Table of contents
Nutrition, Volume 29, Issue 6 , Pages 828-832, June 2013
Yan Zhao, B.Sc., Yan Sun, B.Sc., Hong-Fang Ji, Ph.D. jhf at sdut.edu.cn, Liang Shen, Ph.D.email address
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, P. R. China
Received 6 July 2012; accepted 25 November 2012. published online 15 February 2013.
Objective: Recent accumulating evidence shows that vitamin D deficiency is prevalent in individuals with AD and PD.
The purpose of the present study is to perform a meta-analysis on the 25-hydroxyvitamin D (25(OH)D) status in this population of patients.
Methods: We searched all articles in English published up to March 2012 concerning the 25(OH)D level in AD and PD patients.
- For AD, six studies covering 319 patients and 573 controls were included in the meta-analysis.
- For PD, five studies discussing 434 patients and 3451 controls were included.
Results: It was found that AD patients had lower levels of 25(OH)D than healthy controls (summary standardized mean difference [SMD], -1.39; 95% confidence interval [CI], -2.79 to 0.01).
Similar results were found for PD patients versus healthy controls (summary SMD, -1.33; 95% CI, -2.44 to -0.21).
Conclusion: The results indicate that despite the similar mean age between patients and healthy controls in each identified study, both AD and PD patients have lower levels of 25(OH)D than controls.
- Cummings JL. Alzheimer's disease. N Engl J Med. 2004;351:56–67
- Samii A, Nutt JG, Ransom BR. Parkinson's disease. Lancet. 2004;363:1783–1793, Full-Text PDF (149 KB)
- Plassman BL, Langa KM, Fisher GG, Heeringa SG, Weir DR, Ofstedal MB, et al. Prevalence of dementia in the United States: the aging, demographics, and memory study. Neuroepidemiology. 2007;29:125–132
- Davie CA. A review of Parkinson's disease. Br Med Bull. 2008;86:109–127
- Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. JAMA. 2006;296:2832–2838
- Knekt P, Laaksonen M, Mattila C, Härkänen T, Marniemi J, Heliövaara M, et al. Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 2008;19:666–671
- Pogge E. Vitamin D and Alzheimer’s disease: Is there a link?. Consult Pharm. 2010;25:440–450
- Slinin Y, Paudel ML, Taylor BC, Fink HA, Ishani A, Canales MT, et al. 25-Hydroxyvitamin D levels and cognitive performance and decline in elderly men. Neurology. 2010;74:33–41
- Newmark HL, Newmark J. Vitamin D and Parkinson’s disease-a hypothesis. Mov Disord. 2007;22:461–468
- Evatt ML, DeLong MR, Kumari M, Auinger P, McDermott MP, Tangpricha V, et al. High prevalence of hypovitaminosis D status in patients with early Parkinson disease. Arch Neurol. 2011;68:314–319
- Evatt ML. Beyond vitamin status: Is there a role for vitamin D in Parkinson disease?. Arch Neurol. 2010;67:795–797
- Ferrier IN, Leake A, Taylor GA, McKeith IG, Fairbairn AF, Robinson CJ, et al. Reduced gastrointestinal absorption of calcium in dementia. Age Ageing. 1990;19:368–375
- Sato Y, Asoh T, Oizumi K. High prevalence of vitamin D deficiency and reduced bone mass in elderly women with Alzheimer’s disease. Bone. 1998;23:555–557, Full-Text PDF (81 KB)
- Sato Y, Kanoko T, Satoh K, Iwamoto J. Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer’s disease. Bone. 2005; 36:61–68, Full-Text PDF (205 KB)
- Evatt ML, DeLong MR, Khazai N, Rosen A, Triche S, Tangpricha V. Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease. Arch Neurol. 2008;65:1348–1352
- Luckhaus C, Mahabadi B, Grass-Kapanke B, Jänner M, Willenberg H, Jäger M, et al. Blood biomarkers of osteoporosis in mild cognitive impairment and Alzheimer’s disease. J Neural Transm. 2009;116:905–911
- Buell JS, Dawson-Hughes B, Scott TM, Weiner DE, Dallal GE, Qui WQ, et al. 25-hydroxyvitamin D, dementia, and cerebrovascular pathology in elders receiving home services. Neurology. 2010;74:18–26
- Sato Y, Honda Y, Kaji M, Asoh T, Hosokawa K, Kondo I, et al. Amelioration of osteoporosis by menatetrenone in elderly female Parkinson’s disease patients with vitamin D deficiency. Bone. 2002; 31:114–118, Full-Text PDF (73 KB)
- Sato Y, Honda Y, Iwamoto J, Kanoko T, Satoh K. Abnormal bone and calcium metabolism in immobilized Parkinson’s disease patients. Mov Disord. 2005;20:1598–1603
- Abou-Raya S, Helmii M, Abou-Raya A. Bone and mineral metabolism in older adults with Parkinson’s disease. Age Ageing. 2009;38:675–680
