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Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022


Rate of conversion from mild cognitive impairment to dementia in a Thai hospital-based population: A retrospective cohort

Alzheimers Dement (N Y). 2022; 8(1) 2022 Mar 31. doi: 10.1002/trc2.12272
Papan Thaipisuttikul, corresponding author 1 Kriengsak Jaikla, 1 Sirikorn Satthong, 1 and Pattarabhorn Wisajun 1

Subset of table in PDF
Image
Introduction
Mild cognitive impairment (MCI) is the state between normal cognition and dementia. This study objective was to estimate an average 1-year rate of conversion from MCI to dementia and explore the associated factors of conversion in a hospital-based cohort.

Methods
A retrospective cohort study of participants with MCI was conducted in a tertiary care hospital in Thailand. Two hundred fifty participants, 50 years of age or older, were enrolled.

Results
An average 1-year conversion rate from MCI to dementia was 18.4%. MCI patients who converted to dementia were likely older (P < .001), predominantly female (P = .028), vitamin D deficient (P = .012), and associated with lower Mini–Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores during first assessments (P < .001, P < .001 respectively) and follow-up assessments (P < .045, P < .001 respectively). We conducted two models of multivariate analysis, using binary logistic regression.
In the first model, adjusted for age, sex, education, vitamin D deficiency, and first assessment MMSE scores, we found that underlying vitamin D deficiency (odds ratio [OR] = 3.13, 95% confidence interval [CI] 1.04 to 9.44) and first assessment MMSE scores (OR = 0.83, 95% CI 0.73 to 0.93) were significantly associated with conversion to dementia.
In the second model, adjusted for age, sex, education, vitamin D deficiency and first assessment MoCA scores, only first assessment MoCA scores (OR = 0.58, 95% CI 0.45 to 0.76) were significantly associated with conversion to dementia.

Discussion
The 1-year conversion rate from MCI to dementia was 18.4%. MMSE and MoCA were useful tools to assess baseline cognitive status in MCI patients and predict dementia progression. The association between vitamin D deficiency and risk of conversion from MCI to dementia requires further investigations.
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VitaminDWiki - Cognitive category starts

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used
Dementia page - 50 items

373 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (7 studies), Genetics (9 studies), Vitamin D Receptor (16 studies), Omega-3 (49 studies), Intervention (19 studies), Meta-analyses (22 studies), Depression (23 studies), Parkinson's (22 studies)
Click here for details

Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 325 items as of March 2023

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392


VitaminDWiki - Overview Alzheimer's-Cognition and Vitamin D starts


VitaminDWiki - Cognitive Intervention (give Vitamin D and see what happens)


VitaminDWiki - Meta-analyses of Cognituve


VitaminDWiki - BOTH the categories Cognitive and Omega-3


VitaminDWiki - End of Alxheimer's

End of Alzheimer's video and transcript - Oct 2021


Created by admin. Last Modification: Thursday April 7, 2022 14:11:59 GMT-0000 by admin. (Version 9)

Attached files

ID Name Comment Uploaded Size Downloads
17345 Cognition dementia.jpg admin 07 Apr, 2022 27.49 Kb 191
17344 mild cognitive impairment lead to dementia.pdf admin 07 Apr, 2022 605.08 Kb 143