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Risk of Dementia and Alzheimer's reduced by higher levels of Vitamin D – meta-analysis Feb 2018

Vitamin D status and risk of dementia and Alzheimer's disease: A meta-analysis of dose-response.

Nutr Neurosci. 2018 Feb 15:1-10. doi: 10.1080/1028415X.2018.1436639. [Epub ahead of print]
Jayedi A1, Rashidy-Pour A2, Shab-Bidar S3.

  • 1 Food (salt) Safety Research Center , Semnan University of Medical Sciences , Semnan , Iran.
  • 2 Laboratory of Learning and Memory, Research Center and Department of Physiology , School of Medicine, Semnan University of Medical Sciences , Semnan , Iran.
  • 3 Department of Community Nutrition , School of Nutritional Science and Dietetics, Tehran University of Medical Sciences , Tehran , Iran.

Dementia Risk


Alzheimer's Risk



Cognitive category starts with the following

198 items in Cognition category

see also Alzheimers-Cognition - Overview
Overview Parkinsons and Vitamin D
Search VitaminDWiki for dementia anywhere in text 960 items Nov 2017
Overview Schizophrenia and Vitamin D
Search VitaminDWiki for "WHITE MATTER" 53 items as of Jan 2017
Types of evidence that Vitamin D helps brain problems - 2014

20 Most-visited pages in Cognition category in VitaminDWiki

Id Page Hits Last modification Creator Categories
2985 Overview Schizophrenia and Vitamin D 156121
22 Dec, 2017 14:34
admin Overviews
Top news
2072 Concussions (traumatic brain injury) getting big press coverage, vitamin D might be both a cause and a solution 131451
18 Oct, 2017 12:34
admin Sports and Vitamin D
1309 Mental Illness and Vitamin D 122225
23 Feb, 2014 12:45
admin Cognitive
584 Alzheimers-Cognition - Overview 58100
19 Mar, 2018 09:22
admin Seniors
3401 Cognitive 23718
23 Nov, 2017 19:51
ricks99 Cognitive
4180 Vitamin D is important for the central nervous system and cognition – May 2013 20936
06 Jun, 2013 22:27
admin Multiple Sclerosis
4115 Traumatic brain injury treated by Vitamin D Progesterone Omega-3 and glutamine – May 2013 19405
10 Oct, 2017 14:37
admin Sports and Vitamin D
Vitamin D and Omega-3
5021 DDT 3.8 X more prevalent with Alzheimer disease (no mention that DDT decreases vitamin D) – Jan 2014 18569
09 Oct, 2017 13:39
admin Interactions with Vitamin D
6247 ALL of the top 10 health problems of women are associated with low vitamin D 18198
22 Dec, 2016 01:54
admin Health
Top news
3673 Magnesium may be an important way to treat brain trauma 17611
07 Oct, 2017 16:50
admin Vitamin D and Magnesium
Trauma and surgery
3265 Alzheimer's Disease more likely with low vitamin D – meta-analysis Oct 2012 14024
13 Dec, 2015 23:20
admin Meta-analysis of Vitamin D
Top news
3052 Cognitive Impairment 2.4X more likely if low vitamin D – meta-analysis July 2012 13930
21 Oct, 2016 09:53
admin Meta-analysis of Vitamin D
Top news
3640 Vitamin D aided progesterone in reducing traumatic brain injury – RCT Dec 2012 10807
10 Oct, 2017 14:39
admin Trauma and surgery
5228 Schizophrenia veterans with low vitamin D more likely to smoke and have OCD, Parkinson's – April 2014 10308
01 Jul, 2015 13:39
admin Cognitive
1132 Schizophrenia and vitamin D have latitude-related genes – Nov 2010 9244
10 Dec, 2014 15:44
admin Vitamin D Far from equator
5082 Children with mental disorders have somewhat less vitamin D levels (graph) Jan 2014 8843
23 Feb, 2014 12:45
admin Depression
4028 Fewest Google searches for Mental Health when there is lots of vitamin D from the sun – May 2013 8678
29 Apr, 2013 20:21
admin Depression
Top news
5240 Vitamin D and neurocognitive function – April 2014 8404
08 Apr, 2014 11:03
admin Cardiovascular
2604 Alzheimer’s 4X less likely with high level of vitamin D – 2 studies April 2012 8113
16 Apr, 2016 14:38
admin Cognitive
4320 Vitamin D and MS, ALS, Autism, Alzheimer’s and other nervous system diseases – review Aug 2013 8074
27 Dec, 2013 03:32
admin Multiple Sclerosis

