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Toggle Health Problems and D

Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021


A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community

J Alzheimers Dis. 2021 Nov 18. doi: 10.3233/JAD-215011
Jeanne Neuffer 1, Marjorie Gourru 1, Aline Thomas 1, Sophie Lefèvre-Arbogast 1, Alexandra Foubert-Samier 2, Catherine Helmer 1, Cécile Delcourt 1, Catherine Féart 1, Cécilia Samieri 1

Background: Low blood status in several nutritional compounds, including long-chain omega-3 fatty acids (LC n-3 PUFA), carotenoids, and vitamin D, have been associated with a higher risk to develop dementia. Nutritional deficiencies may potentiate each other regarding dementia risk; yet the association of multiple nutritional deficiencies with dementia has been little explored.

Objective: To develop an index of micronutritional biological status (MNBS) for the screening of multi-micronutritional deficiencies associated with the risk of dementia in a prospective population-based cohort of older persons.

Methods: We included participants from the Bordeaux Three-City study, who were free of dementia at baseline, had blood measurements of LC n-3 PUFA, carotenoids, and 25(OH)D, and who were followed for up to 18 years for dementia. We used penalized splines in Cox models to model dose-response relationships of each nutritional component with the risk of dementia and construct a risk index.

Results: 629 participants with an average age of 73.1 years were included in the study. Each increase of 1 SD of the MNBS index was associated with a 46%higher risk of dementia (HR = 1.46, 95%CI 1.23; 1.73). Participants with highest index (mean+1SD; max) had a 4-fold increased risk of dementia compared with participants with a low index (min; mean-1SD) (HR = 4.17, 95%CI 2.30; 7.57).

Conclusion: This index of assessment of micronutritional biological status is a practical tool that may help identify populations with inadequate nutritional status, screen eligible individuals for nutritional prevention in primary care, or for supplementation in preventive trials of dementia.


VitaminDWiki - Cognition and Vitamin D - a few studies

Genes restrict vitamin D from getting to brain cells

Getting Vitamin D reduces or halt cognitive decline

VitaminDWiki - Cognitive and Omega-3 studies

VitaminDWiki - Cognitive category starts with

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

326 items in Cognition category

see also Overview Alzheimer's-Cognition and Vitamin D
Overview Parkinson's and Vitamin D

Studies in both categories of Cognition and:
Cardiovascular (6 studies), Genetics (8 studies), Vitamin D Receptor (15 studies), Omega-3 (48 studies), Intervention (18 studies), Meta-analyses (21 studies), Depression (21 studies), Parlinson's (16 studies),  Click here for details

Vitamin D pages containing "Dementia" in title (40 as of April 2022)
Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017
Every schizophrenia measure was improved when vitamin D levels were normalized – June 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020
IQ levels around the world are falling (perhaps lower Vitamin D, Iodine, or Omega-3)
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392

VitaminDWiki - Alzheimers-Cognition - Overview starts with

VitaminDWiki - Overview Schizophrenia and Vitamin D starts with

Many reasons to think that schizophrenia is associated with low vitamin D
1) 97% of patients with schizophrenia are vitamin D deficient
2) Schizophrenia varies with latitude (UVB) by 10X (controversy)
3) Schizophrenia is more common in those with dark skin (when away from the equator)
4) Schizophrenia is associated with low natal vitamin D
5) Schizophrenia has been increasing around the world when vitamin D has been decreasing (controversy)
6) Schizophrenia is associated with low birth rate, which is associated with low vitamin D
7) Schizophrenia is associated with Autism which is associated with low vitamin D
8) Schizophrenia Bulletin Editorial (Jan 2014) speculated that Vitamin D could be a major player
9) Schizophrenia 2X more likely if low vitamin D - meta-analysis
10) Schizophrenia increased 40 % for Spring births after Danes stopped vitamin D fortification
11) Schizophrenia is associated with season of birth
12) Schizophrenia is associated with poor Vitamin D Receptor genes
13) Schizophrenia risk is decreased if give Vitamin D after birth
14) Schizophrenia symptoms reduced when Vitamin D levels are restored


VitaminDWiki pages with DEMENTIA in title (40 as of May 2022)

