is automatically updated
- Nerve cells and Vitamin D – many studies
- Water-soluble form of vitamins are needed for some health problems
- Post-stroke depression not reduced by 2,000 IU of vitamin D (not a surprise) – Nov 2021
- Depression is associated with stroke if low vitamin D or winter – Nov 2018
- Depression following a stroke is 2.7 X more likely if low vitamin D – Sept 2018
- Omega-3 and Vitamin D each treat many mental health problems - April 2018
- MAGNESIUM IN MAN - IMPLICATIONS FOR HEALTH AND DISEASE – review 2015
- No longer depressed, but risk of stroke is still 1.7X higher (did not consider low vitamin D) – May 2015
- ALL of the top 10 health problems of women are associated with low vitamin D
- Post stroke depression 9X more likely if low vitamin D – Dec 2014
- Stroke patients with low vitamin D were 10X more likely to become depressed – Aug 2014
VitaminDWiki – Autism category has
163 items Autism category has 163 items - see also Overview Autism and vitamin D, Autoimmune , Cognitive, ADHD
Interesting Autistic studies
Autism associated with low Vitamin D- Most Autism Risk factors are associated with low vitamin D - March 2014
- Rickets – 26 percent had autism: no rickets, no autism (both associated with low vitamin D) – June 2015
- Autistics have half of the response to Vitamin D – RCT Oct 2018
- Vitamin D fights autism - trying to figure out how and why – May 2022
Autism treated by Vitamin D
- Autism risk is reduced by Vitamin D – early pregnancy or chlldhood – Umbrella review – July 2024
- Autism treated by Vitamin D (monthly injection of 150,000 IU) – June 2017
- Autism decreased in 8 out of 10 children supplemented with vitamin D – April 2015
Autism reduced by vitamins before and during pregnancy
- Autism reduced 24% for each 4 ng more Vitamin D while pregnant ( ADHD 12%) – Feb 2024
- Low maternal Vitamin D results in larger portion of brain associated with autism – Jan 2020
- Autism risk reduced 2X by prenatal vitamins (Vitamin D or Folic) – Feb 2019
- Autism 3X more likely after closely spaced pregnancy vs 3 year apart– Jan 2011
- Low Vitamin D decreases fertility and increases subsequent autism, ADHD, etc – Feb 2018
- Women who had supplemented with any vitamins were 6 X less likely to have autistic offspring – Jan 2018
- Autism rate in siblings reduced 4X by vitamin D: 5,000 IU during pregnancy, 1,000 IU to infants – Feb 2016
Autism and Vitamin D Receptor (not enough Vit D gets to the cells)
This list is automatically updated- More than 30% of Autistics also have ADHD - Nov 2024
- Autism treated by an activator of the Vitamin D Receptor: supforaphane - March 2024
- Autism may be synergistically treated by Vitamin D and probiotics – July 2022
- Autism 2X to 3X more likely if poor Vitamin D Receptor – June 2020
- A good Vitamin D Receptor (or perhaps more vitamin D) protects against lead during pregnancy
- Autism much more likely if poor Vitamin D Receptor – many studies
Autism - other risk factors
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Autism risk increased if infant had antibiotics (2X), acetaminophen (3X), or no vitamin D drops (1.5X) – June 2018
- 20 X more Parkinson's and 100X more Autism with GMO soy in China
- Note >100X increase in Autism while having GMO soy in the US
6 Autism and Virus/Vaccines - Fewer neurons in males born from COVID-19 vaccinated mothers (rats) - Jan 2024
- Vaccinations resulted in increased office visits for children 16 months later - Nov 2020
- Does a vaccine increase the risk of Autism – March 2019
- Autism 2.75 X more likely in Hib vaccines containing Mercury – May 2018
- Vaccinated children had more chronic diseases - Sept 2018
- Autism and ADHD type disorders were 14X more likely in survey of extreme preterm vaccinated infants - April 2017
Dr. Cannell on Autism and Vitamin D in VitaminDWiki
- Autism treated by Vitamin D (80 – 120 ng) – Cannell update May 2018
- Autism Causes, Prevention and Treatment: Vitamin D Deficiency etc. – Book April 2015 Cannell
- Autism cured in a child with Vitamin D, Dr. Cannell comments and cofactor recommendations – March 2015
- Autism and Vitamin D - Dr. Cannell in Life Extension Mag - Jan 2014
- Autism treated by Vitamin D: Dr. Cannell - video June 2013
- includes his list of 27 reasons to associate Vitamin D with Autism in 2013
7 studies: Autism reduced by Omega-3 - Many autistic children are getting some Vitamin D, Omega-3, probiotics, etc. – Aug 2019
- Autistic symptoms reduced by Vitamin D and or Omega-3 – RCT March 2019
- Omega-3 probably can decrease Autism and ADHD – March 2019
- Autism treated in one person by Omega-3 plus Vitamin D – Dec 2018
- Autism problems reduced by Vitamin D, Omega-3 – RCT Oct 2018
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Autism risks include chemicals, deficiency of vitamin D, Omega-3 – mini-review April 2016
VitaminDWiki – Parkinson's category has
117 items - Vitamin D associated with Parkinson’s Disease in 55 studies, more studies needed- March 2022
- Parkinson's category has
117 studies - Parkinson’s Disease and Vitamin D – review of 52 studies – May 2022
- Parkinson patients: 60 % taking Vitamin D – Dec 2019
- Low Vitamin D increases Parkinson's by 3X– July 2010 "only" a 30 year test, need more study
- Parkinson's disease prevented by Vitamin D, but small doses do not treat it - Aug 2023
- 10 clinical trials for PD with vitamin D intervention as of June 2023
- Parkinson’s Disease Summer School – alternative therapies included 60-80 ng of Vitamin D – Sept 2019
- Associated with PD are: Meta-analyses (
12 ), Cognition ( 24 studies), Multiple Sclerosis ( 18 studies), VIRUS ( 4 studies), Omega-3 ( 3 studies), Vitamin D Receptor ( 11 studies) - Note by the Founder of VitaminDWiki: I have twice recommended lots of Vitamin D to treat PD. Both got much better, but one had his doctor him cut back to just 2,000 IU. All of his recovery got reversed. With lots of vitamin D he could sing and bike, but now he can barely talk or walk
VitaminDWiki - Attention Deficit Hyperactivity Disorder
ADHD and Vitamin D Deficiency category listing has 44 items
ADHD children have much lower levels of vitamin D
ADHD is more likely if low vitamin D in early pregnancy
Less sun is associated with more ADHD (season and latitude)
The ADHD rate has increased a lot in the past few decades - especially for adults
Vitamin D levels have dropped a lot in the past few decades
There are many positive observational studies of Vitamin D and ADHD
ADHD shares risk factors with Autism and many other diseases:
Low Vitamin D, Low Omega-3, Low Magnesium, Low UVB (= high latitude or winter)
ADHD has been treated by each of: Vitamin D, Omega-3, Magnesium, and Zinc
VitaminDWiki - Amyotrophic Lateral Sclerosis- 27+ items
VitaminDWiki - Bipolar Disorder
16 items
VitaminDWiki - Brain - 98 items
VitaminDWiki – Depression category has
268 items
VitaminDWiki – Multiple Sclerosis category has
412 items
VitaminDWiki - Overview Schizophrenia and Vitamin D contains:
14 reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restoredGlobal burden of brain disorders surpasses cardiovascular disease and cancer - July 20236736 visitors, last modified 19 Jul, 2023, This page is in the following categories (# of items in each category)
- VitaminDWiki – Autism category has