Items in BOTH the categories Cognition and Cardiovascular

Items in BOTH the categories Cognition and Genetics

Items in BOTH the categories Cognition and Vitamin D Receptor Gene

Items in BOTH the categories Cognition and Omega-3

Items of Cognition and Intervention (give Vitamin D and see what happens)

Items of Cognition and Meta-analysis

Alzheimers-Cognition - Overview has the following summary

Vitamin D Receptor category has the following

Genetics category listing contains the following

The first chart on this page untill Oct 2017 had been

The following chart triggered the creation of the chart at the top of this page


Note the assumption, which may be correct, that the immune system only responds to tissue Vitamin D, rather than from blood vitamin D

Immune modulation by Vitamin D, food allergy, chart of genes – July 2015 has the following chart
Genes and vitamin D  page 6748
All articles in both Pregnancy and Genetics:

Here are all 209 articles

Note: a software bug includes items from the subcategories of Vit D Receptor and Vit D Binding protein - sometimes 3 entries total

See also Vitamin D Binding Protein category listing has 83 items

In addition to inherited poor VDR genes, Herpes downregulates VDR by 8X for a short time

Note: Many people have Herpes but are not aware of it. (example: 48% of black women)

See also web

  • Natural Ways to Increase Calcitriol and Activate The Vitamin D Receptor Gene Selfhacked Jan 2016 - has lots of linked references
    Includes Exercise, RXR ( and retinol) is needed to produce proteins with the VDR, SIRT1 -potentiates VDR, PGC-1a, Dopamine
    Bile, Omega-3: Omega-6:Curcumin, Resveratrol, Forskolin , Gamma Tocotrienol, Estradiol,
    What Inhibits The Vitamin D Receptor (VDR) or Calcitriol
    Caffeine , Cortisol/Glucocorticoids, Prolactin, Thyroid hormones,Corticosteroids decrease calcitriol,Phosphatonin, Ketoconazole, Heparin and Thiazides decrease
    Pathogens That Inhibit The Vitamin D Receptor include
    P. aeruginosa, H. pylori, Lyme/Borrelia – Live Borrelia reduces VDR by 50 times (in monocytes).
    Tuberculosis – Reduces VDR 3.3-fold.“Gliding” biofilm bacteria, Shigella, Mycobacterium leprase
    Epstein-Barr virus (EBV) – Decreases VDR by a factor of about five, HIV – binds to the VDR (R) and inhibits conversion to active D
    Aspergillus fumigatus – In cystic fibrosis patients,
    Cytomegalovirus – CMV decreases VDR 2.2 fold, Hepatitis C virus – Inhibits CYP24A1|Changes in vitamin D endocrinology during aging in adults] June 2017
  • Changes in vitamin D endocrinology during aging in adults June 2017
  • "Aging leads to a decrease in vitamin D receptor number in several organs."
    Interesting, details are behind a paywall
  • Bioinformatic approaches to interrogating vitamin D receptor signaling - Sept 2017
    No such attachment on this page
  • Calcitriol receptor = VDR Wikipedia
    "Glucocorticoids are known to decrease expression of VDR,"
    "Mutations in this gene are associated with type II vitamin D-resistant rickets"
    "The vitamin D receptor plays an important role in regulating the hair cycle."


Light activates VDR at conception,etc. - April 2017
VDR gene methylation as a molecular adaption to light exposure: Historic, recent and genetic influences.
Am J Hum Biol. 2017 Apr 22. doi: 10.1002/ajhb.23010. [Epub ahead of print]
Beckett EL1,2,3, Jones P1, Veysey M2,4, Duesing K3, Martin C1, Furst J5, Yates Z6, Jablonski NG7, Chaplin G7, Lucock M1.
Eighty subjects were examined for VDR gene-CpG island methylation density. VDR gene variants were also examined by PCR-RFLP.
Duration of early-life light exposure and strength of recent irradiance, along with latitudinal genetic factors, influence degree of VDR gene methylation consistent with this epigenetic phenomenon being a molecular adaptation to variation in ambient light exposure. Findings contribute to our understanding of human biology.
Short URL = is.gd/VitDReceptor

Alzheimer’s disease – vitamin D looks promising – Annweiler Jan 2014 has a VDR chart

