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2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004

Vitamin D supplementation during the first year of life and risk of schizophrenia: a Finnish birth cohort study.

Schizophr Res. 2004 Apr 1;67(2-3):237-45.
McGrath J1, Saari K, Hakko H, Jokelainen J, Jones P, Järvelin MR, Chant D, Isohanni M.
Department of Psychiatry, University of Cambridge, Cambridge, UK. john_mcgrath at qcsr.uq.edu.au

OBJECTIVE:
Based on clues from epidemiology and animal experiments, low vitamin D during early life has been proposed as a risk factor for schizophrenia. The aim of this study was to explore the association between the use of vitamin D supplements during the first year of life and risk of developing schizophrenia.

METHOD:
Subjects were drawn from the Northern Finland 1966 Birth Cohort (n=9,114). During the first year of life, data were collected about the frequency and dose of vitamin D supplementation. Our primary outcome measures were schizophrenia, psychotic disorders other than schizophrenia, and nonpsychotic disorders as diagnosed by age 31 years. Males and females were examined separately.

RESULTS:
In males, the use of either irregular or regular vitamin D supplements was associated with a reduced risk of schizophrenia (Risk ratio (RR)=0.08, 95% CI 0.01-0.95; RR=0.12, 95% CI 0.02-0.90, respectively) compared with no supplementation. In males, the use of at least 2000 IU of vitamin D was associated with a reduced risk of schizophrenia (RR=0.23, 95% CI 0.06-0.95) compared to those on lower doses. There were no significant associations between either the frequency or dose of vitamin D supplements and (a) schizophrenia in females, nor with (b) nonpsychotic disorder or psychotic disorders other than schizophrenia in either males or females.

CONCLUSION:
Vitamin D supplementation during the first year of life is associated with a reduced risk of schizophrenia in males. Preventing hypovitaminosis D during early life may reduce the incidence of schizophrenia.

PMID: 14984883

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See also VitaminDWiki

see wikipage: http://www.vitamindwiki.com/tiki-index.php?page_id=1660
Chart by Wagner and Hollis,  downloaded from Grassroots April 2010 – also

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