Table of contents
- Rate of conversion from mild cognitive impairment to dementia in a Thai hospital-based population: A retrospective cohort
- VitaminDWiki - Cognitive category starts
- VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D starts
- VitaminDWiki - Cognitive Intervention (give Vitamin D and see what happens)
- VitaminDWiki - Meta-analyses of Cognituve
- VitaminDWiki - BOTH the categories Cognitive and Omega-3
- VitaminDWiki - End of Alxheimer's
Rate of conversion from mild cognitive impairment to dementia in a Thai hospital-based population: A retrospective cohort
Alzheimers Dement (N Y). 2022; 8(1) 2022 Mar 31. doi: 10.1002/trc2.12272
Papan Thaipisuttikul, corresponding author 1 Kriengsak Jaikla, 1 Sirikorn Satthong, 1 and Pattarabhorn Wisajun 1
Subset of table in PDF
Introduction
Mild cognitive impairment (MCI) is the state between normal cognition and dementia. This study objective was to estimate an average 1-year rate of conversion from MCI to dementia and explore the associated factors of conversion in a hospital-based cohort.
Methods
A retrospective cohort study of participants with MCI was conducted in a tertiary care hospital in Thailand. Two hundred fifty participants, 50 years of age or older, were enrolled.
Results
An average 1-year conversion rate from MCI to dementia was 18.4%. MCI patients who converted to dementia were likely older (P < .001), predominantly female (P = .028), vitamin D deficient (P = .012), and associated with lower Mini–Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores during first assessments (P < .001, P < .001 respectively) and follow-up assessments (P < .045, P < .001 respectively). We conducted two models of multivariate analysis, using binary logistic regression.
In the first model, adjusted for age, sex, education, vitamin D deficiency, and first assessment MMSE scores, we found that underlying vitamin D deficiency (odds ratio [OR] = 3.13, 95% confidence interval [CI] 1.04 to 9.44) and first assessment MMSE scores (OR = 0.83, 95% CI 0.73 to 0.93) were significantly associated with conversion to dementia.
In the second model, adjusted for age, sex, education, vitamin D deficiency and first assessment MoCA scores, only first assessment MoCA scores (OR = 0.58, 95% CI 0.45 to 0.76) were significantly associated with conversion to dementia.
Discussion
The 1-year conversion rate from MCI to dementia was 18.4%. MMSE and MoCA were useful tools to assess baseline cognitive status in MCI patients and predict dementia progression. The association between vitamin D deficiency and risk of conversion from MCI to dementia requires further investigations.
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VitaminDWiki - Cognitive category starts
Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items
see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D
Cardiovascular (
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Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023
Types of evidence that Vitamin D helps brain problems - 2014
VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D starts
- FACT: Cognitive decline is 19X more likely if low vitamin D
- FACT: Dementia is associated with low vitamin D levels.
- FACT: Alzheimer’s Dementia 2.3X more likely in elderly if low vitamin D – Dec 2022
- FACT: Dementia is associated with low vitamin D - many studies
- FACT: Alzheimer's Disease is 4X less likely if high vitamin D
- FACT: Every single risk factor listed for Alzheimer's Disease is also a risk factor for low vitamin D levels
- FACT: Elderly cognition gets worse as the elderly vitamin D levels get even lower (while in senior homes)
- OBSERVATION: Reports of increased vitamin D levels result in improved cognition
- OBSERVATION: Alzheimer’s patients 3X more likely to have a malfunctioning vitamin D receptor gene – 2012
- OBSERVATION: Alzheimer's Disease has been seen to halt when vitamin D was added.
- OBSERVATION: Alzheimer’s is associated with all 7 of the genes which restrict vitamin D
- OBSERVATION: 39 vitamin D and Alz. or Cognition intervention trials as of Sept 2018
- OBSERVATION: 2 Meta-analysis in 2012 agreed that Alzheimer's Disease. associated with low vitamin D
- OBSERVATION: 50X increase in Alzheimer's while decrease in vitamin D
- OBSERVATION: Vitamin D reduces Alzheimer’s disease in 11 ways
- OBSERVATION: Alzheimer’s cognition improved by 4,000 IU of vitamin D
- OBSERVATION: Plaque removed in mice by equiv. of 14,000 IU daily
- OBSERVATION: DDT (which decreases Vit D) increases risk of Alzheimer's by up to 3.8X
- OBSERVATION: 2% of people have 2 copies of the poor gene reference: Alz Org
- OBSERVATION: Genes do not change rapidly enough to account for the huge increase in incidence
- OBSERVATION: End of Alzheimer's videos, transcripts and many studies protocol has been very successful
- It adjusts Vitamin D, B-12, Iron, Omega-3, food, etc, and can now be done at home. $75/month.