On the WEB

  • Alzheimer's summary at Vitamin D Council updated Dec 2015
  • 37 minute podcast Vitamin D and the brain Vitamin D Council Sept 2014
    discussion by Dr. Cannell and Dr. David Llewellyn
  • Cognitive Imparement Vitamin D Council update Sept 2017
  • Is Alzheimer’s Type 3 Diabetes? New York Times Sept 2012]
    Idea has been around since 2005. Brain cells become insulin resistant - first noticed by Dr. Alzheimer
    people with diabetes are at least twice as likely to get Alzheimer’s
  • PubMed Alzheimer's AND Insulin in title 299 items as of Dec 2017
    "Insulin Resistance and Alzheimer's Disease: Bioenergetic Linkages." Oct 2017 free PDF online
    "Insulin signaling: An opportunistic target to minify the risk of Alzheimer's disease." Sept 2017
    "Insulin resistance in Alzheimer's disease." May 2017
  • Vitamin D and neurology WikiPedia
    has sections on Dementia: Alzheimer's disease, Parkinson's disease, Multiple sclerosis, Epilepsy and seizures, Schizophrenia
  • Alzheimer's nutrient status - July 2014 includiing vitamin D - attached at the bottom of this page
  • Vitamin D Deficiency and Alzheimer Disease: Common Links July 2015, Publisher wants $40 for the PDF
    "Based on this accumulation of studies, we propose that VitD screening should be performed at least in those individuals at risk for VitD deficiency and AD"
  • Is It Alzheimer’s, or A.D.H.D.? New York Times Sept 2015
    3 % of Dutch over 60 have A.D.H. D. It overlaps with age-related cognitive decline
  • Probiotics improve cognition in Alzheimer's patients RCT Nov 2016
    Nothing about Vitamin D. 12 weeks of probiotics for Alzheimer's patients increased mental test score from 8.7 to 10.6 (max score = 30)
  • Should I Take The Gene Test For Alzheimer's? GreenMed Info. April 2017
    Yes:should have a gene test, especially if Alz runs in the family
    If you have two copies of APOE4 gene you cam be at 12X risk of getting Alzheimer's
    Personal note: I (Henry Lahore) have just one copu of the gene, so I have a 3X risk - the only gene risk from my 23andMe report
        Supplementing vitamin D, etc virtually eliminates my increased risk*6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
  • Age-adjusted = increase is NOT due to having a larger elderly population

_Dementia death rate - age standardized @is.gd/increasedisease

  • 6X increase in Age-Adjusted Death from Dementia (Finland) in 30 years
    Age-adjusted = increase is NOT due to having a larger elderly population

Dementia death rate - age standardized @is.gd/increasedisease

  • From Fight Aging On Increasing Your Chances of Avoiding Alzheimer's July 2011
    In many ways, Alzheimer's Disease looks a lot like type 2 diabetes - it can be argued that there are some biochemical similarities in the underlying mechanisms, Alzheimer's appears to be a lifestyle disease to some degree, and the two conditions have many of the same risk factors, such as obesity and being sedentary. So: "Over half of all Alzheimer's disease cases could potentially be prevented through lifestyle changes and treatment or prevention of chronic medical conditions. ...
    Analyzing data from studies around the world involving hundreds of thousands of participants, [researchers] concluded that worldwide, the biggest modifiable risk factors for Alzheimer's disease are, in descending order of magnitude, low education, smoking, physical inactivity, depression, mid-life hypertension, diabetes and mid-life obesity. ...

In the United States, [researchers] found that the biggest modifiable risk factors are

  • physical inactivity,
  • depression,
  • smoking,
  • mid-life hypertension,
  • mid-life obesity,
  • low education and
  • diabetes. ...

Note: EVERY SINGLE ONE of the above associations with Alzheimer's Disease is also associated with low vitamin D:

  • physical inactivity - not get out in the sun
  • depression category - a common result of low vitamin D:
  • Smoking - well known to consume vitamin D
  • mid-life hypertension a result of low vitamin D:
  • mid-life obesity - which results from low vitamin D, and Obesity makes vitamin D levels even lower
  • Low education - take far fewer nutritional supplements - due to cost, knowledge, belief
    • Note: low education is also associated with dark skinned people, who get less vitamin D from the sun
  • diabetes - a result of low vitamin D:

Clinical Trials underway for Cognition and Vitamin D INTERVENTION

Vitamin D, Cognition and Alzheimer's Disease: The Therapeutic Benefit is in the D-Tails - May 2016

J Alzheimers Dis. 2016 May 11;53(2):419-44. doi: 10.3233/JAD-150943.
Landel V1, Annweiler C2,3, Millet P1,4, Morello M1,5,6, Féron F1.
Fig. 2. Proposed mechanisms of vitamin D-mediated multitargeted effects in AD. Vitamin D imbalance is proposed to alter mechanisms implicated in aging and AD pathogenesis. Suggested protective effects of vitamin D supplementation concern regulation of vascular processes and oxidative stress, calcium homeostasis, neurotransmission, modulation of immune and inflammatory processes, and direct impact on amyloidogenesis, ultimately improving cognitive functions.

