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Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014

Depression, Low Vitamin D Major Risk Factors for Dementia Healthline

Press statement "We expected to find an association between low vitamin D levels and the risk of dementia and Alzheimer's disease, but the results were surprising — we actually found that the association was twice as strong as we anticipated,”

Vitamin D and the risk of dementia and Alzheimer disease

Neurology published online August 6, 2014
Thomas J. Littlejohns, MSc, William E. Henley, PhD, Iain A. Lang, PhD, Cedric Annweiler, MD, PhD, Olivier Beauchet, MD, PhD, Paulo H.M. Chaves, MD, PhD, Linda Fried, MD, MPH, Bryan R. Kestenbaum, MD, MS, Lewis H. Kuller, MD, DrPH, Kenneth M. Langa, MD, PhD, Oscar L. Lopez, MD, Katarina Kos, MD, PhD, Maya Soni, PhD* and David J. Llewellyn, PhD david.llewellyn at exeter.ac.uk

Abstract results
During a mean follow-up of 5.6 years, 171 participants developed all-cause dementia, including 102 cases of Alzheimer disease. Using Cox proportional hazards models, the multivariate adjusted hazard ratios (95% confidence interval [CI]) for incident all-cause dementia in participants who were severely 25(OH)D deficient (<25 nmol/L) and deficient (≥25 to <50 nmol/L) were 2.25 (95% CI: 1.23–4.13) and 1.53 (95% CI: 1.06–2.21) compared to participants with sufficient concentrations (≥50 nmol/L). The multivariate adjusted hazard ratios for incident Alzheimer disease in participants who were severely 25(OH)D deficient and deficient compared to participants with sufficient concentrations were 2.22 (95% CI: 1.02–4.83) and 1.69 (95% CI: 1.06–2.69). In multivariate adjusted penalized smoothing spline plots, the risk of all-cause dementia and Alzheimer disease markedly increased below a threshold of 50 nmol/L.

Image Image

Summary table by VitaminDWiki

Health Problem
when < 10ng
Increase compared to those
with > 20 ng of Vitamin D
Dementia 2.25X

The surprise is that they found such a low association
- previous studies found much stronger associations

PDF is attached at the bottom of this page

Women 3X more likely to get dementia if prviously had low vitamin D - Sept 2014

Serum 25-Hydroxyvitamin D Concentration and Risk of Dementia
Epidemiology. 2014 Sep 11. [Epub ahead of print]
Knekt P1, Sääksjärvi K, Järvinen R, Marniemi J, Männistö S, Kanerva N, Heliövaara M.

High vitamin D status has been hypothesized to protect against dementia. The aim of the current study was to investigate whether serum 25-hydroxyvitamin D (25(OH)D) level predicts dementia risk.
The study was based on the Mini-Finland Health Survey. The study population consisted of 5010 men and women, aged 40-79 years, and free of dementia at baseline. During a 17-year follow up, 151 incident cases of dementia (International Classification of Diseases, revision 8, code 290) occurred, according to population registers. Serum 25(OH)D concentration was determined from serum samples frozen at -20°C and stored at baseline.
Among women, these with higher serum 25(OH)D concentrations showed a reduced risk of dementia.
The hazard ratio between the highest and lowest quartiles of serum 25(OH)D was 0.33 (95% confidence interval = 0.15-0.73) in women
and 0.74 (0.29-1.88) in men, after adjustment for age, month of blood draw, education, marital status, physical activity, smoking, alcohol consumption, body mass index, blood pressure, plasma fasting glucose, serum triglycerides, and serum total cholesterol.
The results are in line with the hypothesis that low vitamin D status may be a risk factor for dementia.
PMID: 25215530

See also VitaminDWiki

Age Adjusted Death from Dementia (Finland)
Dementia death rate - age standardized @is.gd/increasedisease
and has the following summary (some of the following hyperlinks below do not work on this page - you have to go to the Overview page)

The TOP articles in Cognitive and Vitamin D are listed here:

See also web

Attached files

ID Name Comment Uploaded Size Downloads
4240 Dementia F2.jpg admin 06 Aug, 2014 20:55 21.76 Kb 1142
4239 Dementia.jpg admin 06 Aug, 2014 20:55 36.74 Kb 2428
4238 Dementia surprise.pdf PDF 2014 admin 06 Aug, 2014 20:54 585.37 Kb 889
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