- FACT: Vitamin D is extremely low cost and has very very few side effects
- CONCLUSION: Everyone concerned about cognitive decline or Alzheimer's Disease should take vitamin D
- PREDICTION MET: By 2024 Omega-3 and high dose Vitamin D will be found to reverse Alzheimer's in humans
There are 13+ Alzheimer’s meta-analyses in VitaminDWiki
There are 97+ Alzheimer’s studies in VitaminDWiki
Dementia is associated with low vitamin D - many studies 50+ studies
16+ studies in both categories Cognitive and Omega-3
VitaminDWiki - Cognitive Intervention (give Vitamin D and see what happens)
- APOE-04 Alzheimer’s progression slowed up by Omega-3 – RCT Aug 2024
- Senior cognition improved in 4 ways by Vitamin D (50,000 IU weekly for 8 weeks) – Sept 2023
- Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
- Mild cognitive decline reversed by a year of just 800 IU Vitamin D daily – RCT Dec 2020
- Methadone cognition improved by 50,000 IU of vitamin D every 2 weeks – RCT May 2019
- Schizophrenia reduced by biweekly 50,000 IU Vitamin D and probiotics – RCT Feb 2019
- Cognitive function of adult women improved in 3 months of 50,000 IU weekly Vitamin D – Jan 2019
- Amyloid brain plaque both prevented and removed by high vitamin D (in mice) – Aug 2018
- Cognition improved a tiny amount with 400 IU of vitamin D (not a surprise) – RCT Oct 2018
- 9,000 dollar prize for RCT which found cognition improved after taking 4,000 IU of Vitamin D for 18 weeks – May 2018
- Senior cognition improved somewhat by 4,000 IU of Vitamin D (if initially less than 30 ng) – RCT April 2017
- Vitamin D and Glutamine reduced Trauma Center deaths by half – Matthews March 2017
- Mental health intervention trials using enough vitamin D for long enough found benefits – Jan 2017
- Visual memory improved a bit by vitamin D if start with less than 30 ng – RCT Jan 2017
- Cognition of Alzheimer’s patients improved by daily 4,000 IU of vitamin D – RCT Jan 2015
- 2,000 IU of vitamin D reduced schizophrenia chance by 77 percent (male infants) - 2004
- Better memory if take lots of vitamin D (senior rats) – May 2015
- Severe Alzheimer's delayed by 1 year with vitamin D intervention – March 2014
- Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012
- Age-related cognitive decline in rats mitigated by Vitamin D intervention – RCT Oct 2012
VitaminDWiki - Meta-analyses of Cognituve
- Alzheimer’s 1.6X more likely if vitamin D is less than 25 ng – meta-analysis July 2023
- Alzheimer’s patients have less Magnesium – meta-analysis Jan 2022
- Delirium or cognitive problems after surgery 1.5X more likely if low vitamin D –meta-analysis Aug 2022
- 2X higher risk of Alzheimer’s if poor Vitamin D Receptor – Meta-analysis June 2021
- Alzheimer’s Disease risk is 1.9 X higher if Vitamin D deficient- meta-analysis Feb 2020
- Alzheimer’s Disease risk is 1.3X higher if Vitamin D deficient – meta-analysis Nov 2019
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Alzheimer's risk increased 7 percent for every 4 ng decrease in Vitamin D– meta-analysis Nov 2018
- Dementia is associated with low vitamin D - many studies
- Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018
- Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
- Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017
- Omega-3 helps childhood cognition – meta-analysis April 2016
- Poor cognition associated with low vitamin D in elderly (Asians now too) – meta-analysis March 2016
- Cognitive decline in elderly slowed by Omega-3 – meta-analysis May 2015
- Alzheimer’s disease 21 percent more likely if low vitamin D – meta-analysis Aug 2015
- Parkinson's and Alzheimer's: associations with vitamin D receptor genes and race – meta-analysis July 2014
- Brain (Alzheimer’s) worked better with Vitamin D intervention – meta-analysis July 2013
- Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013
- Alzheimer's Disease more likely with low vitamin D – meta-analysis Oct 2012
- Alzheimer disease associated with 2.5 ng less vitamin D – meta-analysis Sept 2012
- Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012
VitaminDWiki - BOTH the categories Cognitive and Omega-3