Age-adjusted Death rates: Alzheimer's has been increasing the fastest


Alzheimer's in more than half of hospital patients over age 65


Work changes due to Alzheimer's or Dimentia care-giving


What if we could delay onset of Alzheimer's by 5 years - Alzheimer's Association - 2015

No such attachment on this page
Looks like about half of the people would not have Alzheimer's costs (die sooner?)

Cognition other than Vitamin D monotherapy

Magnesium and Mental Health  see  is.gd/VDMag

Items in BOTH Cognition and Omega-3 categories

APOE4 gene greatly increases risk of AD, but had been a benefit during childhood

The APOe4 gene protected our ancestors and helped them get through the child bearing years by attacking parasites and micro-organisms with oxidative stress. It is only in modern times that people live long enough for the same oxidative stress to work against us in old age.
A book, Survival of the Sickest,(2008) points out roughly the same concept in a number of other diseases which long ago helped our ancestors get through plagues, ice ages, parasites, famine, etc. It's a fascinating concept and it makes sense. By Rich H, Jan 2017
No such attachment on this page

Small amount of Lithium slowed dementia in Alzheimer's

  • Life Extension Magazine, Dec 2016, Nothing about Vitamin D.
    Boron may provide similar benefit, at far lower cost
    No such attachment on this page
  • Lithium as Nutrient - 2015 Alz and many other health problems
        No such attachment on this page
  • Association Between Lithium Use and Risk of Alzheimer's Disease PubMed Dec 2016
    looked ay 200,000 elderly. 1.8X less likely to get Alzheimer's if had been taking Lithium
  • Lithium to the Rescue. PubMed Feb 2016
        No such attachment on this page

Rate of a rare form of early-onset Alzheimer's associated with Aluminium - 2017

Bill Gates put $50 million into Alzheimer's Research - Fall 2017 (no mention about Vitamin D)

  • Why I’m Digging Deep Into Alzheimer’s Bill Gates Blog
    "A person with Alzheimer’s or another form of dementia spends five times more every year out-of-pocket on healthcare than a senior without a neurodegenerative condition"
    For example, we don’t fully understand why you are more likely to get Alzheimer’s if you’re African American or Latino than if you’re white"
    VitaminDWiki suspects that the increased risk is due to lower levels of vitamin D in those with dark skins
  • Bill Gates' newest mission: Curing Alzheimer's CNN
    "Since 2002, there have been more than 400 Alzheimer drug trials run and yet no treatments"

Risk of Dementia reduced 50% by just using Brain Plasticity Software for just 13 hours - Nov 2017

Posit Science - 10 year experiment, full free text online
Speed of processing training results in lower risk of dementia


Items of Cognition and Intervention (give Vitamin D and see what happens)

Items of Cognition and Meta-analysis

Items in BOTH the categories Cognition and Omega-3

 Download the PDF from Sci-Hub via VitaminDWiki

OBJECTIVE: We aimed to test the dose-response association of serum 25(OH)D and risk of dementia and Alzheimer's disease (AD).

We performed a systematic search of PubMed and Scopus from database inception up to September 2017. Longitudinal cohort studies reporting risk estimates of incident dementia or AD in the general population, and for three or more quantitative categories of serum 25(OH)D were included. Pooled hazard ratios (HRs) were calculated using fixed-effects/random-effects models.

Seven prospective cohort studies and one retrospective cohort study (total n = 28,354) involving 1953 cases of dementia and 1607 cases of AD were included. The pooled HRs of dementia and AD were 1.09 (95%CI: 0.95, 1.24) and 1.19 (95%CI: 0.96, 1.41) for vitamin D insufficiency (10-20 ng/ml), and 1.33 (95%CI: 1.08, 1.58) and 1.31 (95%CI: 0.98, 1.65) for deficiency (<10 ng/ml), respectively. The lower risk of dementia was observed at serum 25(OH)D of ∼25 ng/ml, whereas the risk of AD decreased continuously along with the increase of serum 25(OH)D up to ∼35 ng/ml.

CONCLUSION: Higher levels of serum 25(OH)D was associated with a lower risk of dementia and AD, but we have no conclusive evidence regarding serum 25(OH)D levels of >35 ng/ml.

PMID: 29447107 DOI: 10.1080/1028415X.2018.1436639

Created by admin. Last Modification: Friday February 16, 2018 16:12:06 UTC by admin. (Version 3)
The most recent items in category Meta-analysis of Vitamin D
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Attached files

ID Name Comment Uploaded Size Downloads
9359 Alz dose.jpg admin 16 Feb, 2018 16:02 13.24 Kb 42
9358 Dem dose minus 1.jpg admin 16 Feb, 2018 16:01 13.99 Kb 42
9357 Alzh Meta.pdf PDF 2018 admin 16 Feb, 2018 15:56 1.02 Mb 36
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