This list is automatically updated

Items found: 41
Title Modified
Dementia is associated with low vitamin D - several studies 15 Jun, 2022
Vitamin Supplementation and Dementia - Review May 2022 11 May, 2022
Lewy Body Dementia (Robin Williams) and low Vitamin D 11 May, 2022
Dementia 10X lower in a group who are outdoors a lot and eat unprocessed foods - March 2022 07 Apr, 2022
Mild cognitive impairment is 3X more likely to become dementia in one year if low vitamin D – March 2022 07 Apr, 2022
Dementia 1.7X higher risk if diabetic and low vitamin D - Jan 2022 14 Feb, 2022
Dementia 4.1 X high risk in those with low Vitamin D, Omega-3, etc.2 decades before (behind paywall) – Nov 2021 22 Nov, 2021
Dementia reduced 26 percent after pollution was reduced a decade earlier (probably higher Vitamin D) – Aug 2021 19 Aug, 2021
Cognitive Impairment and Dementia often associated with low Vitamin D – April 2020 08 Jan, 2021
The Evidence is strong: Air pollution seems to cause dementia (perhaps low Vitamin D) – May 2019 09 May, 2019
Vitamin or Mineral Supplements Don’t Prevent Dementia (only one Vitamin D trial, it used 400 IU) – Feb 2019 04 Feb, 2019
Treating herpes reduced incidence of senile dementia by 10 X (HSV1 reduces VDR by 8X) – 2018 17 Jan, 2019
Why dementia gets more severe in the winter – Jan 2019 14 Jan, 2019
Vitamin D and neurological diseases such as stroke, Vascular Dementia, PD, MS - July 2018 07 Dec, 2018
Osteoporosis in men increased their risk of Dementia by 1.3 (60,000 Germans) – July 2018 21 Aug, 2018
Dementia – clinical trial using 4,000 IU of Vitamin D– 2023 02 Aug, 2018
Dementia risk increased 2.4 X following TBI, even if had not lost consciousness – May 2018 12 May, 2018
Dementia less likely with increased levels of Magnesium etc. 18 Apr, 2018
5 Traumatic brain injuries resulted in 2.8 X increased risk of dementia – April 2018 11 Apr, 2018
Off Topic: Dementia risk reduced 90 percent if woman had been highly fit 40 years before 18 Mar, 2018
Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018 16 Feb, 2018
Should you have a dementia advanced directive - Jan 2018 19 Jan, 2018
Dementia risk reduced 29 percent by just 10 hours of computer brain plasticity training – RCT Dec 2017 08 Dec, 2017
Vitamin D and Multiple Sclerosis, Alzheimer's, Parkinson's ,Dementia, and ALS - review Nov 2017 23 Nov, 2017
Heart Attack increased risk of vascular dementia by 1.35 X (both associated with low vitamin D) Oct 2017 15 Nov, 2017
Dementia risk factor is increased by 1.5 if low vitamin D – meta-analysis Jan 2017 15 Jan, 2017
Dementia 19X more likely if low vitamin D – Jan 2012 27 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (nope) - Oct 2015 04 Oct, 2016
The "Surprising Link" Between Vitamin D Deficiency and Dementia (not a surprise) - Oct 2015 04 Oct, 2016
Dementia risk significantly increased if have 4 chronic diseases – all associated with low vitamin D – Sept 2015 11 Dec, 2015
Vascular dementia (after strokes) 32X more likely in Hypertensives with low vitamin D – Oct 2015 01 Nov, 2015
Dementia surprisingly associated with low vitamin D (should not a surprise) – Aug 2014 03 Oct, 2015
Dementia 13X more likely in elderly with low vitamin D – May 2014 04 Sep, 2015
Dementia risk increases with latitude (less vitamin D) - Feb 2015 20 Feb, 2015
Chance of Dementia increased 3 percent for every 1 ng less of vitamin D – Feb 2015 04 Feb, 2015
The Single Vitamin That's a Double Whammy Against Both Depression and Dementia (Mercola) – Aug 2014 21 Aug, 2014
More depression associated with more dementia in seniors (vitamin D not mentioned) – July 2014 31 Jul, 2014
Age-adjusted dementia may be declining – NEJM Dec 2013 01 Jan, 2014
Dementia risk increases 60 percent if have low vitamin D – Nov 2012 16 Dec, 2013
Dementia associated with low vitamin D in two thirds of studies – systematic review May 2013 01 Aug, 2013
Vitamin D might might reduce dementia – Mar 2011 23 Jun, 2012

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