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Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022

Rate of conversion from mild cognitive impairment to dementia in a Thai hospital-based population: A retrospective cohort

Alzheimers Dement (N Y). 2022; 8(1) 2022 Mar 31. doi: 10.1002/trc2.12272
Papan Thaipisuttikul, corresponding author 1 Kriengsak Jaikla, 1 Sirikorn Satthong, 1 and Pattarabhorn Wisajun 1

Subset of table in PDF
Mild cognitive impairment (MCI) is the state between normal cognition and dementia. This study objective was to estimate an average 1-year rate of conversion from MCI to dementia and explore the associated factors of conversion in a hospital-based cohort.

A retrospective cohort study of participants with MCI was conducted in a tertiary care hospital in Thailand. Two hundred fifty participants, 50 years of age or older, were enrolled.

An average 1-year conversion rate from MCI to dementia was 18.4%. MCI patients who converted to dementia were likely older (P < .001), predominantly female (P = .028), vitamin D deficient (P = .012), and associated with lower Mini–Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores during first assessments (P < .001, P < .001 respectively) and follow-up assessments (P < .045, P < .001 respectively). We conducted two models of multivariate analysis, using binary logistic regression.
In the first model, adjusted for age, sex, education, vitamin D deficiency, and first assessment MMSE scores, we found that underlying vitamin D deficiency (odds ratio [OR] = 3.13, 95% confidence interval [CI] 1.04 to 9.44) and first assessment MMSE scores (OR = 0.83, 95% CI 0.73 to 0.93) were significantly associated with conversion to dementia.
In the second model, adjusted for age, sex, education, vitamin D deficiency and first assessment MoCA scores, only first assessment MoCA scores (OR = 0.58, 95% CI 0.45 to 0.76) were significantly associated with conversion to dementia.

The 1-year conversion rate from MCI to dementia was 18.4%. MMSE and MoCA were useful tools to assess baseline cognitive status in MCI patients and predict dementia progression. The association between vitamin D deficiency and risk of conversion from MCI to dementia requires further investigations.
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VitaminDWiki - Cognitive category starts

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

365 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (48 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (22 studies), Parkinson's (21 studies)
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Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

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VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D starts

VitaminDWiki - Cognitive Intervention (give Vitamin D and see what happens)

VitaminDWiki - Meta-analyses of Cognituve

VitaminDWiki - BOTH the categories Cognitive and Omega-3

VitaminDWiki - End of Alxheimer's

End of Alzheimer's video and transcript - Oct 2021

Created by admin. Last Modification: Thursday April 7, 2022 14:11:59 GMT-0000 by admin. (Version 9)

Attached files

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17345 Cognition dementia.jpg admin 07 Apr, 2022 13:40 27.49 Kb 165
17344 mild cognitive impairment lead to dementia.pdf PDF 2022 admin 07 Apr, 2022 13:40 605.08 Kb 104