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Poor cognition 26 percent more likely if low Vitamin D (29 studies) – meta-analysis July 2017

A Systematic Review and Meta-Analysis of The Effect of Low Vitamin D on Cognition

American Geriatric Society, First published: 31 July 2017. DOI: 10.1111/jgs.15012
Alicia M. Goodwill PhD, Cassandra Szoeke PhD

Cognition at VitaminDWiki

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

222 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search VitaminDWiki for dementia anywhere in text 960 items Nov 2017
Overview Schizophrenia and Vitamin D
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392

Items of Cognition and Intervention (give Vitamin D and see what happens)

Items of Cognition and Meta-analysis


Background/Objective
With an aging population and no cure for dementia on the horizon, risk factor modification prior to disease onset is an urgent health priority. Therefore, this review examined the effect of low vitamin D status or vitamin D supplementation on cognition in midlife and older adults without a diagnosis of dementia.

Design: Systematic review and random effect meta-analysis.

Setting
Observational (cross-sectional and longitudinal cohort) studies comparing low and high vitamin D status and interventions comparing vitamin D supplementation with a control group were included in the review and meta-analysis.

Participants
Studies including adults and older adults without a dementia diagnosis were included.

Measurements
Medline (PubMed), AMED, Psych INFO, and Cochrane Central databases were searched for articles until August 2016. The Newcastle-Ottawa Scale and Physiotherapy Evidence Database assessed methodological quality of all studies.

Results
Twenty-six observational and three intervention studies (n = 19–9,556) were included in the meta-analysis. Low vitamin D was associated with worse cognitive performance (OR = 1.24, CI = 1.14–1.35) and cognitive decline (OR = 1.26, CI = 1.09–1.23); with cross-sectional yielding a stronger effect compared to longitudinal studies. Vitamin D supplementation showed no significant benefit on cognition compared with control (SMD = 0.21, CI = −0.05 to 0.46).

Conclusion
Observational evidence demonstrates low vitamin D is related to poorer cognition; however, interventional studies are yet to show a clear benefit from vitamin D supplementation. From the evidence to date, there is likely a therapeutic age window relevant to the development of disease and therefore vitamin D therapy. Longitudinal lifespan studies are necessary to depict the optimal timing and duration in which repletion of vitamin D may protect against cognitive decline and dementia in aging, to better inform trials and practice towards a successful therapy.

Created by admin. Last Modification: Monday July 31, 2017 09:39:24 UTC by admin. (Version 2)
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