- Knekt P, Kilkkinen A, Rissanen H, Marniemi J, Sääksjärvi K, Heliövaara M. Serum vitamin D and the risk of Parkinson disease. Arch Neurol. 2010;67:808–811
- Egan KM, Signorello LB, Munro HM, Hargreaves MK, Hollis BW, Blot WJ. Vitamin D insufficiency among African-Americans in the southeastern United States: Implications for cancer disparities (United States). Cancer Cause Control. 2008;19:527–535
- Lips P. Worldwide status of vitamin D nutrition. J Steroid Biochem Mol Biol. 2010;121:297–300
- Ovesen L, Andersen R, Jakobsen J. Geographical differences in vitamin D status, with particular reference to European countries. Proc Nutr Soc. 2003;62:813–821
- Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol. 2011;91:115–124
- Ogunkolade BW, Boucher BJ, Prahl JM, Bustin SA, Burrin JM, Noonan K, et al. Vitamin D receptor (VDR) mRNA and VDR protein levels in relation to vitamin D status, insulin secretory capacity, and VDR Genotype in Bangladeshi Asians. Diabetes. 2002;51:2294–2300
- Michos ED, Reis JP, Post WS, Lutsey PL, Gottesman RF, Mosley TH, et al. 25-Hydroxyvitamin D deficiency is associated with fatal stroke among whites but not blacks: The NHANES-III linked mortality files. Nutrition. 2012;28:367–371, Full-Text PDF (143 KB)
- Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: Global perspective. Ann Epidemiol. 2009;19:468–483, Full-Text PDF (1288 KB)
- Nakajima S, Iijima H, Egawa S, Shinzaki S, Kondo J, Inoue T, et al. Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition. 2011; 27:1023–1028, Full-Text PDF (554 KB)
- Borges MC, Martini LA, Rogero MM. Current perspectives on vitamin D, immune system, and chronic diseases. Nutrition. 2011;27:399–404, Full-Text PDF (288 KB)
- McKenna MJ, Freaney R. Secondary hyperparathyroidism in the elderly: Means to defining hypovitaminosis D. Osteoporos Int. 1998;8(suppl 2):S3–S6
- Thacher TD, Clarke BL. Vitamin D insufficiency. Mayo Clin Proc. 2011;86:50–60, Full-Text PDF (247 KB)
- Grant WB. Does vitamin D reduce the risk of dementia?. J Alzheimers Dis. 2009;17:151–159
- Høyer-Hansen M, Jäättelä M. Autophagy: An emerging target for cancer therapy. Autophagy. 2008;4:574–580
- Høyer-Hansen M, Nordbrandt SP, Jäättelä M. Autophagy as a basis for the health-promoting effects of vitamin D. Trends Mol Med. 2010;16:295–302
- von Essen MR, Kongsbak M, Schjerling P, Olgaard K, Odum N, Geisler C. Vitamin D controls T cell antigen receptor signaling and activation of human T cells. Nat Immunol. 2010;11:344–349
- Fisher Y, Nemirovsky A, Baron R, Monsonego A. T cells specifically targeted to amyloid plaques enhance plaque clearance in a mouse model of Alzheimer's disease. PLoS One. 2010;5:e10830
- Eyles D, Brown J, Mackay-Sim A, McGrath J, Feron F. Vitamin D3 and brain development. Neuroscience. 2003;118:641–653
- Garcion E, Wion-Barbot N, Montero-Menei CN, Berger F, Wion D. New clues about vitamin D functions in the nervous system. Trends Endocrinol Metab. 2002;13:100–105
- Kalueff AV, Lou YR, Laaksi I, Tuohimaa P. Increased anxiety in mice lacking vitamin D receptor gene. Neuroreport. 2004;15:1271–1274
- Gezen-Ak D, Dursun E, Ertan T, Hanağasi H, Gürvit H, Emre M, et al. Association between vitamin D receptor gene polymorphism and Alzheimer’s disease. Tohoku J Exp Med. 2007;212:275–282
- Lehmann DJ, Refsum H, Warden DR, Medway C, Wilcock GK, Smith AD. The vitamin D receptor gene is associated with Alzheimer's disease. Neurosci Lett. 2011;504:79–82
- Cauley JA, Lacroix AZ, Wu L, Horwitz M, Danielson ME, Bauer DC, et al. Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med. 2008;149:242–250
- Melton LJ, Beard CM, Kokmen E, Atkinson EJ, O’Fallon WM. Fracture risk in patients with Alzheimer’s disease. J Am Geriatr Soc. 1994;42:614–619
- Schneider JL, Fink HA, Ewing SK, Ensrud KE, Cummings SR, et al. The association of Parkinson's disease with bone mineral density and fracture in older women. Osteoporos Int. 2008;19:1093–1097
- Alzheimers-Cognition - Overview
- Overview Parkinson's and Vitamin D
- CLICK HERE for 157 papers on Parkinson's and vitamin D @ PubMed as of May 2013
- All items tagged with Parkinson
Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013
7649 visitors, last modified 22 May, 2013,