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Alzheimer’s and Parkinson’s diseases associated with low vitamin D – meta-analysis June 2013

Vitamin D levels in Alzheimer’s and Parkinson’s diseases: A meta-analysis

Nutrition, Volume 29, Issue 6 , Pages 828-832, June 2013
Yan Zhao, B.Sc., Yan Sun, B.Sc., Hong-Fang Ji, Ph.D. jhf at sdut.edu.cn, Liang Shen, Ph.D.email address
Shandong Provincial Research Center for Bioinformatic Engineering and Technique, Shandong University of Technology, Zibo, P. R. China
Received 6 July 2012; accepted 25 November 2012. published online 15 February 2013.

Objective: Recent accumulating evidence shows that vitamin D deficiency is prevalent in individuals with AD and PD.
The purpose of the present study is to perform a meta-analysis on the 25-hydroxyvitamin D (25(OH)D) status in this population of patients.

Methods: We searched all articles in English published up to March 2012 concerning the 25(OH)D level in AD and PD patients.

  • For AD, six studies covering 319 patients and 573 controls were included in the meta-analysis.
  • For PD, five studies discussing 434 patients and 3451 controls were included.

Results: It was found that AD patients had lower levels of 25(OH)D than healthy controls (summary standardized mean difference [SMD], -1.39; 95% confidence interval [CI], -2.79 to 0.01).
Similar results were found for PD patients versus healthy controls (summary SMD, -1.33; 95% CI, -2.44 to -0.21).

Conclusion: The results indicate that despite the similar mean age between patients and healthy controls in each identified study, both AD and PD patients have lower levels of 25(OH)D than controls.


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Definition of SMD at Cochrane

See also VitaminDWiki