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Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018

Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response.

Nutr Neurosci. 2018 Feb 15:1-10. doi: 10.1080/1028415X.2018.1436639. [Epub ahead of print]
Jayedi A1, Rashidy-Pour A2, Shab-Bidar S3.

  • 1 Food (salt) Safety Research Center , Semnan University of Medical Sciences , Semnan , Iran.
  • 2 Laboratory of Learning and Memory, Research Center and Department of Physiology , School of Medicine, Semnan University of Medical Sciences , Semnan , Iran.
  • 3 Department of Community Nutrition , School of Nutritional Science and Dietetics, Tehran University of Medical Sciences , Tehran , Iran.

Dementia Risk

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Alzheimer's Risk

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VitaminDWiki

Cognitive category starts with the following

Very brief summary of Cognitive decline
Treatment : Vitamin D intervention slows or stops progression
Prevention : Many observational studies - perhaps Vitamin D prevents
Omega-3 both prevents and treats cognition
Wonder the benefits if both Vitamin D AND Omega-3 were to be used

254 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search VitaminDWiki for dementia anywhere in text 1190 items Jan 2019
Overview Schizophrenia and Vitamin D
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017

37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
Includes discussion by Dr. Cannell and Dr. David Llewellyn

Types of evidence that Vitamin D helps brain problems - 2014
https://vitamindwiki.com/tiki-index.php?page_id=8392

Alzheimers-Cognition - Overview has the following summary

Items of Cognition and Intervention (give Vitamin D and see what happens)

Items of Cognition and Meta-analysis

Items in BOTH the categories Cognition and Omega-3

 Download the PDF from Sci-Hub via VitaminDWiki

OBJECTIVE: We aimed to test the dose-response association of serum 25(OH)D and risk of dementia and Alzheimer's disease (AD).

METHODS:
We performed a systematic search of PubMed and Scopus from database inception up to September 2017. Longitudinal cohort studies reporting risk estimates of incident dementia or AD in the general population, and for three or more quantitative categories of serum 25(OH)D were included. Pooled hazard ratios (HRs) were calculated using fixed-effects/random-effects models.

RESULTS:
Seven prospective cohort studies and one retrospective cohort study (total n = 28,354) involving 1953 cases of dementia and 1607 cases of AD were included. The pooled HRs of dementia and AD were 1.09 (95%CI: 0.95, 1.24) and 1.19 (95%CI: 0.96, 1.41) for vitamin D insufficiency (10-20 ng/ml), and 1.33 (95%CI: 1.08, 1.58) and 1.31 (95%CI: 0.98, 1.65) for deficiency (<10 ng/ml), respectively. The lower risk of dementia was observed at serum 25(OH)D of ∼25 ng/ml, whereas the risk of AD decreased continuously along with the increase of serum 25(OH)D up to ∼35 ng/ml.

CONCLUSION: Higher levels of serum 25(OH)D was associated with a lower risk of dementia and AD, but we have no conclusive evidence regarding serum 25(OH)D levels of >35 ng/ml.

PMID: 29447107 DOI: 10.1080/1028415X.2018.1436639

Created by admin. Last Modification: Friday February 16, 2018 16:12:06 GMT-0000 by admin. (Version 3)

Attached files

ID Name Comment Uploaded Size Downloads
9359 Alz dose.jpg admin 16 Feb, 2018 16:02 13.24 Kb 192
9358 Dem dose minus 1.jpg admin 16 Feb, 2018 16:01 13.99 Kb 185
9357 Alzh Meta.pdf PDF 2018 admin 16 Feb, 2018 15:56 1.02 Mb 205
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