- Risk of Alzheimer’s is decreased by food, supplements, and lifestyle – Aug 2024
- APOE-04 Alzheimer’s progression slowed up by Omega-3 – RCT Aug 2024
- Dementia prevented by Omega-3, Vitamin D, etc. book and video May 2024
- Better cognition associated with higher Omega-3 index – Sept 2023
- Alzheimer’s delayed 4.7 years by high Omega-3 index (7.6 years if also have APOE-4) June - 2022
- Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021
- Early brain development helped by Iron, Iodine, Vitamin D, Omega-3. Zinc etc. – Oct 2021
- Omega-3 paused Alzheimer's decline - RCT Sept 2021
- Seafood (Omega-3) during pregnancy increased childhood IQ by 8 points – review Dec 2019
- Omega-3 index of 6 to 7 associated with best cognition in this study – Nov 2019
- Eating fish improves cognition (Omega-3 fish during pregnancy in this case) - Oct 2019
- Mental disorders fought by Omega-3 etc. - meta-meta-analysis Oct 2019
- Omega-3 prevents Parkinson’s Disease – Review of RCT July 2019
- Omega-3 helps brains of seniors – May 2019
- Omega-3 helped Alzheimer’s only if good level of B vitamins – RCT April 2019
- Standard Omega-3 not get past blood-brain barrier in seniors at high risk of Alzheimer’s – Patrick hypothesis Oct 2018
- APOE4 gene problems (Alzheimer’s) reduced by both Vitamin D and Omega-3 - Dec 2018
- Omega-3 is important for Brain Health during all phases of life – Aug 2018
- Hypothesis: Omega-3 reduces Alzheimer’s directly and via the gut – Sept 2018
- Improve Cognitive Health and Memory with Vitamin D and Omega-3 – World Patent March 2018
- IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
- Adding Vitamin D, Omega-3, etc to children’s milk improved memory (yet again) – RCT June 2018
- Omega-3, Vitamin D, Folic acid etc. during pregnancy and subsequent mental illness of child – March 2018
- Why Alzheimer’s studies using Omega-3 have mixed results – quality, dose size, Omega-6, genes, etc. March 2018
- Benefits of Omega-3 beyond heart health - LEF Feb 2018
- Supplementation while pregnant and psychotic – 20 percent Omega-3, 6 percent Vitamin D – June 2016
- ADHD, Autism, Early Psychosis and Omega-3 – review Dec 2017
- Mild Traumatic Brain Injury prevented with Omega-3, Resveratrol, etc (in rats) – Oct 2017
- Omega-3 found to treat Alzheimer’s and Parkinson’s in animals – Sept 2017
- The End of Alzheimer's and Dementia if adjust Vitamin D, B-12, Iron, Omega-3, etc.
- Violent schizophrenia patients treated by 3 months of Omega-3 – RCT Aug 2017
- Psychosis risk reduced for 80 weeks by just 12 weeks of Omega-3 – RCT Aug 2017
- Alzheimer’s (apoE4) may require more than Omega-3 - May 2017
- Infants getting 1 g of Omega-3 for 12 weeks got better brains – RCT March 2017
- Omega-3 reduces many psychiatric disorders – 2 reviews 2016
- Cognitive Impairment 1.8 times more likely if low Omega-3– Oct 2016
- Omega-3 may treat schizophrenia
- Benefits of Omega-3 on brain development
- Omega-3 helps childhood cognition – meta-analysis April 2016
- Football Brain injuries prevented by Omega-3 – RCT Jan 2016
- Schizophrenia treated by 6 months of Omega-3 – RCT Nov 2015
- Omega-3 and infant development - dissertation Sept 2015
- Omega-3 etc improved both cognition and mobility of older women – Aug 2015
- Schizophrenia relapses reduced 3X by Omega-3 – RCT Mar 2015
- Cognitive decline in elderly slowed by Omega-3 – meta-analysis May 2015
- Cognitively impaired brain atrophy was slowed 40 percent by Omega-3 and B vitamins – RCT July 2015
- Omega-3, Vitamin D, and other nutrients decrease mental health problems – March 2015
- Vitamin D, Omega-3 supplementation helps cognition – perhaps due to serotonin – Feb 2015
- Vitamin D and Omega-3 may reduce cortical atrophy with age – Nov 2013
- Alzheimer’s and Vitamins D, B, C, E, as well as Omega-3, metals, etc. – June 2013
VitaminDWiki - End of Alxheimer's
End of Alzheimer's video and transcript - Oct 2021
- Dr. Bredsen 40-60 ng Vitamin D, Omega-3, B-12, etc
- Included in the following table: Comparing High-dose vitamin D therapies
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